Results 191 to 200 of about 12,926,306 (256)

In vitro characterization of a bispecific anti-(PD-1/CTLA-4) single-chain diabody for cancer immunotherapy. [PDF]

Sci Rep
Ghoreishi M, Esmaeil N, Akbari V, Abbaspour M.   +3 more
europepmc   +1 more source

Complete Regression of bilateral Choroidal Metastases secondary to a Cutaneous Melanoma under Immunotherapy

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Yenny Angela, Alena Riesmeier, Ralf Gutzmer, Miltiadis Fiorentzis, Nikolaos E. Bechrakis, Carsten Framme, Ekaterina Sokolenko   +6 more
wiley   +1 more source

Antiresorptive therapy influence on peri‐implant diseases: Clinical implications and osteoimmunological perspectives

Periodontology 2000, EarlyView.
Abstract Background/Aim Antiresorptive therapy represents a cornerstone in the management of osteoporosis and cancer‐related bone disease through suppression of osteoclast‐mediated bone resorption. As implant therapy becomes more common in aging populations, clinicians increasingly encounter patients receiving these medications, thus making their ...
Emilio A. Cafferata, Frank Schwarz, Reinhard Gruber   +2 more
wiley   +1 more source

Life-threatening anaphylactic shock induced by cadonilimab (AK104), a PD-1/CTLA-4 bispecific antibody: a case report. [PDF]

Front Pharmacol
Zheng Z, Li J, Huang Q.
europepmc   +1 more source

Assessment of Clinical and Immunological Factors of Local Recurrence in Canine Soft Tissue Sarcoma

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Canine soft tissue sarcomas (STSs) are locally invasive tumours, making local recurrence a major clinical challenge. Time to recurrence (TTR) and associated immune factors remain poorly characterized. This study aimed to characterize the immune microenvironment of canine STS and identify factors associated with TTR.
Kazuki Mizuta, Helene Philibert, Arata Matsuyama   +2 more
wiley   +1 more source

Immune dysregulation from a novel CTLA-4 haploinsufficiency variant. [PDF]

J Hum Immun
Brodsky NN, Kennedy A, Glaser D, Jeffries L, Ji W, Natarajan E, Shin JJ, Sansom DM, Lucas CL, Lakhani SA.   +9 more
europepmc   +1 more source

Histiocytes: Multifaceted Regulators of Health and Disease

Veterinary Clinical Pathology, EarlyView.
ABSTRACT The mononuclear phagocyte system encompasses macrophages, dendritic cells (DCs), and monocytes. Tissue‐resident macrophages and dendritic cells arise during embryogenesis and are replenished either through self‐renewal or by monocytes during inflammation.
Erika J. Gruber
wiley   +1 more source

Immune checkpoint crosstalk: CTLA-4/CD80 engagement as a predictor of anti-PD-1/PD-L1 therapy outcome in NSCLC. [PDF]

Front Immunol
Gumuzio J, Miles J, Quimi N, Rementeria M, Cacho C, Camacho L, Geraedts EJ, van Elst K, Aguirre F, Parker PJ, Calleja V.   +10 more
europepmc   +1 more source

The role of extracellular vesicles in cell–cell crosstalk in cardiotoxicity

The Journal of Physiology, EarlyView.
Abstract figure legend Administration of a pharmacological agent can result in off‐target cardiotoxicity which can be driven by cell–cell crosstalk between healthy and dysfunctional cardiac cells. Extracellular vesicles (EVs) are lipid bilayer structures that can move biological cargo between cells, facilitating cell–cell crosstalk.
Gabriella Bachynskyj‐Bilas, Debbie J. Otto, Daniel Stratton, Katja Rietdorf, Daniel M. Johnson, Calum J. McMullen   +5 more
wiley   +1 more source