Results 61 to 70 of about 2,755 (211)

Beyond Traditional Screening: The Future of Heart Failure Detection With Biomarkers and AI

open access: yesiNew Medicine, EarlyView.
Advancing HF Screening: Integrating Technology and Risk Factors Across Eras. This diagram provides a comprehensive review of the historical developments and projected trends of heart failure (HF) screening methodologies, with the prevalent risk factors for HF depicted at the base.
Xiaofeng Fang   +9 more
wiley   +1 more source

amMSC microvesicle transfer of mRNA to CTNS(−/−) mutant fibroblasts.

open access: yes, 2013
(a) RT/PCR amplicon of CTNS (spanning exons 10 to 12) obtained from RNA extracted from amMSC microvesicles. (b) RT/PCR showing absence of CTNS mRNA in GFP-tagged CTNS(−/−) mutant fibroblasts isolated by FACS after 4 days of co-culture with untagged ...
Reyhan El-Kares (311952)   +13 more
core   +1 more source

Temporary VAT Reduction in Vietnam: Consumer Behavior Analysis

open access: yesInternational Studies of Economics, EarlyView.
ABSTRACT This study investigates the impact of temporary VAT rate changes on consumer behavior in Vietnam, particularly concerning the VAT reduction implemented during 2023–2024. The research analyzes annual survey data and household expenditure reports to assess changes in consumer spending on durable goods during the first half of 2024 (2024 H1 ...
Hang Thi Thu Trinh
wiley   +1 more source

In vitro Metabolomic Approaches to Investigating the Potential Biological Effects of Phenolic Compounds: An Update

open access: yesGenomics, Proteomics & Bioinformatics, 2017
Dietary phenolic compounds (PCs) have been receiving interest for their presumed roles in disease prevention. However, there is a lack of studies on the underlying molecular mechanisms. In this regard, in vitro metabolomic approaches are suitable for the
Úrsula Catalán   +4 more
doaj   +1 more source

First National Expanded Genomic Newborn Screening Program in Qatar; A Pilot Study, Doha‐Heidelberg Collaboration

open access: yes
American Journal of Medical Genetics Part A, EarlyView.
Reem Alsulaiman   +18 more
wiley   +1 more source

Porous Organic Polymers: From Molecular Design to Scalable Technologies

open access: yesSmall, EarlyView.
This review introduces porous organic polymers (POPs) for a wide range of applications, including energy storage, gas adsorption, catalysts, adsorbents, biomedical applications, sensors, and other exciting fields, and critically analyzes the synthesis and modification, and how structural topology influences the composites' architecture of POPs, along ...
Hossein Mashhadimoslem   +12 more
wiley   +1 more source

Characterization of the CtnsY226X/Y226X mouse model.

open access: yes, 2019
A. Schematic diagram of Ctns transcript showing the Ctns Y226X nonsense mutation in exon 8. B. Half-cystine levels in 9-month old CtnsY226X/Y226X mouse kidneys was elevated compared to wildtype. C. Ctns transcript level (RT-qPCR) in CtnsY226X/Y226X mouse
Pedro Huertas (4891903)   +9 more
core   +1 more source

Chaperone-Mediated Autophagy Upregulation Rescues Megalin Expression and Localization in Cystinotic Proximal Tubule Cells

open access: yesFrontiers in Endocrinology, 2019
Cystinosis is a lysosomal storage disorder caused by defects in CTNS, the gene that encodes the lysosomal cystine transporter cystinosin. Patients with nephropathic cystinosis are characterized by endocrine defects, defective proximal tubule cell (PTC ...
Jinzhong Zhang   +6 more
doaj   +1 more source

Lysosomal cystine export regulates mTORC1 signaling to guide kidney epithelial cell fate specialization

open access: yesNature Communications, 2023
Differentiation is critical for cell fate decisions, but the signals involved remain unclear. The kidney proximal tubule (PT) cells reabsorb disulphide-rich proteins through endocytosis, generating cystine via lysosomal proteolysis.
Marine Berquez   +11 more
doaj   +1 more source

Numerically efficient mechanical modeling of reinforced concrete membrane elements with fixed, interlocked cracks

open access: yesStructural Concrete, EarlyView.
Abstract Compression field approaches such as the Cracked Membrane Model with fixed, interlocked cracks (CMM‐F) are efficient tools for the mechanical modeling of reinforced concrete elements, providing the mechanical model σ=fε$$ \boldsymbol{\upsigma} =f\left(\boldsymbol{\upvarepsilon} \right) $$ required for finite element analyses.
Andreas Näsbom   +2 more
wiley   +1 more source

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