A flow platform for degradation-free CuAAC bioconjugation [PDF]
Nature Communications, 2018 Cu-catalyzed azide-alkyne cycloaddition (CuAAC) reaction is a common bioconjugation technique; however oxidative degradation and residual copper may limit its use.
Marine Z. C. Hatit +5 more
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Polypropylene-based graft copolymers via CuAAC click chemistry
eXPRESS Polymer Letters, 2018 Graft copolymers from commercial chlorinated polypropylene (PP-Cl) possessing either poly(ethylene glycol) (PEG) or poly(ε-caprolactone) (PCL) grafts are synthesized by copper (I)-catalyzed azide-alkyne cycloaddition ‘click’ reaction (CuAAC).
G. Acik, E. Sey, M. A. Tasdelen
doaj +7 more sources
AT-CuAAC Synthesis of Mechanically Interlocked Oligonucleotides [PDF]
Journal of the American Chemical Society, 2020 We present a simple strategy for the synthesis of main chain oligonucleotide rotaxanes with precise control over the position of the macrocycle. The novel DNA-based rotaxanes were analyzed to assess the effect of the mechanical bond on their properties.
Amanda Acevedo-Jake +7 more
semanticscholar +7 more sources
Peptide Conjugation via CuAAC ‘Click’ Chemistry [PDF]
Molecules, 2013 The copper (I)-catalyzed alkyne azide 1,3-dipolar cycloaddition (CuAAC) or ‘click’ reaction, is a highly versatile reaction that can be performed under a variety of reaction conditions including various solvents, a wide pH and temperature range, and ...
Istvan Toth +3 more
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A CuAAC–Hydrazone–CuAAC Trifunctional Scaffold for the Solid-Phase Synthesis of Trimodal Compounds: Possibilities and Limitations [PDF]
Molecules, 2015 We present a trifunctional scaffold designed for the solid-phase synthesis of trimodal compounds. This scaffold holds two alkyne arms in a free and TIPS-protected form for consecutive CuAAC (copper(I)-catalyzed azide–alkyne cycloaddition), one Fmoc ...
Benjamin Fabre +4 more
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Pathway selection between click and acyl transfer reactions driven by aminoacyl phosphates [PDF]
Nature CommunicationsCovalent transformations in biology follow defined temporal sequences that regulate processes such as acylation and phosphorylation, yet achieving comparable temporal control in synthetic systems remains challenging.
Debjyoti Bhattacharjee +6 more
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Held out wings RNA binding activity in the cytoplasm during early spermatogenesis [PDF]
Communications BiologyHeld out wings (HOW) is an RNA-binding protein essential for spermatogenesis in Drosophila melanogaster. HOW is a signal transduction and activation of RNA (STAR) protein, regulating post-transcriptional gene expression.
Michaela Agapiou +7 more
doaj +2 more sources
Atroposelective interrupted CuAAC reaction using cyclic diaryliodoniums [PDF]
Nature CommunicationsCopper-catalyzed azide–alkyne cycloaddition (CuAAC) is a pivotal strategy for joining two fragments, including bioactive moieties under mild conditions.
Yuanyuan Li +3 more
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inCu-click: DNA-enhanced ligand enables live-cell, intracellular click chemistry reaction with copper catalyst [PDF]
Nature CommunicationsLabeling cellular biomolecules via copper-catalyzed azide–alkyne cycloaddition (CuAAC) offers rapid reaction kinetics and uses small azide and alkyne probes that minimally disturb molecular function, making it ideal for tracking biomolecules.
Keqing Nian +6 more
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Beilstein Journal of Organic Chemistry, 2022 The conversion of tetrazolo[1,5-a]quinoxalines to 1,2,3-triazoloquinoxalines and triazoloimidazoquinoxalines under typical conditions of a CuAAC reaction has been investigated.
Laura Holzhauer +4 more
doaj +1 more source