Results 91 to 100 of about 9,957 (210)

Development of a Self‐Adjuvanting Influenza Peptide–Glycolipid Conjugate Inducing CD8+ T‐Cell Immunity

ChemBioChem, Volume 27, Issue 5, 13 March 2026.
The glycolipid‐peptide antigen complexes for self‐adjuvanting conjugates were successfully synthesized, and, with the HLA‐transgenic mice, the antigen‐specific CD8+ T cell expansion was exhibited. The results provide useful insights for the design and synthesis of vaccine conjugates using glycolipid antigen as an adjuvant.
Shunya Kikuchi, Hideki Ogura, Takanori Matsumaru, Satoshi Ishido, Yukari Fujimoto   +4 more
wiley   +1 more source

Antibacterial film from chlorinated polypropylene via CuAAC click chemistry

Progress in Organic Coatings, 2018
Abstract Polypropylene possessing quaternary ammonium salt (PP-QAS) is synthesized by copper (I)-catalyzed azide- alkyne cycloaddition “click” reaction (CuAAC) starting from chlorinated polypropylene (PP-Cl). The antibacterial properties of PP-QAS have been investigated on gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli ...
Gokhan Acik, Cagatay Altinkok, Hulya Olmez, Mehmet Atilla Tasdelen   +3 more
openaire   +5 more sources

Synthesis and Evaluation of the First Generation of Glycosylated Nucleoside Analogues as Potential Inhibitors of the Base J Metabolism in Kinetoplastid Parasites

Chemistry – A European Journal, Volume 32, Issue 10, 9 March 2026.
Novel analogues of the kinetoplastid‐specific DNA base J unlock a new way to target parasite epigenetic regulation. Some compounds selectively inhibit Leishmania and Trypanosoma species without harming human cells, revealing a promising route toward innovative antiparasitic therapies.
Océane Monfret, Dan Liu, Manon Louis, Sihem Rebei, Dominique Urban, Yann Bourdreux, Elisabeth Mouray, Philippe Grellier, Gilles Doisneau, Dominique Guianvarc'h   +9 more
wiley   +1 more source

Polymeric Micellar Nanocatalysts for CuAAC Click Reaction in Water

Langmuir
Polymer-supported copper catalysts have attained a prominent status and continue to be a focal point of ongoing research and development due to their adaptable properties, which make them invaluable tools for diverse catalytic reactions in aqueous solutions.
Witsanu Sombat, Panuwat Padungros, Voravee P. Hoven   +2 more
openaire   +2 more sources

Directed Functionalization of Recombinant Spider Silk Nonwoven Membranes with Antibodies Using Non‐Canonical Amino Acids

Advanced Materials, Volume 38, Issue 14, 6 March 2026.
A recombinant spider silk protein was functionalized by incorporating genetically encoded bio‐orthogonal reactive azido‐groups. The azido‐functionalized proteins were produced in a scalable biotechnological process, and particles, films, as well as nanofibers were established as anchorage for fully functional antibodies via site‐specific bio‐orthogonal
Claudia Lacombe, Charlotte Leonhardt, Martin Humenik, Birgit Wiltschi, Thomas Scheibel   +4 more
wiley   +1 more source

Membrane‐Penetrating Molecular Device Based on a Triplex Containing Acyclic L‐Threoninol Nucleic Acid Functionalized with Cholesterol

Angewandte Chemie, Volume 138, Issue 9, 23 February 2026.
A membrane‐penetrating molecular device composed of triplex containing cholesterol‐modified acyclic L‐threoninol nucleic acid (L‐aTNA) was achieved. This device is applied to a photo‐triggered signal transduction system functioning on giant unilamellar vesicles. Abstract Membrane‐penetrating molecular devices are valuable biological tools.
Kaifu Liu, Hiroyuki Asanuma, Keiji Murayama   +2 more
wiley   +2 more sources

Organic and Metallacages for Chemical Sensing: Progress in Water‐Compatible Systems

Advanced Sensor Research, Volume 5, Issue 3, March 2026.
Supramolecular cages function as three‐dimensional receptors for selective molecular recognition and sensing, and this review outlines design principles for water‐stable architectures, key analyte‐ and medium‐dependent challenges, recent water‐compatible examples (including polymer‐integrated systems), and future opportunities for cage‐based ...
Rabia Zahid, Martina Viola, Maria Vittoria Balli, Guillermo Moreno‐Alcántar, Pierre Picchetti   +4 more
wiley   +1 more source

Monoaminylation in Human Health and Disease: State of the Field, Challenges, and Emerging Directions

Advanced Science, Volume 13, Issue 16, 18 March 2026.
This review delineates monoaminylation—serotonylation, dopaminylation, and histaminylation—as key post‐translational modifications beyond receptor signaling. It details their catalytic mechanisms, roles in gene expression and protein function, and implications in health and disease, aiming to bridge mechanistic insights with therapeutic potential ...
Yiqi Zhao, Hongli Zhang, Yating Yang, Wei‐Dong Chen, Yan‐Dong Wang   +4 more
wiley   +1 more source

In-vitro cytotoxic activities of poly(2-ethyl-2-oxazoline)-based amphiphilic block copolymers prepared by CuAAC click chemistry

, 2018
. Synthesis and characterization of well-defined amphiphilic block copolymers containing poly(2-ethyl-2-oxazoline) as hydrophilic block and poly(ε-caprolactone) or poly(L-lactide) as hydrophobic block is achieved by copper-catalyzed azide-alkyne ...
Sevgi Gulyuz, Umut Ugur Ozkose, P. Koçak, D. Telci, Ozgur Yilmaz, M. Taşdelen   +5 more
semanticscholar   +1 more source

Click Chemistry and Bioorthogonal Reaction for Aggregation‐Induced Emission Bioconjugates

Aggregate, Volume 7, Issue 3, March 2026.
This review highlights the construction of AIE active bioconjugates via click chemical or bioorthogonal reactions, and their applications in biosensing, bioimaging, and image‐guided treatment. The challenges and perspectives in the area are also discussed.
Xinzhe Yang, Miaomiao Kang, Dong Wang, Ben Zhong Tang   +3 more
wiley   +1 more source