Results 11 to 20 of about 9,957 (210)
European Journal of Medicinal Chemistry Reports, 2023 Natural products play a key role in the history of human drug discovery, and especially for the anticancer agents. Copper(I)-catalyzed alkyne-azide [3+2] cycloaddition (CuAAC) reaction is perhaps the most powerful method for the efficient modification of
Zaozao Xiao +8 more
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Cationic Copper Iminophosphorane Complexes as CuAAC Catalysts: A Mechanistic Study [PDF]
Organometallics, 2020 We have combined Cu K-edge X-ray absorption spectroscopy with NMR spectroscopy (1H and 31P) to study the Cu-catalyzed azide–alkyne cycloaddition (CuAAC) reaction under operando conditions. A variety of novel, well-defined CuI iminophosphorane complexes were prepared.
Bas Venderbosch +4 more
openaire +5 more sources
Molecules, 2016 The emergence of bioorthogonal reactions has greatly broadened the scope of biomolecule labeling and detecting. Of all the bioorthogonal reactions that have been developed, the copper-catalyzed azide-alkyne cycloaddition (CuAAC) is the most widely ...
Li Li, Zhiyuan Zhang
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ACS Omega, 2023 Click chemistry is currently one of the most used tools for the generation of complex organic molecules. The advantages of using click chemistry in organic synthesis are remarkable; in many cases, the reactions occur under mild conditions and are free of
H. M. Pineda-Castañeda +2 more
semanticscholar +1 more source
CuAAC ensembled 1,2,3-triazole linked nanogels for targeted drug delivery: a review
RSC Advances, 2023 Copper(i) catalyzed alkyne azide cycloaddition (CuAAC), the quintessential example of ‘click chemistry’, provides an adaptable and adequate platform for the synthesis of nanogels for sustained drug release at targeted sites because of their better ...
Gurleen Singh +8 more
semanticscholar +1 more source
CuAAC-inspired synthesis of 1,2,3-triazole-bridged porphyrin conjugates: an overview
Beilstein Journal of Organic Chemistry, 2023 Among all the available approaches in organic synthesis, the “click chemistry” protocol is very common nowadays to covalently connect two diverse moieties in a single framework. Therefore, this review focuses on the synthesis and photophysical studies of
Dileep Kumar Singh
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Organometallics, 2022 Copper(I) [Cu2(μ-Br)2(tBuImCH2pyCH2L)]n (L = OMe, NEt2, NHtBu) compounds supported by flexible functionalized NHC-based polydentate ligands have been prepared in a one-pot procedure by reacting the corresponding imidazolium salt with an excess of copper ...
M. González-Lainez +6 more
semanticscholar +1 more source
Synthesis and CuAAC Reactions of Azidoalkylethoxysilanes: Grafting CuAAC Products onto Silica Surface [PDF]
Synthetic Communications, 2013 One-pot synthetic protocols of novel azido functionalized silane coupling agents from corresponding terminal mesylated or tosylated 1-olefins were developed. Azido groups were successfully converted to the corresponding 1,2,3-triazol ring by the copper-catalyzed azido alkyne coupling (CuAAC) reaction without alkoxysilane decomposition.
Kultyshev, Roman G. +3 more
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Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 The synthesis of four tetra-tacrine clusters where the tacrine binding units are attached to a central scaffold via linkers of variable lengths is described.
Tereza Cristina Santos Evangelista +5 more
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A Genetically Encoded Picolyl Azide for Improved Live Cell Copper Click Labeling
Frontiers in Chemistry, 2021 Bioorthogonal chemistry allows rapid and highly selective reactivity in biological environments. The copper-catalyzed azide–alkyne cycloaddition (CuAAC) is a classic bioorthogonal reaction routinely used to modify azides or alkynes that have been ...
Birthe Meineke +9 more
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