Results 21 to 30 of about 9,957 (210)
Catalysis Communications, 2023 The demand for environmental friendly methodologies had shifted the the approach of scientific community for using easy and green reaction conditions instead of using hazardous and harsh reaction conditions.
Vijay Kumar +3 more
doaj +1 more source
Angewandte Chemie, 2021 Carbon nanodots (CDs) originating from different biomass result in different activities to sensitize photo‐ATRP and photo‐CuAAC reaction protocols with visible light.
Ceren Kütahya +7 more
semanticscholar +1 more source
Site-specific bioconjugation of a murine dihydrofolate reductase enzyme by copper(I)-catalyzed azide-alkyne cycloaddition with retained activity. [PDF]
PLoS ONE, 2014 Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) is an efficient reaction linking an azido and an alkynyl group in the presence of copper catalyst. Incorporation of a non-natural amino acid (NAA) containing either an azido or an alkynyl group into a ...
Sung In Lim +4 more
doaj +1 more source
Multitarget Anticancer Agents Based on Histone Deacetylase and Protein Kinase CK2 inhibitors
Molecules, 2020 The design of multitarget drugs (MTDs) has become an innovative approach for the search of effective treatments in complex diseases such as cancer. In this work, we communicate our efforts in the design of multi-targeting histone deacetylase (HDAC) and ...
Regina Martínez +9 more
doaj +1 more source
ACS Catalysis, 2022 : Copper-catalyzed azide-alkyne cycloaddition (CuAAC) is one of the most versatile reactions in the “ click chemistry ” toolbox, and its development has made the synthesis of 1,4-triazole derivatives robust and e ffi cient.
J. Héron, David Balcells
semanticscholar +1 more source
Site-Specific Fluorogenic Protein Labelling Agent for Bioconjugation
Biomolecules, 2020 Many clinically relevant therapeutic agents are formed from the conjugation of small molecules to biomolecules through conjugating linkers. In this study, two novel conjugating linkers were prepared, comprising a central coumarin core, functionalized ...
Kelvin K. Tsao +3 more
doaj +1 more source
ACS Omega, 2022 Copper(I)-catalyzed alkyne–azide cycloaddition (CuAAC) is a resourceful and stereospecific methodology that has considerably yielded promising 1,2,3-triazole-appended “click” scaffolds with the potential for selective metal ion recognition.
Gurleen Singh +7 more
semanticscholar +1 more source
Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling.
Analytical Chemistry, 2021 Mass-spectrometry-based chemoproteomics has enabled the rapid and proteome-wide discovery of functional and potentially 'druggable' hotspots in proteins.
Jian Cao +7 more
semanticscholar +1 more source
Direct-to-Biology: Streamlining the Path From Chemistry to Biology in Drug Discovery. [PDF]
ChemMedChemCrude yet clever: Direct‐to‐biology workflows exploit nanoscale synthesis and plate‐based assays to accelerate hit discovery, save precious intermediates, and rethink early drug discovery. Direct‐to‐biology (D2B) has emerged as a transformative concept in early drug discovery, defined by the direct on‐target screening of crude reaction mixtures without
Hübner AF, Barthels F.
europepmc +2 more sources
Polymeric Blatter's Radical via CuAAC and ROMP [PDF]
Macromolecular Chemistry and Physics, 2021 AbstractA Blatter radical‐containing polymer backbone is synthesized via copper‐catalyzed azide‐alkyne cycloaddition (CuAAC) and consecutive ring‐opening metathesis polymerization. For this, an alkyne‐functionalized Blatter radical is synthesized and used for the described CuAAC, yielding a polymerizable derivative of the radical. The resulting polymer
Adrian Saal +2 more
openaire +1 more source