Results 51 to 60 of about 9,957 (210)

A Cascade Recognition of Activatable Probe for Fluorescence Navigation Glioblastoma Surgery: Overcoming Blood‐Brain Barrier and Off‐Target Limitations

Advanced Science, EarlyView.
A cascade recognition of activatable probe ANG‐hCy‐MC is used for high‐precision depiction of glioblastoma (GBM) margin. This probe crosses the blood‐brain barrier (BBB) through LRP1 receptor‐mediated transport and provides excellent fluorescence signal contrast between the tumor and normal tissues, thereby enabling ultra‐selective imaging and precise ...
Xinru An, Yu Guo, Yongning Bian, Yanli Tan, Chuan Fang, Hengzhu Zhang, Xueqian Chen, Lin Yuan, Dongdong Su   +8 more
wiley   +1 more source

Development of Novel Immobilized Copper–Ligand Complex for Click Chemistry of Biomolecules

Molecules
Copper-catalyzed azide–alkyne cycloaddition click (CuAAC) reaction is widely used to synthesize drug candidates and other biomolecule classes. Homogeneous catalysts, which consist of copper coordinated to a ligand framework, have been optimized for high ...
Rene Kandler, Yomal Benaragama, Manoranjan Bera, Caroline Wang, Rasheda Aktar Samiha, W. M. C. Sameera, Samir Das, Arundhati Nag   +7 more
doaj   +1 more source

Synthesis of fluorinated polypropylene using CuAAC click chemistry

Journal of Applied Polymer Science, 2018
ABSTRACTSynthesis of fluorine containing polypropylene (PPF) from chlorinated polypropylene (PPCl) via Cu(I) catalyzed Huisgen type 1,3‐dipolar cycloaddition (CuAAC) and its water repellency properties are demonstrated. Initially, clickable azido‐functional polypropylene (PPN3) and alkyne‐functionalized fluorine compound (FAl) are independently ...
G. Acik, C. Elif Cansoy, M. A. Tasdelen
openaire   +2 more sources

One‐Step Glycoengineering of NK Cells With High‐Affinity Siglec Ligands for Cancer Immunotherapy

Advanced Science, EarlyView.
This study develops an engineered NmCSS enzyme with improved activity for bulky group modified sialic acids, enabling efficient synthesis of structurally diverse sialoside analogs in a single step. Glycan microarray screening identified Siglec high‐affinity ligands, which were incorporated onto natural killer (NK) cells via a one‐pot enzymatic system ...
Shuai Hu, Ben Huang, Lingyan Wang, Qiang Guo, Cuiping Jiang, Ruicheng Qi, Shuyao Wang, Lin‐Tai Da, Wenjie Peng   +8 more
wiley   +1 more source

Post-Functionalization of Organometallic Complexes via Click-Reaction

Molecules, 2022
CuAAC (Cu catalyzed azide-alkyne cycloaddition) click-reaction is a simple and powerful method for the post-synthetic modification of organometallic complexes of transition metals. This approach allows the selective introduction of additional donor sites
Stanislav Petrovskii, Viktoria Khistiaeva, Aleksandra Paderina, Evgenia Abramova, Elena Grachova   +4 more
doaj   +1 more source

Synthesis of substituted triazole–pyrazole hybrids using triazenylpyrazole precursors

Beilstein Journal of Organic Chemistry
A synthesis route to access triazole–pyrazole hybrids via triazenylpyrazoles was developed. Contrary to existing methods, this route allows the facile N-functionalization of the pyrazole before the attachment of the triazole unit via a copper-catalyzed ...
Simone Gräßle, Laura Holzhauer, Nicolai Wippert, Olaf Fuhr, Martin Nieger, Nicole Jung, Stefan Bräse   +6 more
doaj   +1 more source

Green Methodologies for Copper(I)-Catalyzed Azide-Alkyne Cycloadditions: A Comparative Study

Molecules, 2019
Successful copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reactions may be achieved by several methods. In this paper, four synthetic protocols were performed for direct comparison of time required for the synthesis, yield, and purity of the 1H-1,
Marissa Trujillo, Clayton Hull-Crew, Andrew Outlaw, Kevin Stewart, Loren Taylor, Laura George, Allison Duensing, Breanna Tracey, Allen Schoffstall   +8 more
doaj   +1 more source

Tandem Photoinduced Cationic Polymerization and CuAAC for Macromolecular Synthesis

Macromolecules, 2015
A novel synthetic strategy involving sequential photoinduced cationic and copper-catalyzed azide–alkyne cycloaddition (CuAAC) click processes for the synthesis of complex macromolecular structures such as side-chain functional polymers, graft copolymers, and organogels is described.
Doran, Sean, Yilmaz, Gorkem, Yagci, Yusuf   +2 more
openaire   +2 more sources

Copper-Catalyzed Azide–Alkyne Cycloaddition-Oriented Multifunctional Bio-Orthogonal Linker BPPA: Design, Synthesis and Evaluation

Molecules, 2023
The multifunctional linker molecules are crucial for the bio-orthogonal reaction for proteomic target profiling. Herein, we wish to present a novel type of biotin-based tetra-functional bio-orthogonal linkers 3a–3h named BPPA which, possessing a unique ...
Shuo Wang, Xu He, Junchen Li, Enxue Shi
doaj   +1 more source

Fabrication of Lignocellulose-Based Microreactors: Copper-Functionalized Bamboo for Continuous-Flow CuAAC Click Reactions

ACS Sustainable Chemistry and Engineering, 2019
The fabrication of a new copper-functionalized lignocellulosic microreactor (Cu-LμR) from bamboo culms is herein described together with its operation to perform a copper(I)-catalyzed 1,3-dipolar cycloaddition between azide and terminal alkyne (CuAAC ...
Druval Santos de Sá, Rodrigo de Andrade Bustamante, Carlos Eduardo Rodrigues Rocha, V. D. da Silva, Elton Jorge da Rocha Rodrigues, Camilla Djenne Buarque Müller, Khosrow Ghavami, A. Massi, Omar Ginoble Pandoli   +8 more
semanticscholar   +1 more source