Results 1 to 10 of about 20,675 (236)

Cucurbitacin IIb alleviates colitis via regulating gut microbial composition and metabolites [PDF]

Heliyon
Cucurbitacin IIb, a member of the triterpenoid family, exerts beneficial effects on intestinal diseases, including enteritis and bacillary dysentery. However, its effects and mechanisms of action on colitis have not yet been explored.
Yinyin Zhao, Kangxiao Guo, Yongwang Yan, Binyuan Jiang   +3 more
doaj   +3 more sources

Uncovering the anti-cancer mechanism of cucurbitacin D against colorectal cancer through network pharmacology and molecular docking [PDF]

Discover Oncology
Colorectal cancer is a significant global health challenge due to chemoresistance, necessitating new treatments. Cucurbitacin D, with its anti-cancer properties, shows promise, but its effects on colorectal cancer are not well understood. We investigated
Hae-In Lim, Ga Yoon Kim, Yu-Jeong Choi, Kangwook Lee, Seong-Gyu Ko   +4 more
doaj   +3 more sources

Cucurbitacin B and Its Derivatives: A Review of Progress in Biological Activities [PDF]

Molecules
The emergence of natural products has provided extremely valuable references for the treatment of various diseases. Cucurbitacin B, a tetracyclic triterpenoid compound isolated from cucurbitaceae and other plants, is the most abundant member of the ...
Wenzhe Nie, Yalan Wang, Xinlu Tian, Jinying Liu, Zhanhui Jin, Junjie Xu, Miaohai He, Qingkun Shen, Hongyan Guo, Tian Luan   +9 more
doaj   +3 more sources

Cucurbitacin E reduces IL-1β-induced inflammation and cartilage degeneration by inhibiting the PI3K/Akt pathway in osteoarthritic chondrocytes

Journal of Translational Medicine, 2023
Background Osteoarthritis is a degenerative joint disease. Cartilage degeneration is the earliest and most important pathological change in osteoarthritis, and persistent inflammation is one of the driving factors of cartilage degeneration.
Lin Wang, Hui Xu, Xin Li, Hongwei Chen, Haigang Zhang, Xunpeng Zhu, Zhijie Lin, Shilei Guo, Zhibo Bao, Haicheng Rui, Wei He, Hui Zhang   +11 more
doaj   +2 more sources

Reduction of Cancer Stem Cells and Invasiveness of Human Melanoma and Breast Cancer by Cucurbitacin B from Lagenaria siceraria

Drugs and Drug Candidates, 2023
Cucurbitacins are secondary metabolites that are commonly found in the Cucurbitacae family. Many biological properties have been reported for cucurbitacins, including anti-inflammatory, antioxidant, antiviral, anti-malaria, and anticancer properties ...
Cheng-Chen Huang, Kiera K. Balding, Sydney J. Zimmerman, Che-Yuan Chang, Si-Min Lu, Hui-Chi Huang   +5 more
doaj   +2 more sources

Metabolome and Transcriptome Analyses of Cucurbitacin Biosynthesis in Luffa (Luffa acutangula)

Frontiers in Plant Science, 2022
Cucurbitacins are extremely bitter compounds mainly present in Cucurbitaceae, where Luffa belongs. However, there is no comprehensive analysis of cucurbitacin biosynthesis in Luffa fruit.
Gangjun Zhao, Meng Wang, Caixia Luo, Junxing Li, Hao Gong, Xiaoming Zheng, Xiaoxi Liu, Jianning Luo, Haibin Wu, Haibin Wu   +9 more
doaj   +2 more sources

Comparison of the pharmacokinetic profiles of three triterpenoids after oral administration of a cucurbitacin tablet and nanosuspension by UHPLC-MS/MS [PDF]

Frontiers in Pharmacology
IntroductionCucurbitacin, a class of triterpenoid compounds isolated from Pedicellus Melo, possesses various biological activities and is the primary active component of cucurbitacin tablets (CUT) used to treat chronic hepatitis and primary liver cancer.
Chun-nan Zhang, Zhi-bin Wang, Rui-tong Du, Shu-lu Zhang, Chu-qiao Wang, Meng Wang, Li-hong Wu, De-qiang Yang, Chen Wang   +8 more
doaj   +2 more sources

The involvement of the noradrenergic system in the antinociceptive effect of cucurbitacin D on mice with paclitaxel-induced neuropathic pain

Frontiers in Pharmacology, 2023
Paclitaxel (sold under the brand name Taxol) is a chemotherapeutic drug that is widely used to treat cancer. However, it can also induce peripheral neuropathy, which limits its use.
Keun-Tae Park, Suyong Kim, Ilseob Choi, Ik-Hwan Han, Hyunsu Bae, Woojin Kim, Woojin Kim   +6 more
doaj   +2 more sources

Anti-metastatic Potential of Natural Triterpenoid Cucurbitacin B Against Cholangiocarcinoma Cells by Targeting Src Protein

Integrative Cancer Therapies, 2022
Owing to the crucial role of Src in cancer metastasis, interruption of Src and its signaling has been considered a promising strategy for cancer metastasis treatment.
Putthaporn Kaewmeesri MS, Piman Pocasap PhD, Veerapol Kukongviriyapan PhD, Auemduan Prawan PhD, Sarinya Kongpetch PhD, Laddawan Senggunprai PhD   +5 more
doaj   +2 more sources

Cucurbitacin E Alleviates Colonic Barrier Function Impairment and Inflammation Response and Improves Microbial Composition on Experimental Colitis Models

Journal of Inflammation Research
Fengxia Zhan,1 Wei Song,2 Yong Fan,3 Fangjian Wang,1 Qian Wang4,5 1Department of Clinical Laboratory, Hospital of Shandong University, Jinan, 250100, People’s Republic of China; 2Key Laboratory of Marine Eco-Environmental Science and Technology, First ...
Zhan F, Song W, Fan Y, Wang F, Wang Q
doaj   +2 more sources