Results 31 to 40 of about 20,694 (254)
International Journal of Immunopathology and Pharmacology, 2018 Cucurbitacins are triterpenoids commonly found in Cucurbitaceae and Cruciferae and have long been used in traditional medicine. Cucurbitacins demonstrate anti-inflammatory and anti-cancer activities.
Jin Mo Ku +8 more
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Cucurbitacin I inhibits cell motility by indirectly interfering with actin dynamics. [PDF]
PLoS ONE, 2010 Cucurbitacins are plant natural products that inhibit activation of the Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) pathway by an unknown mechanism.
David A Knecht +6 more
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Cell Death and Disease, 2021 Cucurbitacin B (CuB) is a widely available triterpenoid molecule that exhibits various biological activities. Previous studies on the anti-tumour mechanism of CuB have mostly focused on cell apoptosis, and research on the ferroptosis-inducing effect has ...
Shuai Huang +10 more
semanticscholar +1 more source
Enhanced antitumor activity of cucurbitacin B combined with cerulenin in osteosarcoma
Bangladesh Journal of Pharmacology, 2015 In the present study, the effect of cucurbitacin B and cerulenin combination on osteosarcoma was investigated to develop an effective treatment regimen.
Zhe Zhang, Ying Shen, Jian Wu, Lin Cai
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Toxins, 2022 We examined a two-step target protein binding strategy that uses cofilin as the target protein to analyze the active constituents in Bryonia cretica. In the first step, we prepared the target protein, and used it to analyze the compounds binding to it in
Souichi Nakashima +6 more
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A Systematic Review of Iran’s Medicinal Plants With Anticancer Effects [PDF]
, 2015 Increase in cases of various cancers has encouraged the researchers to discover novel, more effective drugs from plant sources. This study is a review of medicinal plants in Iran with already investigated anticancer effects on various cell lines.
Asadi-Samani, Majid. +3 more
core +1 more source
Migrastatics—anti-Metastatic and Anti-invasion Drugs:Promises and Challenges [PDF]
, 2017 In solid cancers, invasion and metastasis account for more than 90% of mortality. However, in the current armory of anticancer therapies, a specific category of anti-invasion and antimetastatic drugs is missing.
Gandalovičová, Aneta +9 more
core +1 more source
International Journal of Neuropsychopharmacology, 2023 Background Although depression has been a serious neuropsychiatric disorder worldwide, current antidepressants used in clinical practice have various weaknesses, including delayed onset and low rates of efficacy.
Jian-bin Ge +6 more
semanticscholar +1 more source
BMC Complementary and Alternative Medicine, 2012 Background Cucurbitacin B, an oxygenated tetracyclic triterpenoid compound extracted from the Thai medicinal plant Trichosanthes cucumerina L., has been reported to have several biological activities including anti-inflammatory, antimicrobial and ...
Duangmano Suwit +4 more
doaj +1 more source
Cucurbitacin E and I target the JAK/STAT pathway and induce apoptosis in Sézary cells
Biochemistry and Biophysics Reports, 2020 Cutaneous T-cell lymphomas and leukemias (CTCLs) are a heterogeneous group of extranodal non-Hodgkin's lymphomas. These are characterized by an accumulation of malignant CD4+ T-lymphocytes in the skin, lymph nodes, and peripheral blood.
Isabella J. Brouwer +3 more
doaj +1 more source