Cucurbitacin B and Its Derivatives: A Review of Progress in Biological Activities [PDF]
MoleculesThe emergence of natural products has provided extremely valuable references for the treatment of various diseases. Cucurbitacin B, a tetracyclic triterpenoid compound isolated from cucurbitaceae and other plants, is the most abundant member of the ...
Wenzhe Nie +9 more
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Pharmacokinetics of cucurbitacin B from Trichosanthes cucumerina L. in rats [PDF]
BMC Complementary and Alternative Medicine, 2019 Background Cucurbitacin B is the major bioactive constituent in Trichosanthes cucumerina L. fruits, which the pharmacological properties have been studied for decades particularly an anti-tumor activity.
Natthaphon Hunsakunachai +4 more
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Cucurbitacin B induces oral squamous cell carcinomapyroptosis via GSDME and inhibits tumour growth [PDF]
Translational OncologyBackground: Pyroptosis, a form of programmed cell death, has been shown to induce anti-tumour immunity and inhibit tumour growth. Oral squamous cell carcinoma (OSCC), a prevalent malignant tumour, could benefit from pyroptosis induction as a therapeutic ...
Xin Chen +9 more
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Synthesis of Cucurbitacin B Derivatives as Potential Anti-Hepatocellular Carcinoma Agents [PDF]
Molecules, 2018 Cucurbitacin B shows potent activity against tumor cells, but its high toxicity limits its application in the clinic. A series of cucurbitacin B derivatives was synthesized and evaluated for their anti-hepatocellular carcinoma (HCC) activities against ...
Weizhi Ge +8 more
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Cucurbitacin B Exhibits Antitumor Effects on Chordoma Cells via Disruption of Brachyury. [PDF]
Int J Mol SciChordomas are rare malignant tumors of the bone, originating from remnants of notochordal cells. The transcription factor brachyury, encoded by TBXT, serves as a critical diagnostic marker and is essential for tumor growth.
Seeling C +7 more
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Recent Advances in the Application of Cucurbitacin B as an Anticancer Agent. [PDF]
Int J Mol SciCucurbitacin B (CuB), a tetracyclic triterpenoid compound isolated from Cucurbitaceae plants, exhibits inhibitory effects on various tumor cells (e.g., liver, gastric, and colorectal cancer cells).
Yin D +10 more
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Anti-metastatic Potential of Natural Triterpenoid Cucurbitacin B Against Cholangiocarcinoma Cells by Targeting Src Protein [PDF]
Integrative Cancer Therapies, 2022 Owing to the crucial role of Src in cancer metastasis, interruption of Src and its signaling has been considered a promising strategy for cancer metastasis treatment.
Putthaporn Kaewmeesri MS +5 more
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Cucurbitacin-B instigates intrinsic apoptosis and modulates Notch signaling in androgen-dependent prostate cancer LNCaP cells. [PDF]
Front Pharmacol, 2023 Introduction: Among numerous triterpenoids of the Cucurbitaceae family, Cucurbitacin-B (Cur-B) is being explored for its pharmacological attributes. Reports from previous studies have explicitly shown that Cur-B possesses substantial anticancer effects ...
Alafnan A +3 more
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Cucurbitacin B Exerts Significant Antidepressant-Like Effects in a Chronic Unpredictable Mild Stress Model of Depression: Involvement of the Hippocampal BDNF-TrkB System. [PDF]
Int J Neuropsychopharmacol, 2023 Background Although depression has been a serious neuropsychiatric disorder worldwide, current antidepressants used in clinical practice have various weaknesses, including delayed onset and low rates of efficacy.
Ge JB +6 more
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Cucurbitacin B induces apoptosis in colorectal cells through reactive oxygen species generation and endoplasmic reticulum stress pathways. [PDF]
Exp Ther Med, 2023 Cucurbitacin B (CuB) is a member of the cucurbitacin family, which has shown potent anticancer pharmacological activity. Prolonged or severe endoplasmic reticulum stress (ERS) induces apoptosis; therefore, the present study investigated whether CuB may ...
Huang JL +5 more
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