Results 11 to 20 of about 13,244,565 (235)

Cucurbitacin B Down-Regulates TNF Receptor 1 Expression and Inhibits the TNF-α-Dependent Nuclear Factor κB Signaling Pathway in Human Lung Adenocarcinoma A549 Cells. [PDF]

Int J Mol Sci, 2022
Pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), induce the expression of intracellular adhesion molecule-1 (ICAM-1) by activating the nuclear factor κB (NF-κB) signaling pathway.
Kusagawa E, Okuda C, Yamaguchi R, Nakano K, Miyake Y, Kataoka T.   +5 more
europepmc   +4 more sources

Cucurbitacin B: A Review of its Pharmacology, Toxicity, and Pharmacokinetics.

Pharmacological Research, 2022
Cucurbitacin B (CuB, C32H46O8), the most abundant and active member of cucurbitacins, which are highly oxidized tetracyclic triterpenoids. Cucurbitacins are widely distributed in a variety of plants and mainly isolated from plants in the Cucurbitaceae ...
Shuang-Hua Dai, Cheng Wang, Xingtao Zhao, Cheng Ma, Ke Fu, Yanfang Liu, Cheng Peng, Yunxia Li   +7 more
semanticscholar   +3 more sources

The Antiproliferative and Proapoptotic Effects of Cucurbitacin B on BPH-1 Cells via the p53/MDM2 Axis. [PDF]

Int J Mol Sci, 2023
Cucurbitacin B (Cu B), a triterpenoid compound, has anti-inflammatory and antioxidant activities. Most studies only focus on the hepatoprotective activity of Cu B, and little effort has been geared toward exploring the effect of Cu B on the prostate. Our
Zhou P, Huang S, Shao C, Huang D, Hu Y, Su X, Yang R, Jiang J, Wu J.   +8 more
europepmc   +2 more sources

Cucurbitacin B from Cucurbitaceae Plants: Treating Pancreatic Cancer via Inducing Mitophagy, Inhibiting Glycolysis, and Enhancing Immune Function. [PDF]

Nutrients
Background: Cucurbitacin B (CuB) is a relatively unique and valuable component in plants of the Cucurbitaceae family due to its diverse and remarkable physiological activities, but its specific mechanisms in regulating tumor metabolism and immune ...
Yin D, Chen H, Jing X, Lin S, Sun Y, Chang R, Feng Y, Dong X, Qu C, Ni J, Yin X.   +10 more
europepmc   +2 more sources

Cucurbitacin B alleviates DSS-induced ulcerative colitis by improving gut microbiota disorder in C57BL/6 mice. [PDF]

AMB Express
Cucurbitacin B (CuB) is a triterpenoid compound derived from various medicinal plants, demonstrating potential anti-inflammatory, antioxidant, and neuroprotective properties, as well as significant anti-tumor effects.
Li J, Shen X, Wu X, Zhao F, Tang W, Wu M, Hu F, Hu X, Wang F, Zhang Q.   +9 more
europepmc   +2 more sources

Reduction of Cancer Stem Cells and Invasiveness of Human Melanoma and Breast Cancer by Cucurbitacin B from Lagenaria siceraria

Drugs and Drug Candidates, 2023
Cucurbitacins are secondary metabolites that are commonly found in the Cucurbitacae family. Many biological properties have been reported for cucurbitacins, including anti-inflammatory, antioxidant, antiviral, anti-malaria, and anticancer properties ...
Cheng-Chen Huang, Kiera K. Balding, Sydney J. Zimmerman, Che-Yuan Chang, Si-Min Lu, Hui-Chi Huang   +5 more
doaj   +2 more sources

Cucurbitacin B-induced G2/M cell cycle arrest of conjunctival melanoma cells mediated by GRP78-FOXM1-KIF20A pathway. [PDF]

Acta Pharm Sin B, 2022
Conjunctival melanoma (CM) is a rare and fatal malignant eye tumor. In this study, we deciphered a novel anti-CM mechanism of a natural tetracyclic compound named as cucurbitacin B (CuB).
Wei J, Chen X, Li Y, Li R, Bao K, Liao L, Xie Y, Yang T, Zhu J, Mao F, Ni S, Jia R, Xu X, Li J.   +13 more
europepmc   +2 more sources

Cucurbitacin B inhibits TGF-β1-induced epithelial-mesenchymal transition (EMT) in NSCLC through regulating ROS and PI3K/Akt/mTOR pathways. [PDF]

Chin Med, 2022
Background Lung cancer is the leading cause of cancer mortality worldwide, and most of the patients after treatment with EGF-TKIs develop drug resistance, which is closely correlated with EMT. Cucurbitacin B (CuB) is a natural product of the Chinese herb
Yuan R, Fan Q, Liang X, Han S, He J, Wang QQ, Gao H, Feng Y, Yang S.   +8 more
europepmc   +2 more sources

Cucurbitacin B inhibits Th17 cell differentiation via the suppression of the JAK/STAT pathway and alleviates collagen-induced arthritis in mice. [PDF]

Int J Immunopathol Pharmacol
Objective: Rheumatoid arthritis (RA) is a chronic autoimmune disease with limited treatment options and associated side effects or resistance. This study aims to investigate the therapeutic potential of the natural compound cucurbitacin B (CuB) in RA ...
Kung SP, Umbreen H, Wang JH, Tsia CM, Lin TC, Chen YT.   +5 more
europepmc   +2 more sources

Cucurbitacin B Inhibits the Proliferation of WPMY-1 Cells and HPRF Cells via the p53/MDM2 Axis. [PDF]

Int J Mol Sci
Modern research has shown that Cucurbitacin B (Cu B) possesses various biological activities such as liver protection, anti-inflammatory, and anti-tumor effects. However, the majority of research has primarily concentrated on its hepatoprotective effects,
Jin Y, Zhou P, Huang S, Shao C, Huang D, Su X, Yang R, Jiang J, Wu J.   +8 more
europepmc   +2 more sources