VASP activation via the Gα13/RhoA/PKA pathway mediates cucurbitacin-B-induced actin aggregation and cofilin-actin rod formation. [PDF]
PLoS ONE, 2014 Cucurbitacin B (CuB), a potent antineoplastic agent of cucurbitacin triterpenoids, induces rapid disruption of actin cytoskeleton and aberrant cell cycle inhibiting carcinogenesis.
Yan-Ting Zhang +8 more
doaj +7 more sources
Induction of ferroptosis in human nasopharyngeal cancer cells by cucurbitacin B: molecular mechanism and therapeutic potential. [PDF]
Cell Death Dis, 2021 Cucurbitacin B (CuB) is a widely available triterpenoid molecule that exhibits various biological activities. Previous studies on the anti-tumour mechanism of CuB have mostly focused on cell apoptosis, and research on the ferroptosis-inducing effect has ...
Huang S +10 more
europepmc +2 more sources
Cucumber-Derived Nanovesicles Containing Cucurbitacin B for Non-Small Cell Lung Cancer Therapy [PDF]
International Journal of Nanomedicine, 2022 Tingting Chen,1,2,* Bingxiang Ma,1,2,* Shi Lu,1,2 Lupeng Zeng,1,2 Huaying Wang,1,2 Wanhua Shi,1,2 Linying Zhou,3 Yaokun Xia,4 Xi Zhang,1 Jing Zhang,5 Jinghua Chen1 1School of Pharmacy, Fujian Medical University, Fuzhou, Fujian Province, 350108 ...
Chen T +10 more
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The effectiveness of cucurbitacin B in BRCA1 defective breast cancer cells. [PDF]
PLoS ONE, 2013 Cucurbitacin B (CuB) is one of the potential agents for long term anticancer chemoprevention. Cumulative evidences has shown that cucurbitacin B provides potent cellular biological activities such as hepatoprotective, anti-inflammatory and antimicrobial ...
Moltira Promkan +4 more
doaj +4 more sources
Cucurbitacin B regulates lung cancer cell proliferation and apoptosis via inhibiting the IL-6/STAT3 pathway through the lncRNA XIST/miR-let-7c axis. [PDF]
Pharm Biol, 2022 Context Lung cancer, the most common type of cancer, has a high mortality rate. Cucurbitacin B (CuB), a natural compound extracted from Cucurbitaceae plants, has antitumor effects.
Liu JH, Li C, Cao L, Zhang CH, Zhang ZH.
europepmc +2 more sources
PLGA/β-TCP composite scaffold incorporating cucurbitacin B promotes bone regeneration by inducing angiogenesis. [PDF]
J Orthop Translat, 2021 Objectives Vascularization is an essential step in successful bone tissue engineering. The induction of angiogenesis in bone tissue engineering can be enhanced through the delivery of therapeutic agents that stimulate vessel and bone formation.
Cheng WX +12 more
europepmc +2 more sources
Cucurbitacin-B Exerts Anticancer Effects through Instigation of Apoptosis and Cell Cycle Arrest within Human Prostate Cancer PC3 Cells via Downregulating JAK/STAT Signaling Cascade. [PDF]
Pharmaceuticals (Basel), 2022 Cucurbitacin-B (Cur-B) is an analogue triterpenoid belonging to the Cucurbitaceae family. Previous reports have explicitly outlined various biological activities of Cucurbitaceae family members, including the anticancer activity of Cur-B.
Alafnan A +3 more
europepmc +2 more sources
Preparation, characterization and pharmacokinetics of Cucurbitacin B solid dispersion
OpenNano, 2022 Cucurbitacin B (CuB) is a type of tetracyclic triterpenoids derived from the Cucurbitaceae melon, which has various biological activities. However, the poor water solubility and low bioavailability of CuB limit its wide range of clinical applications ...
Qian Wu +6 more
doaj +2 more sources
Cucurbitacin B suppresses glioblastoma via the STAT3/ROS/endoplasmic reticulum stress pathway [PDF]
Scientific ReportsCucurbitacin B (CuB), the tetracyclic triterpenoid compound belonging to cucurbitaceae family, demonstrates significant anticancer properties across various tumor types.
Guangyao Lv +8 more
doaj +2 more sources
Impact of the secondary plant metabolite Cucurbitacin B on the demographical traits of the melon aphid, Aphis gossypii [PDF]
Scientific Reports, 2018 Cucurbitacin B is a natural triterpene present in plants of Cucurbitaceae family, which are among the host plants for melon aphid, Aphis gossypii. In present study we characterized the effects of two cucurbitacin B concentrations on the biological ...
Hafiz Kamran Yousaf +7 more
doaj +2 more sources