Induction of the STING-dependent DNA damage pathway by cucurbitacin B enhances immunotherapy efficacy in osteosarcoma [PDF]
Iranian Journal of Basic Medical SciencesObjective(s): Osteosarcoma (OS) is a highly aggressive bone tumor with limited therapeutic options. Cucurbitacin B (CuB), a natural compound derived from Cucurbitaceae plants, has demonstrated antitumor activity in various malignancies; however, its ...
Bin Luo +5 more
doaj +2 more sources
Frontiers in Bioscience-Landmark, 2022 Background: Alzheimer’s disease (AD) type dementia encompasses diverse cognitive deficits marked by free radicals and pro-inflammatory cytokines mediated progressive neurodegeneration and vascular damage including the blood-brain barrier.
Zhiyong Liu, Manish Kumar, Atul Kabra
doaj +2 more sources
Correction: Cucurbitacin B inhibits TGF-β1-induced epithelial-mesenchymal transition (EMT) in NSCLC through regulating ROS and PI3K/Akt/mTOR pathways. [PDF]
Chin MedYuan R +8 more
europepmc +2 more sources
Chloroform Fraction of Cucumis melo L. ‘Gama Melon Parfum’ Cytotoxicity against Breast Cancer Cell T47D and MCF7 [PDF]
BIO Web of Conferences, 2022 Nature is the source of various types of phytochemicals. Some of them are unique chemical compounds only found in certain plants. For example, Cucurbitacin is found in the family Cucurbitaceae.
Salamah Rohmi, Widiyanto Slamet
doaj +1 more source
Cucurbitacins: A Focus on Cucurbitacin E As A Natural Product and Their Biological Activities [PDF]
Pharmaceutical Sciences, 2020 For the last years, different types of cucurbitacins have been extracted from various species of Cucurbitaceae family. For this review, all related papers were accumulated by searching electronic databases in the English language, including PubMed, Scopus, and Google Scholar. The keywords of cucurbitacin, cucumber anticancer therapy, cytotoxic effects,
Moazzameh Ramezani +3 more
openaire +2 more sources
Cucurbitacins: elucidation of their interactions with the cytoskeleton [PDF]
PeerJ, 2017 Cucurbitacins, a class of toxic tetracyclic triterpenoids in Cucurbitaceae, modulate many molecular targets. Here we investigated the interactions of cucurbitacin B, E and I with cytoskeletal proteins such as microtubule and actin filaments.
Xiaojuan Wang +3 more
doaj +2 more sources
تشخیص بعض الاحماض الدهنیة ومرکب Cucurbitacin فی مستخلص زیت بعض اجزاء وکالس نبات القرع الجبلی Cucurbita maxima [PDF]
مجلة ابحاث كلية التربية الاساسية, 2021 استخلص زیت نبات القرع الجبلیC.maxima وقدرت نسب وجوده فی الجذور وفی قطع الاوراق والسیقان تحت الفلقیة وفی کالس هذه الاجزاء کنسبة مئویة، وتمکنت الدراسة من تشخیص الاحماض الدهنیة Linolic acid, Oleic acid, Stearic acid, Palmitic acid ، فضلاً عن تشخیص ثلاث ...
islam abdullah
doaj +1 more source
Frontiers in Pharmacology, 2023 Paclitaxel (sold under the brand name Taxol) is a chemotherapeutic drug that is widely used to treat cancer. However, it can also induce peripheral neuropathy, which limits its use.
Keun-Tae Park +6 more
doaj +1 more source
Metabolome and Transcriptome Analyses of Cucurbitacin Biosynthesis in Luffa (Luffa acutangula)
Frontiers in Plant Science, 2022 Cucurbitacins are extremely bitter compounds mainly present in Cucurbitaceae, where Luffa belongs. However, there is no comprehensive analysis of cucurbitacin biosynthesis in Luffa fruit.
Gangjun Zhao +9 more
doaj +1 more source
Cucurbitacin E has neuroprotective properties and autophagic modulating activities on dopaminergic neurons [PDF]
, 2014 Natural molecules are under intensive study for their potential as preventive and/or adjuvant therapies for neurodegenerative disorders such as Parkinson’s disease (PD).
Arel-Dubeau, Anne-Marie +8 more
core +8 more sources