Treadmill Exercise Impact on Brain Electrophysiological and Glial Immunoreactivity in Cuprizone-Treated Rats [PDF]
Brain SciencesBackground/Objectives: Demyelination occurs to a variable extent in various neurological diseases, such as multiple sclerosis. Physical exercise benefits central neural functions that depend on the brain’s electrophysiological and glial activity.
Cássia Borges Lima-de-Castro +5 more
doaj +4 more sources
An Alternative Cuprizone-Induced Demyelination and Remyelination Mouse Model [PDF]
ASN Neuro, 2017 The cuprizone model is a well-established and investigated paradigm to study demyelination and remyelination in rodents. Cuprizone is usually administrated by mixing in the powdered or pelleted rodent chow.
Wei Zhen +5 more
doaj +2 more sources
In Vivo Measurement of Neurochemical Abnormalities in the Hippocampus in a Rat Model of Cuprizone-Induced Demyelination [PDF]
Diagnostics, 2020 This study quantitatively measured the changes in metabolites in the hippocampal lesions of a rat model of cuprizone-induced demyelination as detected using in vivo 7 T proton magnetic resonance spectroscopy.
Do-Wan Lee +7 more
doaj +2 more sources
Effect of swimming on oligodendrocytic cells and myelin tissue in corpus callosum of rat model of MS induced by Cuprizone [PDF]
مجله پزشکی دانشگاه علوم پزشکی تبریز, 2021 Background: Multiple Sclerosis is a myelin destroyer disease, which physical activity can be effective in improving it. Therefore, in the present study, the effect of swimming on oligodendrocytic cells and myelin tissue in rat brain of the Cuprizone ...
Ebrahim Bagheri +3 more
doaj +2 more sources
Protective effects of erythropoietin against cuprizone-induced oxidative stress and demyelination in the mouse corpus callosum [PDF]
Iranian Journal of Basic Medical Sciences, 2017 Objective(s): Increasing evidence in both experimental and clinical studies suggests that oxidative stress plays a major role in the pathogenesis of multiple sclerosis.
Iraj Ragerdi Kashani +7 more
doaj +3 more sources
3D inversion recovery ultrashort echo time MRI can detect demyelination in cuprizone-treated mice [PDF]
Frontiers in NeuroimagingPurposeTo test the ability of inversion-recovery ultrashort echo time (IR-UTE) MRI to directly detect demyelination in mice using a standard cuprizone mouse model.MethodsNon-aqueous myelin protons have ultrashort T2s and are “invisible” with conventional
Adam C. Searleman +11 more
doaj +2 more sources
Melatonin ameliorates astrogliosis and microgliosis in a cuprizone demyelinating mouse model [PDF]
Biochemistry and Biophysics ReportsBackground and purpose: Several investigations have reported that melatonin is involved in the amelioration of the inflammatory process, improvement of myelin function, and regeneration in the central nervous system (CNS).
Mehdi Alidadi +5 more
doaj +2 more sources
Pilot functional magnetic resonance imaging study of clemastine‐aided functional recovery on a mouse model of demyelination [PDF]
NeuroprotectionBackground Multiple sclerosis (MS) is a chronic demyelinating disease characterized by autoimmune attacks on myelin sheaths. Its deleterious effects may be reversed by remyelination, a process that restores the integrity of myelin sheaths and ...
Ander Egimendia +6 more
doaj +2 more sources
Cuprizone feed formulation influences the extent of demyelinating disease pathology
Scientific Reports, 2021 Cuprizone is a copper-chelating agent that induces pathology similar to that within some multiple sclerosis (MS) lesions. The reliability and reproducibility of cuprizone for inducing demyelinating disease pathology depends on the animals ingesting ...
Lillian M. Toomey +9 more
doaj +1 more source
A Morphological and Behavioral Study of Demyelination and Remyelination in the Cuprizone Model: Insights into APLNR and NG2+ Cell Dynamics. [PDF]
Int J Mol SciLandzhov B +9 more
europepmc +3 more sources