Results 91 to 100 of about 9,893 (241)

Delayed Demyelination and Impaired Remyelination in Aged Mice in the Cuprizone Model

Cells, 2020
To unravel the failure of remyelination in multiple sclerosis (MS) and to test promising remyelinating treatments, suitable animal models like the well-established cuprizone model are required. However, this model is only standardized in young mice. This
Stefan Gingele, Florian Henkel, Sandra Heckers, Thiemo M. Moellenkamp, Martin W. Hümmert, Thomas Skripuletz, Martin Stangel, Viktoria Gudi   +7 more
doaj   +1 more source

The Extracellular Matrix Proteins Tenascin-C and Tenascin-R Retard Oligodendrocyte Precursor Maturation and Myelin Regeneration in a Cuprizone-Induced Long-Term Demyelination Animal Model [PDF]

, 2022
Juliane Bauch, Andréas Faissner
openalex   +1 more source

Recent Advances in Interventions Targeting Remyelination and a Systematic Review of Remyelinating Effects of Approved Disease‐Modifying Treatments for Multiple Sclerosis

European Journal of Neurology, Volume 32, Issue 11, November 2025.
ABSTRACT Background Regenerative strategies in progressive multiple sclerosis (MS) pose a significant unmet need. Combining immunomodulatory treatment with remyelinating interventions to target the complex underlying pathogenesis appeals as the next frontier in MS therapeutic developments.
Anna‐Victoria De Keersmaecker, Eline van Doninck, Inez Wens, Yousra El Ouaamari, Veronica Popescu, Guy Laureys, Melissa Cambron, Miguel D'Haeseleer, Lander Willem, Judith Derdelinckx, Tatjana Reynders, Barbara Willekens   +11 more
wiley   +1 more source

The Serum Lipid Profile of Relapsing Multiple Sclerosis Differs Reproducibly From Healthy Controls

Journal of Neurochemistry, Volume 169, Issue 11, November 2025.
Blood biomarkers that correlate with inflammatory demyelination or neurodegeneration are needed for early diagnosis and disease monitoring in multiple sclerosis. This study employed lipidomic analysis to identify serum lipids that are reproducibly altered in relapsing–remitting multiple sclerosis (RRMS) across two independent sample cohorts, finding ...
Lisa Shi, Laura Ghezzi, Georgia Watt, Drishya Mainali, Dana Perantie, Chiara Fenoglio, Collin Tran, Alexander Dupuy, Freda Passam, Monokesh K. Sen, Humphrey Chan, Samuel Kwok, Chenyu Wang, Michael Barnett, Todd Hardy, Laura Piccio, Anthony S. Don   +16 more
wiley   +1 more source

Synthetic microneurotrophins: Neurotrophin receptors for therapeutics of neurodegenerative diseases

British Journal of Pharmacology, Volume 182, Issue 19, Page 4466-4489, October 2025.
Neurodegenerative disorders are characterised by the chronic progressive degeneration of specific neuronal subtypes, neuroinflammation, myelin damage and synaptic loss. Despite their growing incidence, advancements in effective treatments remain limited, because of lack of knowledge for the aetiology of the diverse pathophysiology to design systematic ...
Ioanna Zota, Theodora Calogeropoulou, Konstantina Chanoumidou, Ioannis Charalampopoulos, Achille Gravanis   +4 more
wiley   +1 more source

The relevance of α-KLOTHO to the central nervous system: Some key questions [PDF]

, 2017
α-Klotho is well described as an anti-aging protein, with critical roles in kidney function as a transmembrane co-receptor for FGF23, and as a soluble factor in serum.
Berwick, Daniel Charles, Cararo-Lopes, Marina Minto, Kawamoto, Elisa Mitiko, Mazucanti, Caio Henrique Yokoyama, Scavone, Cristoforo   +4 more
core   +1 more source

CXCL10 Triggers Early Microglial Activation in the Cuprizone Model [PDF]

The Journal of Immunology, 2015
Abstract A broad spectrum of diseases is characterized by myelin abnormalities and/or oligodendrocyte pathology. In most, if not all, of these diseases, early activation of microglia occurs. Our knowledge regarding the factors triggering early microglia activation is, however, incomplete.
Clarner, T., Janssen, K., Nellessen, L., Stangel, M., Skripuletz, T., Krauspe, B., Hess, F.M., Denecke, B., Beutner, C., Linnartz-Gerlach, B., Neumann, H., Vallieres, L., Amor, S., Ohl, K., Tenbrock, K., Beyer, C., Kipp, M.   +16 more
openaire   +3 more sources

Noninvasive Brain Stimulation Protects Cognitive Impairment in i.c.v. STZ‐Injected Rats: Role of Adult Neurogenesis

European Journal of Neuroscience, Volume 62, Issue 8, October 2025.
17.96‐μT, 50‐Hz, 2‐h/day whole body magnetic field exposure for 14 days can cause cognitive improvement eliciting adult neurogenesis in dentate gyrus through modulating region‐specific glial‐redox axis in streptozotocin‐induced cognitive dysfunction similar to Alzheimer's type dementia.
Aasheesh Kumar, Avishek Roy, Vedant Karaddi, Suman Jain, Jatinder Katyal, Yogendra Kumar Gupta   +5 more
wiley   +1 more source

Tyro3 deletion is protective in experimental autoimmune encephalomyelitis

Immunology &Cell Biology, Volume 103, Issue 9, Page 857-870, October 2025.
Multiple sclerosis pathogenesis involves the complex interplay between the peripheral immune response and the central nervous system. Gas6 is a promising therapy to promote remyelination; however, Gas6 and its receptors (the TAM receptor family) are widely expressed in both immune cells and the central nervous system. Our study demonstrates that global
Michele D Binder, Mohammad Asadian, Darnell Leepel, Gerry ZM Ma, Andrea Aprico, Liz Barreto‐Arce, Trevor J Kilpatrick, Sarrabeth Stone   +7 more
wiley   +1 more source

Loss of Saltation and Presynaptic Action Potential Failure in Demyelinated Axons [PDF]

, 2017
In cortical pyramidal neurons the presynaptic terminals controlling transmitter release are located along unmyelinated axon collaterals, far from the original action potential (AP) initiation site, the axon initial segment (AIS). Once initiated, APs will
Maarten H. P. Kole, Marko A. Popovic, Mustafa S. Hamada   +2 more
core   +2 more sources