Results 11 to 20 of about 9,893 (241)
Strain differences in cuprizone induced demyelination [PDF]
Cell & Bioscience, 2017 Background Multiple sclerosis (MS) is a severe neurological disorder, characterized by demyelination of the central nervous system (CNS), and with a prevalence of greater than 2 million people worldwide.
Qili Yu +6 more
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Cuprizone Intoxication Results in Myelin Vacuole Formation [PDF]
Frontiers in Cellular Neuroscience, 2022 Myelin damage is a histopathological hallmark of multiple sclerosis lesions. Results of post mortem studies suggest that impaired myelin-axon interaction characterized by focal myelin detachments is an early event during lesion genesis. In this study, we
Sarah Joost +8 more
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Development and validation of a novel HILIC method for the quantification of low-levels of cuprizone in cuprizone-containing chow [PDF]
Scientific Reports, 2021 Cuprizone is an amide compound that has been wildly used in various animal studies, such as in the investigation of remyelination in mouse model. It is important to control the amount of cuprizone dosed in animals to be consistent as different amounts ...
Fengmei Zheng, Yiqing Lin, Pierre Boulas
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GAS6 enhances repair following cuprizone-induced demyelination. [PDF]
PLoS ONE, 2010 Growth arrest-specific protein 6 (gas6) activities are mediated through the Tyro3, Axl, and Mer family of receptor tyrosine kinases. Gas6 is expressed and secreted by a wide variety of cell types, including cells of the central nervous system (CNS).
Vladislav Tsiperson +4 more
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A New Model of Cuprizone-Mediated Demyelination/Remyelination
ASN Neuro, 2014 In the central nervous system, demyelinating diseases, such as multiple sclerosis, result in devastating long-term neurologic damage, in part because of the lack of effective remyelination in the adult human brain.
Hilary H. Sachs +4 more
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Depletion of Microglia Increases Cortical Oligodendrocyte Density During Remyelination. [PDF]
GliaCuprizone demyelination induces transient reactive states in deep cortical microglia (MG) through early recovery. Depleting MG in recovery increases the number of deep cortical mature/pre‐myelinating oligodendrocytes. Deep cortical reactive MG reduce oligodendrocyte density after demyelination.
Loo HK +5 more
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International Journal of Molecular Sciences, 2023 The Cuprizone mouse model is widely used in studies on de- and remyelination. In the hands of different experimenters, the Cuprizone concentrations that lead to comparable levels of demyelination differ considerably. The reasons for this variability are unknown.
Malena Beecken +8 more
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Cuprizone feeding induces swollen astrocyte endfeet
Pflügers Archiv - European Journal of Physiology, 2022 AbstractThe cuprizone model is a widely used model to study the pathogenesis of multiple sclerosis (MS). Due to the selective loss of mature oligodendrocytes and myelin, it is mainly being used to study demyelination and the mechanisms of remyelination, as well as the efficiency of compounds or therapeutics aiming at remyelination.
Petra Fallier-Becker +2 more
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NeuroImage, 2022 Disruptions in oxidative metabolism may occur in multiple sclerosis and other demyelinating neurological diseases. The impact of demyelination on metabolic rate is also not understood.
Mada Hashem +4 more
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Thymic Atrophy and Apoptosis of CD4+CD8+ Thymocytes in the Cuprizone Model of Multiple Sclerosis. [PDF]
PLoS ONE, 2015 Previous studies on the degenerative animal model of multiple sclerosis suggested that the copper-chelator cuprizone might directly suppress T-cell functions.
Izabella Solti +10 more
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