Results 21 to 30 of about 9,893 (241)

The Cuprizone Model: Dos and Do Nots [PDF]

Cells, 2020
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. Various pre-clinical models with different specific features of the disease are available to study MS pathogenesis and to develop new therapeutic options.
Jiangshan Zhan, Teresa Mann, Sarah Joost, Newshan Behrangi, Marcus Frank, Markus Kipp   +5 more
openaire   +3 more sources

AAV-Based Intracerebral Administration of BDNF Promotes Myelin Repair and Cognitive Improvement After Cuprizone-Induced Demyelination. [PDF]

Glia
Main Points AAV‐BDNF improves cognitive performance after cuprizone‐induced demyelination. BDNF promotes OPC maturation and enhances remyelination in the corpus callosum. Mitochondrial integrity is preserved through reduced swelling and improved morphology.
El Ouaamari Y, Ricciardi L, van der Heijden S, Peter A, De Waele J, Van den Bos J, Van Dam D, Calus E, Kuhn S, Marei W, Dombrowski Y, Verhoye M, Ponsaerts P, Wens I, Cools N.   +14 more
europepmc   +2 more sources

Visual Evoked Potentials to Monitor Myelin Cuprizone-Induced Functional Changes

Frontiers in Neuroscience, 2022
The visual system is one of the most accessible routes to study the central nervous system under pathological conditions, such as in multiple sclerosis (MS).
Silvia Marenna, Su-Chun Huang, Gloria Dalla Costa, Gloria Dalla Costa, Raffaele d’Isa, Valerio Castoldi, Elena Rossi, Giancarlo Comi, Giancarlo Comi, Letizia Leocani, Letizia Leocani   +10 more
doaj   +1 more source

Imaging Cuprizone-Induced Mitochondrial Dysfunction [PDF]

, 2020
AbstractCuprizone is a copper chelator that induces mitochondrial dysfunction in myelin-producing oligodendrocytes and hepatic cells. Inhibition of oxidative phosphorylation has been proposed as a potential mechanism, but the exact relationship between shape changes and metabolic alterations is not well-understood.
Lucille A. Ray, Gardenia Pacheco, Alexandra Taraboletti, Michael C. Konopka, Leah P. Shriver   +4 more
openaire   +1 more source

Sex Differences in the Behavioural Aspects of the Cuprizone-Induced Demyelination Model in Mice

Brain Sciences, 2022
Multiple sclerosis is an autoimmune disease characterised by demyelination in the central nervous system. The cuprizone-induced demyelination model is often used in mice to test novel treatments for multiple sclerosis.
Kelly F. Paton, Sheein Hong, Andrew Biggerstaff, Bronwyn M. Kivell   +3 more
doaj   +1 more source

Increased blood-brain barrier hyperpermeability coincides with mast cell activation early under cuprizone administration.

PLoS ONE, 2020
The cuprizone induced animal model of demyelination is characterized by demyelination in many regions of the brain with high levels of demyelination in the corpus callosum as well as changes in neuronal function by 4-6 weeks of exposure.
John Shelestak, Naveen Singhal, Lana Frankle, Riely Tomor, Sarah Sternbach, Jennifer McDonough, Ernest Freeman, Robert Clements   +7 more
doaj   +1 more source

Cuprizone Affects Hypothermia-Induced Neuroprotection and Enhanced Neuroblast Differentiation in the Gerbil Hippocampus after Ischemia

Cells, 2020
In the present study, we investigated the effects of cuprizone on cell death, glial activation, and neuronal plasticity induced by hypothermia after ischemia in gerbils. Food was supplemented with cuprizone at 0.2% ad libitum for eight weeks.
Woosuk Kim, Kyu Ri Hahn, Hyo Young Jung, Hyun Jung Kwon, Sung Min Nam, Tae Hyeong Kim, Jong Whi Kim, Dae Young Yoo, Dae Won Kim, Jung Hoon Choi, Yeo Sung Yoon, In Koo Hwang   +11 more
doaj   +1 more source

Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination

Molecular Neurodegeneration, 2022
Background The dietary consumption of cuprizone – a copper chelator – has long been known to induce demyelination of specific brain structures and is widely used as model of multiple sclerosis.
Martin Zirngibl, Peggy Assinck, Anastasia Sizov, Andrew V. Caprariello, Jason R. Plemel   +4 more
doaj   +1 more source

Exogenous Leukemia Inhibitory Factor Stimulates Oligodendrocyte Progenitor Cell Proliferation and Enhances Hippocampal Remyelination [PDF]

, 2012
New CNS neurons and glia are generated throughout adulthood from endogenous neural stem and progenitor cells. These progenitors can respond to injury, but their ability to proliferate, migrate, differentiate, and survive is usually insufficient to ...
Deverman, Benjamin E., Patterson, Paul H.   +1 more
core   +1 more source

Behavioral and neurobiological changes in C57BL/6 mouse exposed to cuprizone: effects of antipsychotics

Frontiers in Behavioral Neuroscience, 2010
Recent human studies suggest a role for altered oligodendrocytes in the pathophysiology of schizophrenia. Our recent animal study has reported some schizophrenia-like behaviors in mice exposed to cuprizone (Xu et al., 2009), a copper chelator that has ...
Haiyun Xu, Hong Yang, Bryan McConomy, Ronald A Browning, Xin-Min Li   +4 more
doaj   +1 more source