Acutely damaged axons are remyelinated in multiple sclerosis and experimental models of demyelination [PDF]
, 2017 Remyelination is in the center of new therapies for the treatment of multiple sclerosis to resolve and improve disease symptoms and protect axons from further damage.
Bramlett +38 more
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Mechanisms involved in the remyelinating effect of sildenafil [PDF]
, 2018 Remyelination occurs in demyelinated lesions in multiple sclerosis (MS) and pharmacological treatments that enhance this process will critically impact the long term functional outcome in the disease.
Díaz-Lucena, Daniela +5 more
core +1 more source
Galectin-3-mediated glial crosstalk drives oligodendrocyte differentiation and (Re)myelination [PDF]
, 2018 Galectin-3 (Gal-3) is the only chimeric protein in the galectin family. Gal-3 structure comprises unusual tandem repeats of proline and glycine-rich short stretches bound to a carbohydrate-recognition domain (CRD).
Pasquini, Laura Andrea, Thomas, Laura
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Frontiers in Molecular Neuroscience, 2021 Cannabidiol, a compound of Cannabis sativa, has been proposed as an alternative treatment of schizophrenia. Preclinical and clinical data have suggested that cannabidiol shares more similarity with atypical antipsychotics than typical, both of which are ...
Ana Caroline Brambilla Falvella +12 more
doaj +1 more source
Adult mesenchymal stem cell therapy for myelin repair in Multiple Sclerosis. [PDF]
, 2012 Multiple sclerosis (MS) is a demyelinating immune-mediated disease of the central nervous system (CNS). It is the most frequent neurological disease in young adults and affects over 2 million people worldwide.
Aigner, Ludwig, Rivera, Francisco J
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Histological correlation of diffusional kurtosis and white matter modeling metrics in cuprizone-induced corpus callosum demyelination [PDF]
, 2014 The cuprizone mouse model is well established for studying the processes of both demyelination and remyelination in the corpus callosum, and it has been utilized together with diffusion tensor imaging (DTI) to investigate myelin and axonal pathology ...
Barazany +64 more
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Myelin copper and the cuprizone model of schizophrenia [PDF]
Frontiers in Bioscience, 2011 In recent years increasing evidence is pointing toward white matter abnormalities in schizophrenia and other psychiatric disorders. The present paper will provide an overview over the role of myelin in cognition and brain function, and its potential involvement in brain disorders.
Nicole R, Herring, Christine, Konradi
openaire +2 more sources
Progesterone alleviates neural behavioral deficits and demyelination with reduced degeneration of oligodendroglial cells in cuprizone-induced mice. [PDF]
PLoS ONE, 2013 Demyelination occurs widely in neurodegenerative diseases. Progesterone has neuroprotective effects, is known to reduce the clinical scores and the inflammatory response.
Jian-Ning Ye +8 more
doaj +1 more source
Statin therapy inhibits remyelination in the central nervous system [PDF]
, 2009 Remyelination of lesions in the central nervous system contributes to neural repair following clinical relapses in multiple sclerosis. Remyelination is initiated by recruitment and differentiation of oligodendrocyte progenitor cells (OPCs) into ...
Baron +48 more
core +2 more sources
Ferroptosis Mediates Cuprizone-Induced Loss of Oligodendrocytes and Demyelination [PDF]
The Journal of Neuroscience, 2020 Multiple sclerosis (MS) is a chronic demyelinating disease of the CNS. Cuprizone (CZ), a copper chelator, is widely used to study demyelination and remyelination in the CNS, in the context of MS. However, the mechanisms underlying oligodendrocyte (OL) cell loss and demyelination are not known.
Priya Jhelum +6 more
openaire +2 more sources