Results 41 to 50 of about 9,893 (241)
Brain and Behavior, 2019 Introduction The aim of this study was to investigate the effects of cuprizone on adult hippocampal neurogenesis in naïve mice. Additionally, we also studied how melatonin affects the neuronal degeneration induced by cuprizone.
Woosuk Kim +11 more
doaj +1 more source
The effect of omega-3 fatty acids on central nervous system remyelination in fat-1 mice [PDF]
, 2017 Background There is a large body of experimental evidence suggesting that omega-3 (n-3) polyunsaturated fatty acids (PUFAs) are capable of modulating immune function.
Paul, Friedemann +3 more
core +4 more sources
Astrocytes: Lessons Learned from the Cuprizone Model
International Journal of Molecular Sciences, 2023 A diverse array of neurological and psychiatric disorders, including multiple sclerosis, Alzheimer’s disease, and schizophrenia, exhibit distinct myelin abnormalities at both the molecular and histological levels. These aberrations are closely linked to dysfunction of oligodendrocytes and alterations in myelin structure, which may be pivotal factors ...
openaire +2 more sources
Age Influences Microglial Activation After Cuprizone-Induced Demyelination [PDF]
Frontiers in Aging Neuroscience, 2018 Multiple sclerosis (MS) is a chronic inflammatory CNS disease, which causes demyelinated lesions and damages white and gray matter regions. Aging is a significant factor in the progression of MS, and microglia, the immune cells of the CNS tissue, play an important role in all disease stages. During aging, microglia are functionally altered.
Barbara Klein +13 more
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Induced Stem Cells as a Novel Multiple Sclerosis Therapy. [PDF]
, 2016 Stem cell replacement is providing hope for many degenerative diseases that lack effective therapeutic methods including multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system. Transplantation of neural stem cells or
Guan, Yang-Tai +3 more
core +2 more sources
ASN Neuro, 2020 The levels of brain-derived neurotrophic factor (BDNF) in the corpus callosum have previously been shown to have a critical impact on oligodendrocyte (OLG) lineage cells during cuprizone-elicited demyelination. In particular, BDNF+/– mice exhibit greater
Yangyang Huang +6 more
doaj +1 more source
AxonDeepSeg: automatic axon and myelin segmentation from microscopy data using convolutional neural networks [PDF]
, 2017 Segmentation of axon and myelin from microscopy images of the nervous system provides useful quantitative information about the tissue microstructure, such as axon density and myelin thickness. This could be used for instance to document cell morphometry
Antonsanti, Pierre-Louis +5 more
core +3 more sources
Cognitive disturbances in the cuprizone model of multiple sclerosis [PDF]
Genes, Brain and Behavior, 2020 AbstractCognitive problems frequently accompany neurological manifestations of multiple sclerosis (MS). However, during screening of preclinical candidates, assessments of behaviour in mouse models of MS typically focus on locomotor activity. In the present study, we analysed cognitive behaviour of 9 to 10‐week‐old female C57Bl/6J mice orally ...
Maksym V. Kopanitsa +13 more
openaire +4 more sources
Laquinimod ameliorates secondary brain inflammation
Neurobiology of Disease, 2020 Accumulating evidence suggests that a degenerative processes within the brain can trigger the formation of new, focal inflammatory lesions in Multiple Sclerosis (MS).
Julia Nedelcu +9 more
doaj +1 more source
White matter integrity as a predictor of response to treatment in first episode psychosis [PDF]
, 2013 The integrity of brain white matter connections is central to a patient's ability to respond to pharmacological interventions. This study tested this hypothesis using a specific measure of white matter integrity, and examining its relationship to ...
Bonaccorso, S +14 more
core +2 more sources