Results 51 to 60 of about 9,893 (241)

Cuprizone toxicity and Garcinia kola biflavonoid complex activity on hippocampal morphology and neurobehaviour

Heliyon, 2019
Cuprizone-induced neurotoxicity has been employed to study the biology of remyelination in experimental models of multiple sclerosis. This study was aimed at determining the role of kolaviron, a biflavonoid from Garcinia kola, in mitigating the damaging ...
G.O. Omotoso, O.J. Olajide, I.T. Gbadamosi, J.O. Adebayo, B.U. Enaibe, O.B. Akinola, B.V. Owoyele   +6 more
doaj   +1 more source

Galectin-1 in myelin repair [PDF]

, 2016
Galectin-1 (Gal-1) is a member of a highly conserved family of animal lectins which binds to the common disaccharide [Galβ(1-4)-GlcNAc] on both N- and O-glycans decorating cell surface glycoconjugates.
Pasquini, Laura Andrea, Rinaldi, Mariana, Thomas, Laura   +2 more
core   +2 more sources

Oligodendrogenesis from neural stem cells: Perspectives for remyelinating strategies [PDF]

, 2013
Mobilization of remyelinating cells spontaneously occurs in the adult brain. These cellular resources are specially active after demyelinating episodes in early phases of multiple sclerosis (MS).
Bernardino, Liliana, Grade, Sofia, Malva, João O.   +2 more
core   +1 more source

Spatio-Temporal Patterns of Demyelination and Remyelination in the Cuprizone Mouse Model. [PDF]

PLoS ONE, 2016
Cuprizone administration in mice provides a reproducible model of demyelination and spontaneous remyelination, and has been useful in understanding important aspects of human disease, including multiple sclerosis.
Ian Tagge, Audrey O'Connor, Priya Chaudhary, Jim Pollaro, Yosef Berlow, Megan Chalupsky, Dennis Bourdette, Randy Woltjer, Mac Johnson, William Rooney   +9 more
doaj   +1 more source

Thalamocortical-auditory network alterations following cuprizone‐induced demyelination [PDF]

Journal of Neuroinflammation, 2016
Demyelination and remyelination are common pathological processes in many neurological disorders, including multiple sclerosis (MS). Clinical evidence suggests extensive involvement of the thalamocortical (TC) system in patients suffering from MS.Using murine brain slices of the primary auditory cortex, we investigated the functional consequences of ...
Ghaffarian, Nikoo, Mesgari, Masoud, Cerina, Manuela, Göbel, Kerstin, Budde, Thomas, Speckmann, Erwin-Josef, Meuth, Sven G., Gorji, Ali   +7 more
openaire   +2 more sources

Cuprizone short-term exposure: Astrocytic IL-6 activation and behavioral changes relevant to psychosis

Neurobiology of Disease, 2013
A growing body of evidence suggests the involvement of inflammatory processes in the pathophysiology of schizophrenia. Four- to 8-week exposure to cuprizone, a copper chelator, causes robust demyelination and has been used to build a model for multiple ...
Tomoaki Tezuka, Makoto Tamura, Mari A. Kondo, Masaki Sakaue, Kinya Okada, Kana Takemoto, Atsushi Fukunari, Keiko Miwa, Hiromitsu Ohzeki, Shin-ichi Kano, Hiroshi Yasumatsu, Akira Sawa, Yasushi Kajii   +12 more
doaj   +1 more source

Mesenchymal stromal-cell transplants induce oligodendrocyte progenitor migration and remyelination in a chronic demyelination model. [PDF]

, 2013
Demyelinating disorders such as leukodystrophies and multiple sclerosis are neurodegenerative diseases characterized by the progressive loss of myelin that may lead toward a chronic demyelination of the brain¿s white matter, impairing normal axonal ...
A Nishiyama, A Nishiyama, A Nishiyama, A Uccelli, A Williams, AI Caplan, B Menn, BA Barres, BA Barres, C Steffenhagen, D Pastor, DL Sellers, DM Chari, DM Chari, DM Chari, F Jiang, FJ Rivera, FJ Rivera, FJ Rivera, FJ Sim, G Wolswijk, I Del Valle, J Jones, J Zhang, J Zhang, JG Boyd, JG Nutt, JM Levine, KA Nave, L Steinman, M Beck, M Cristofanilli, M Eriksdotter-Jönhagen, O Aktas, P Ye, RC Armstrong, RD McKinnon, RJ Franklin, S Kumar, T Kuhlmann, W Kohler   +40 more
core   +2 more sources

Single-cell microglial transcriptomics during demyelination defines a microglial state required for lytic carcass clearance

Molecular Neurodegeneration, 2022
Background Microglia regulate the response to injury and disease in the brain and spinal cord. In white matter diseases microglia may cause demyelination. However, how microglia respond and regulate demyelination is not fully understood.
Sameera Zia, Brady P. Hammond, Martin Zirngibl, Anastasia Sizov, Charbel S. Baaklini, Sharmistha P. Panda, Madelene F. S. Ho, Kelly V. Lee, Apurba Mainali, Mena K. Burr, Sioned Williams, Andrew V. Caprariello, Christopher Power, Thomas Simmen, Bradley J. Kerr, Jason R. Plemel   +15 more
doaj   +1 more source

The Effect of Melatonin on Behavioral, Molecular, and Histopathological Changes in Cuprizone Model of Demyelination [PDF]

, 2016
Multiple sclerosis (MS) is an autoimmune, demyelinating disease of the central nervous system. The protective effects of melatonin (MLT) on various neurodegenerative diseases, including MS, have been suggested.
Ghadiri, T., Ghaemi, A., Gorji, A., Khodagholi, F., Noorbakhsh, F., Sharifzadeh, M., Vakilzadeh, G.   +6 more
core  

Effects of Tributyltin Chloride on Human Neuronal Differentiation and Mice Brain Development

Environmental Toxicology, EarlyView.
ABSTRACT According to the developmental origins of health and disease hypothesis, perinatal exposure to an environmental toxicant during the development of the nervous system could cause a permanent cellular modification that may promote the appearance of neurodegenerative diseases at an older age.
Ester López‐Gallardo, Patricia Meade, Irene Jiménez‐Salvador, Carmen Hernández‐Ainsa, Eldris Iglesias, Alba Pesini, Nuria Garrido‐Pérez, Sonia Emperador, David Pacheu‐Grau, Pilar Bayona‐Bafaluy, Eduardo Ruiz‐Pesini   +10 more
wiley   +1 more source