Results 61 to 70 of about 9,893 (241)

Deep gray matter demyelination detected by magnetization transfer ratio in the cuprizone model. [PDF]

PLoS ONE, 2013
In multiple sclerosis (MS), the correlation between lesion load on conventional magnetic resonance imaging (MRI) and clinical disability is weak. This clinico-radiological paradox might partly be due to the low sensitivity of conventional MRI to detect ...
Sveinung Fjær, Lars Bø, Arvid Lundervold, Kjell-Morten Myhr, Tina Pavlin, Oivind Torkildsen, Stig Wergeland   +6 more
doaj   +1 more source

Inflammasomes in neuroinflammatory and neurodegenerative diseases [PDF]

, 2019
Neuroinflammation and neurodegeneration often result from the aberrant deposition of aggregated host proteins, including amyloid-beta, alpha-synuclein, and prions, that can activate inflammasomes.
Lamkanfi, Mohamed, Srinivasan, Sahana, van Loo, Geert, Voet, Sofie   +3 more
core   +2 more sources

Klotho pathways, myelination disorders, neurodegenerative diseases, and epigenetic drugs [PDF]

, 2020
In this review we outline a rationale for identifying neuroprotectants aimed at inducing endogenous Klotho activity and expression, which is epigenetic action, by definition. Such an approach should promote remyelination and/or stimulate myelin repair by
Chen, Xiaohong, Faller, Douglas V., Glavas, Ioannis P., Harpp, David N., Kanara, Iphigenia, Kodukula, Krishna, Mavrakis, Anastasios N., Moos, Walter H., Pernokas, Julie, Pernokas, Mark, Pinkert, Carl A., Powers, Whitney R., Sampani, Konstantina, Steliou, Kosta, Vavvas, Demetrios G., Zamboni, Robert J.   +15 more
core   +1 more source

Titration of cuprizone induces reliable demyelination

Brain Research
Multiple Sclerosis (MS) is a chronic inflammatory disease of the central nervous system. Cuprizone-induced demyelination, wherein mice are fed a diet containing the copper chelator cuprizone, is a well-established model that replicates key features of demyelination and remyelination. However, the dose-response relationship of cuprizone is complex; high
Nicole, Wigger, Johann, Krüger, Elise, Vankriekelsvenne, Markus, Kipp   +3 more
openaire   +2 more sources

Cerebellar Cortical Demyelination in the Murine Cuprizone Model

Brain Pathology, 2010
AbstractIn multiple sclerosis, demyelination occurs beside the white‐matter structures and in the cerebral and cerebellar cortex. We have previously shown that, in the cuprizone model, demyelination is present not only in the corpus callosum but also in the cerebral cortex.
Thomas, Skripuletz, Jens-Heiko, Bussmann, Viktoria, Gudi, Paraskevi N, Koutsoudaki, Refik, Pul, Darius, Moharregh-Khiabani, Maren, Lindner, Martin, Stangel   +7 more
openaire   +3 more sources

The glia‐immune network: Astrocytes and oligodendrocytes as microglial co‐ordinators in health and disease

The Journal of Physiology, EarlyView.
Abstract figure legend The glia‐immune network involves the communication(s) of glia via immune signalling pathways. In neuro‐homeostasis these pathways have been shown to modulate key processes such as synaptic pruning and myelination. The dynamics of these processes is critical to CNS function.
Verity F. T. Mitchener, Millie J. Thackray, I. Lorena Arancibia‐Cárcamo   +2 more
wiley   +1 more source

Dietary Supplementation With Acer truncatum Oil Promotes Remyelination in a Mouse Model of Multiple Sclerosis

Frontiers in Neuroscience, 2022
BackgroundMultiple sclerosis is a chronic demyelinating disease of uncertain etiology. Traditional treatment methods produce more adverse effects. Epidemiological and clinical treatment findings showed that unknown environmental factors contribute to the
Yuhuan Xue, Xiaoyan Zhu, Wenyong Yan, Zhihan Zhang, Enhui Cui, Yongji Wu, Cixia Li, Jiarong Pan, Qijiang Yan, Xuejun Chai, Shanting Zhao   +10 more
doaj   +1 more source

Demyelination and axonal preservation in a transgenic mouse model of Pelizaeus-Merzbacher disease [PDF]

, 2010
It is widely thought that demyelination contributes to the degeneration of axons and, in combination with acute inflammatory injury, is responsible for progressive axonal loss and persistent clinical disability in inflammatory demyelinating disease.
Angus M. Brown, Fredrik I. Gruenenfelder, Ian R. Griffiths, Julia M. Edgar, Klaus‐Armin Nave, Laura Pratola, Mailis C. McCulloch, Paul Montague, Sebastian Thilemann, Siegal S, Williams MA   +10 more
core   +2 more sources

In toxic demyelination oligodendroglial cell death occurs early and is FAS independent

Neurobiology of Disease, 2010
Oligodendroglial cell death is a frequent phenomenon of many neurological diseases, e.g. in demyelinating diseases such as multiple sclerosis (MS). The underlying mechanisms are largely unknown.
Amke Hesse, Michael Wagner, Jasmin Held, Wolfgang Brück, Gabriela Salinas-Riester, Zhenyue Hao, Ari Waisman, Tanja Kuhlmann   +7 more
doaj   +1 more source

TREM2 sustains microglial expansion during aging and response to demyelination [PDF]

, 2015
Microglia contribute to development, homeostasis, and immunity of the CNS. Like other tissue-resident macrophage populations, microglia express the surface receptor triggering receptor expressed on myeloid cells 2 (TREM2), which binds polyanions, such as
Colonna, Marco, Fontana, Elena, Gilfillan, Susan, Poliani, Pietro Luigi, Robinette, Michelle L, Wang, Yaming, Yamanishi, Yoshinori   +6 more
core   +1 more source