Results 81 to 90 of about 9,893 (241)
Medicine Bulletin, Volume 1, Issue 2, Page 104-120, December 2025.ABSTRACT In multiple sclerosis (MS), demyelination is often accompanied by severe motor and cognitive disability. Remyelination is the process of regenerating new myelin sheath on impaired axons, which is typically carried out by oligodendrocyte precursor cells (OPCs).
Zixin Gao +6 more
wiley +1 more source
Brain and Behavior, Volume 15, Issue 11, November 2025.The glucagon‐like peptide‐1 receptor agonist (GLP‐1RA) liraglutide alleviates disease severity of experimental autoimmune encephalomyelitis (EAE) mice by reducing splenic T helper 1 cell expansion. These findings suggest GLP‐1RA might exert disease‐modifying effects in the EAE model through peripheral immunomodulatory effects of splenic T helper cells.
Shuang Song +5 more
wiley +1 more source
Brain and BehaviorObjective To investigate whether nicotinamide adenine dinucleotide (NAD+) supplementation can improve behavioral changes in a cuprizone‐intoxicated mouse model.
Shuang Song +6 more
doaj +1 more source
Cells, 2019 Brain volume measurement is one of the most frequently used biomarkers to establish neuroprotective effects during pre-clinical multiple sclerosis (MS) studies.
Tanja Hochstrasser +9 more
doaj +1 more source
NeuroImage, 2023 : Background: To investigate the association of ihMT (inhom signals with the demyelination and remyelination phases of the acute cuprizone mouse model in comparison with histology, and to assess the extent of tissue damage and repair from MRI data ...
Andreea Hertanu +12 more
doaj +1 more source
Effects of aerobic exercise on demyelination and brain morphology in the cuprizone rat model of multiple sclerosis [PDF]
, 2023 Maryam Abbasi +3 more
openalex +1 more source
Galanin is an autocrine myelin and oligodendrocyte trophic signal induced by leukemia inhibitory factor [PDF]
, 2015 In order to further investigate the molecular mechanisms that regulate oligodendrocyte (OC) survival, we utilized microarrays to characterize changes in OC gene expression after exposure to the cytokines neurotrophin3, insulin, or leukemia inhibitory ...
Alonzi +29 more
core +2 more sources
17β-Estradiol Enhances the Efficacy of Adipose-Derived Mesenchymal Stem Cells on Remyelination in Mouse Model of Multiple Sclerosis [PDF]
Acta Medica Iranica, 2012 Previous studies have demonstrated the potential of monotherapy with either mesenchymal stem cells (MSCs) or estrogen in autoimmune and cuprizone models of multiple sclerosis (MS).
Iraj Ragerdi Kashani +7 more
doaj +1 more source
Effects of insulin-like growth factor 1 on pathologic process in the cuprizone model of multiple sclerosis [PDF]
, 2017 The study aimed to evaluate the effect of insulin-like growth factor 1 (IGF-1) on the cuprizone-induced murine model of demyelination and accompanying astrogliosis. Demyelination was induced in 14 adult male mice by 0.3% cuprizone in drinking water. Five
Федоришин, Д. А.
core
Development of a Human Preclinical Platform for the Identification of Neuroprotective Compounds
European Journal of Neuroscience, Volume 62, Issue 10, November 2025.Neuroprotection screening on neurons and OLs in oxidative stress and axonal damage assays. Analysis of neurite outgrowth, apoptosis, ROS, OL differentiation and proteomics. Cuprizone model assessed effects on neurodegeneration, inflammation and pro‐myelination.
Raquel Guerrero González +8 more
wiley +1 more source