HMGB1/NF-κB Axis, IL-8, and Cuproptosis Contribute to Cisplatin-Induced Testicular Injury: Protective Potential Effect of Thymol. [PDF]
BiomoleculesAlkharashi L +10 more
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Identification and validation of prognostic markers for cuproptosis-related macrophage polarization genes in hepatocellular carcinoma. [PDF]
Discov OncolDeng X, Cao J, Liang Y, Lyu B, Tong L.
europepmc +1 more source
Integrated bioinformatics analysis identifies cuproptosis and ferroptosis gene signatures via subgroup clustering: Prognostic and therapeutic implications in breast cancer. [PDF]
Biochem Biophys RepWei Y, Wei X, Zhao W.
europepmc +1 more source
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Cuproptosis and cuproptosis-related genes: Emerging potential therapeutic targets in breast cancer
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2023Breast cancer is one of the most common malignant tumors in women worldwide, and thus, it is important to enhance its treatment efficacy [1]. Copper has emerged as a critical trace element that affects various intracellular signaling pathways, gene expression, and biological metabolic processes [2], thereby playing a crucial role in the pathogenesis of
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Copper homeostasis and cuproptosis in mitochondria
Life Sciences, 2023Mitochondria serve as sites for energy production and are essential for regulating various forms of cell death induced by metal metabolism, targeted anticancer drugs, radiotherapy and immunotherapy. Cuproptosis is an autonomous form of cell death that depends on copper (Cu) and mitochondrial metabolism.
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Cuproptosis and Cuproptosis‐Based Synergistic Therapy for Cancer Treatment
ChemMedChemAbstractCopper, as an essential trace nutrient for human, plays a crucial role in numerous cellular activities, and is vital for maintaining homeostasis in organisms. Deviations from normal intracellular copper concentration range can disrupt the cellular homeostasis and lead to cell death.
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Cuproptosis: Harnessing Transition Metal for Cancer Therapy
ACS Nano, 2023Transition metal elements, such as copper, play diverse and pivotal roles in oncology. They act as constituents of metalloenzymes involved in cellular metabolism, function as signaling molecules to regulate the proliferation and metastasis of tumors, and are integral components of metal-based anticancer drugs.
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Cuproptosis to Cuproptosis‐Like: Therapeutic Strategies for Bacterial Infection
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Ferroptosis, Pyroptosis, and Cuproptosis in Alzheimer’s Disease
ACS Chemical Neuroscience, 2023Alzheimer's disease (AD), the most common type of dementia, is a neurodegenerative disorder characterized by progressive cognitive dysfunction. Epidemiological investigation has demonstrated that, after cardiovascular and cerebrovascular diseases, tumors, and other causes, AD has become a major health issue affecting elderly individuals, with its ...
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