Results 201 to 210 of about 7,425 (214)

Protein lipoylation: mitochondria, cuproptosis, and beyond

Trends in Biochemical Sciences
Protein lipoylation, a crucial post-translational modification (PTM), plays a pivotal role in mitochondrial function and emerges as a key player in cell death through cuproptosis. This novel copper-driven cell death pathway is activated by excessive copper ions binding to lipoylated mitochondrial proteins, disrupting energy production and causing ...
Cheng-Han Lin, Yeh Chin, Ming Zhou, Robert W. Sobol, Mien-Chie Hung, Ming Tan   +5 more
openaire   +2 more sources

Targeting cuproplasia and cuproptosis in cancer

Nature Reviews Clinical Oncology
Copper, an essential trace element that exists in oxidized and reduced forms, has pivotal roles in a variety of biological processes, including redox chemistry, enzymatic reactions, mitochondrial respiration, iron metabolism, autophagy and immune modulation; maintaining copper homeostasis is crucial as both its deficiency and its excess are deleterious.
Daolin Tang, Guido Kroemer, Rui Kang
openaire   +2 more sources

Cuproptosis: Mechanism and Application in Lymphoma

Current Cancer Drug Targets
The cell death field has profited from the increasing attention of the scientific community and has been shown to lie at the very basis of cancer initiation and progression. Cuproptosis is a recently proposed method of cell death in 2022, and it is different from any previously reported method.
Yubo, Wang, Fengyue, Yin, Quanyi, Jin, Chen, Liu, Zhongquan, Qi, Dengyue, Chen, Yiming, Luo   +6 more
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A cuproptosis nanocapsule for cancer radiotherapy

Nature Nanotechnology
Residual tumours that persist after radiotherapy often develop acquired radiation resistance, increasing the risk of recurrence and metastasis while providing obstacles to re-irradiation. Using samples from patients and experimental mice, we discovered that FDX1 and LIAS, key regulators of cuproptosis, were up-regulated in residual tumours following ...
You Liao, Dongmei Wang, Chenglu Gu, Xue Wang, Shuang Zhu, Ziye Zheng, Fuquan Zhang, Junfang Yan, Zhanjun Gu   +8 more
openaire   +2 more sources

Sepsis induced cardiotoxicity by promoting cardiomyocyte cuproptosis

Biochemical and Biophysical Research Communications
Currently, sepsis induced cardiotoxicity is among the major causes of sepsis-related death. The specific molecular mechanisms of sepsis induced cardiotoxicity are currently unknown. Therefore, the purpose of this paper is to identify the key molecule mechanisms for sepsis induced cardiotoxicity.Original data of sepsis induced cardiotoxicity was derived
Jingru, Yan, Zhangyi, Li, Yilan, Li, Yao, Zhang   +3 more
openaire   +2 more sources

Cuproptosis and physical training.

Clinical hemorheology and microcirculation
Copper is an essential element in the human body, involved in many physiological and metabolic functions, including coagulation, oxidative metabolism, and hormone production. The maintenance of copper homeostasis within cells is a complex procedure that is intrinsically controlled by a multitude of intricate mechanisms.
Negin, Kordi, Ali, Saydi, Maliheh, Azimi, Farivar Haji, Mazdarani, Keivan, Gadruni, Friedrich, Jung, Sajad, Karami   +6 more
openaire   +1 more source

The mechanism of cuproptosis in Parkinson’s disease

Ageing Research Reviews
Parkinson's disease (PD) is a neurodegenerative disease with an increased morbidity. The pathogenesis PD has not been fully elucidated, and whatever mechanism is involved, it ultimately leads to dopamine (DA) neuronal apoptosis. Cuproptosis is a novel form of cell death.
Min Huang, Yong Zhang, Xuehong Liu
openaire   +2 more sources

Cuproptosis: A Copper‐Mediated Programmed Cell Death

Chemistry – An Asian Journal
AbstractIt has been found that various heavy metals can initiate different types of regulated cell deaths. Among these metals, copper, an essential trace micronutrient that plays a major role in a lot of physiological processes, also can initiate cell death. It can act as a constituent of metalloenzymes, and can act as a mediator for signaling pathways
Radhika Meena, Suman Sekhar Sahoo, Andria Sunil, Debasish Manna   +3 more
openaire   +2 more sources

Cuproptosis: copper-induced regulated cell death

Science China Life Sciences, 2022
Wen-Jun, Duan, Rong-Rong, He
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Environmental copper exposure, placental cuproptosis, and miscarriage

Environmental Pollution
Copper pollution has become global environmental concern. Widespread Cu pollution results in excessive Cu exposure in human. Epidemiological studies and animal experiments revealed that Cu exposure might have reproductive toxicity. Cuproptosis is a newly reported Cu-dependent and programmed cell death formTsvetkov et al., 2022.
Jingsong Zhao, Zhongyan Xu, Xiaoqing Wang, Shukun Wan, Weina Chen, Wenxin Huang, Manli Wang, Rong Wang, Huidong Zhang   +8 more
openaire   +2 more sources