Results 41 to 50 of about 1,310,929 (245)
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
An evaluation of an inquiry-based computer-assisted learning environment [PDF]
, 1994 This study focused on students' development of inquiry skills in a computerized learning environment. Seven Year-11 classes (n=120) interacted with a computerized database, "Birds of Antarctica," and curriculum materials while the teacher used an inquiry
Fraser, B., Maor, D.
core
Curriculum in the Making: Theory, Practice, and Social Action Curriculum Projects [PDF]
, 2010 This article explores the ways a Social Action Curriculum Project (SACP) framework offered opportunities for students in a graduate level education course to wrestle with the complexity of an ever-evolving school experience.
Schultz, Brian D., Baricovich, Jon E.
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Review and evaluation of the Inquiry to Implementation Project final report 2014 [PDF]
, 2014 The inquiry based professional learning project, Inquiry to Implementation was developed by the Victorian Curriculum and Assessment Authority (VCAA) as a key professional learning resource to support implementation of the Victorian Early Years Learning ...
Marilyn Fleer, Linda Harrison, Iris Duhn
core
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Journal of Curriculum Studies, 2016 本研究主要提出一套整合性的課程設計模式，知識結構─提問─對話模式，結合知識結構、同儕提問與交互對話等方式以探究其對師資生課程學習之影響。本研究針對20位修讀「課程發展與設計」的師資生進行課程學習探究，主要以課程發展與設計知識測驗、課程發展與設計課程學習問卷，以及課程發展與設計課程作業作為研究工具，所獲致的結果如下：一、就課程概念而言，師資生的課程知識測驗與課程學習問卷呈現教學後優於教學前的現象；二、就課程提問而言，師資生呈現提問熟悉度的提升以及提問的效果；三、就課程對話而言 ...
陳沛嵐 Pei-Lan Chen
doaj +1 more source
Journal of Research in Education Sciences, 2023 108新課綱強調「透過探究與實作達到課程統整的目的」，因此，師資職前教育課程基準要求師資生具備「協同發展跨領域課程教學與評量」及「探究與實作設計與實施」的專業素養。簡言之，即師資生須具備發展「跨學科探究與實作」的「課程教學與評量」之素養。然如何培養師資生這些素養以及成效如何，尚缺實徵研究。近年芬蘭推動「現象為本的學習」或可培養這些素養，研究者據以開發一門「雙實作」的「教育實踐課程」，第一個實作是師資生在大學端親身經歷探究實作的過程，接著進入第二個實作：設計一門「探究入門」微課程，到高中端教學實踐5週 ...
符碧真 Bih-Jen Fwu +1 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source