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Role of CXCL12 and CXCR4 in the pathogenesis of hematological malignancies
Cytokine, 2018The chemokine receptor CXCR4 and its ligand stromal cell-derived factor-1 (SDF-1/CXCL12) are important players in the cross-talk among lymphoma, myeloma and leukemia cells and their microenvironments. In hematological malignancies and solid tumors, the overexpression of CXCR4 on the cell surface has been shown to be responsible for disease progression,
Amnon Peled +4 more
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CXCR4/CXCL12 as a Therapeutic Target
2014The interaction of acute myeloid leukemia (AML) blasts with the bone marrow microenvironment regulates critical processes important in sustaining the malignant clone including self-renewal, cell growth, and proliferation as well as resistance to chemotherapy.
Geoffrey L. Uy, John F. DiPersio
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ความสำคัญและที่มาปัญหาการวิจัย : 14-40% ผู้ป่วยมะเร็งปอดชนิดไม่เล็กระยะลุกลามจะเกิดมะเร็งกระจายไปที่กระดูกและประมาณครึ่งหนึ่งจะเกิดภาวะแทรกซ้อนตามมา (1) ซึ่งมีผลต่อคุณภาพชีวิตและอัตราการรอดชีวิตที่ 2 ปี เท่ากับ 11.3%(2) ถึงแม้ว่าการทำ Bone scan และ FDG-PET จะมีความไวและความจำเพาะที่สูง แต่ก็ยังพบว่ามีผลลบและผลบวกลวงได้ในชนิดมะเร็งที่มีการกัดกร่อนท ...
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CXCL12/CXCR4: An amazing challenge and opportunity in the fight against fibrosis
Ageing Research Reviews, 2023Wangrui Lei, Ran Tang, Yang Yang
exaly
Heparin and CXCL12 Dimerization
Journal of Clinical Oncology, 2005Kadri Altundag +2 more
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Glioblastomas: Role of CXCL12 Chemokine
2010Chemokines are small pro-inflammatory chemoattractant cytokines that bind to specific G-protein-coupled seven-span transmembrane receptors on the plasma membrane of target cells. They are also the major regulators of cell trafficking. Chemokines and their receptors were initially associated with the trafficking of leukocytes during physiological immune
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Neuroprotective actions of the chemokine CXCL12
Chemokines are cellular mediators known for their role in immune/inflammatory responses - traditionally, yet simplistically, associated to neuronal damage. However, recent research has not only provided evidence about the beneficial nature of a controlled immune/inflammatory response in the central nervous system (CNS), but also suggested novel ...Jaclyn Nicolai +2 more
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