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Stem-cell regulation in periodontium formation and regeneration. [PDF]
J Bone Miner MetabNagata M, Nagaoka C, Iwata T.
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Regulatory logic underlying neural crest contributions to the head versus the heart. [PDF]
Proc Natl Acad Sci U S AGandhi S +7 more
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The unique structural and functional features of CXCL12 [PDF]
Cellular and Molecular Immunology, 2017 The CXC chemokine CXCL12 is an important factor in physiological and pathological processes, including embryogenesis, hematopoiesis, angiogenesis and inflammation, because it activates and/or induces migration of hematopoietic progenitor and stem cells, endothelial cells and most leukocytes.
Rik Janssens +2 more
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CXCL12 Signaling in the Tumor Microenvironment
2021Tumor microenvironment (TME) is the local environment of tumor, composed of tumor cells and blood vessels, extracellular matrix (ECM), immune cells, and metabolic and signaling molecules. Chemokines and their receptors play a fundamental role in the crosstalk between tumor cells and TME, regulating tumor-related angiogenesis, specific leukocyte ...
Luigi, Portella +2 more
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CXCL12: Role in neuroinflammation
The International Journal of Biochemistry & Cell Biology, 2012CXCL12, also known as SDF-1 (stromal cell derived factor-1) is a small protein that belongs to the chemokine family, whose members have a crucial role in directing cell migration. CXCL12 has an essential role in neural and vascular development, hematopoiesis and in immunity. It acts through two receptors, CXCR4 and CXCR7.
Timotijević, Gordana S +2 more
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CXCL12 in control of neuroinflammation
Immunologic Research, 2012Inflammation within the central nervous system (CNS) is strictly controlled and if possible prevented. Such a tight control is necessary due to high sensitivity of nervous tissue to mechanical and biochemical consequences of inflammation. Still, neuroinflammation is a typical feature of a chronic, inflammatory, demyelinating disease multiple sclerosis (
Momčilović, Miljana +2 more
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CXCR7 impact on CXCL12 biology and disease
Trends in Molecular Medicine, 2013 It is known that the chemokine receptor CXCR7 (RDC1) can be engaged by both chemokines CXCL12 (SDF-1) and CXCL11 (I-TAC), but the exact expression pattern and function of CXCR7 is controversial. CXCR7 expression seems to be enhanced during pathological inflammation and tumor development, and emerging data suggest this receptor is an attractive ...
Lorena Sánchez-Martín +2 more
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CXCL12-CXCL4 heterodimerization prevents CXCL12-driven breast cancer cell migration
Cellular Signalling, 2020Despite improvements in cancer early detection and treatment, metastatic breast cancer remains deadly. Current therapeutic approaches have very limited efficacy in patients with triple negative breast cancer. Among the many mechanisms associated that contribute to cancer progression, signaling through the CXCL12-CXCR4 is an essential step in cancer ...
Khanh T.P. Nguyen +6 more
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The role of CXCL12 in tumor microenvironment
Gene, 2018The chemokine ligand C-X-C motif chemokine ligand 12 (CXCL12) is a kind of small molecules of cytokines that widely expressed in diversified tissues. Recent evidence suggests that CXCL12 plays an important role in the communication of tumor cells with their surrounding microenvironment.
Wenfang Meng, Shihang Xue, Ye Chen
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