Results 181 to 190 of about 54,272 (286)

Single‐Cell Transcriptomic Analysis Reveals Ferroptosis‐Related Signatures and Tumor Microenvironment Heterogeneity in Epithelial Ovarian Cancer

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACTEpithelial ovarian cancer (EOC) is the deadliest gynecological malignancy. Ferroptosis, an iron‐dependent lipid peroxidation‐associated cell death mode, provides a new target for tumor therapy. Nevertheless, its impact on EOC tumorigenesis is not well defined.
Jie Liu, Jing Li, Bingxin Li, Hui Liang
wiley   +1 more source

Rapid normal fibroblast‐tumor crosstalk promotes cancer‐associated fibroblast‐like activation and attenuates mitomycin C cytotoxicity in bladder cancer

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Normal bladder fibroblasts rapidly engage in bidirectional crosstalk with bladder cancer cells, acquiring cancer‐associated fibroblast‐like activation features while promoting wound closure, epithelial‐mesenchymal transition‐like cadherin remodeling, and reduced mitomycin C‐induced cytotoxicity.
Jinhui Gao, Cindy Xinyu Ji, Ci Ren, John Hines, Eleanor Stride, Richard T. Bryan, Jennifer L. Rohn   +6 more
wiley   +1 more source

Single‐Cell Profiling Reveals Distinct Immune Hallmarks in Untreated Primary Colorectal and Liver Metastasis Cancers

Chronic Diseases and Translational Medicine, Volume 12, Issue 3, Page 197-208, September 2026.
Features the major cell type compositions among colon and liver metastasis. (A) The study design for single‐cell data analysis. (B) The annotated major cell types. Each type was labeled with a special color. (C) Dot plot of canonical marker genes for major cell types. (D) Bar plot of the percentage for each cell type in individuals. (E) Bar plot of the
Zhixun Zhao, Haipeng Chen, Xu Guan, Zheng Jiang, Zheng Liu, Ming Yang, Hengchang Liu, Tianli Chen, Shuangmei Zou, Yibo Gao, Xishan Wang   +10 more
wiley   +1 more source

STAT3 as a Candidate Shared Regulator of the CXCR4/CXCL12 and CXCR5/CXCL13 Homing Axes in Chronic Lymphocytic Leukemia. [PDF]

Int J Mol Sci
Ntsethe A.
europepmc   +1 more source

A Review of Senescence‐Associated Secretory Phenotype‐Mediated Remodeling of the Tumor Microenvironment: Implications for Cancer Progression and Therapy

Cancer Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background Cellular senescence influences cancer progression through irreversible cell‐cycle arrest, immune surveillance, and paracrine signaling mediated by the senescence‐associated secretory phenotype (SASP). SASP comprises inflammatory cytokines, chemokines, growth factors, and matrix‐remodeling enzymes that regulate the tumor ...
Sneha Pallatt, Sibin Nambidi, Antara Banerjee, Surajit Pathak   +3 more
wiley   +1 more source

Exosomal PSMD1 Derived From Dental Pulp Mesenchymal Stem Cells Promotes Microglial M2 Polarization to Alleviate Spinal Cord Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
DPMSCs‐derived exosomal PSMD1 stimulates M2 polarization through the JAK2/STAT3 pathway. DPMSCs‐derived exosomal PSMD1 indirectly acts on NE‐4C cells. DPMSCs‐derived exosomal PSMD1 ameliorates SCI in a mouse model. ABSTRACT Background Exosomes derived from mesenchymal stem cells (MSCs) and their cargo contribute to the protective properties of MSCs in ...
Xiaohui Xing, Yuan Hao, Guanghui Zhang, Xiaoyang Xing, Hongfei Jia, Chenlong Liu, Xin Wang, Tao Li, Xueyuan Li, Yilei Xiao   +9 more
wiley   +1 more source

CXCR4+ circulating tumor cells (CTCs) accumulate in subcutaneous, immune suppressive, CXCL12-loaded-hydrogel. [PDF]

Mater Today Bio
Portella L, Di Febbraro DG, Righelli D, Bertolini G, Guardascione G, Rea G, D'Alterio C, Ieranò C, Santagata S, Trotta AM, Gentili M, Sulsenti R, Luciano A, Palma G, Bruzzese F, Parisi IA, De Luca A, Roz L, Pacelli R, Scala S.   +19 more
europepmc   +1 more source

Advancing Type 1 Diabetes Treatment: 3 PM‐Oriented Innovations in Islet Transplantation and Biomaterial Engineering

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 6, September 2026.
ABSTRACT Type 1 Diabetes (T1D) is an autoimmune disorder marked by the immune‐mediated destruction of pancreatic β‐cells, resulting in insulin deficiency and dysregulated glucose control. Current therapies—such as insulin replacement and artificial pancreas systems—manage symptoms but fail to restore endogenous β‐cell function or halt disease ...
Fatemeh Sabet Sarvestani, Ramin Yaghobi, Mohsen Khosravi Maharlooei, Mehdi Golshan, Mohammad Hossein Karimi   +4 more
wiley   +1 more source

Physical interaction with Ephrin B1 promotes CXCR4 intracellular localization and oncogenic potential. [PDF]

Cell Mol Life Sci
Rabbito A, Otun O, Fumagalli A, Bartolomé AA, Galant S, Séveno M, Counson M, Durroux T, Bechara C, Smit MJ, Granier S, Szpakowska M, Chevigné A, Chaumont-Dubel S, Marin P.   +14 more
europepmc   +1 more source

Novel Noninvasive Broad‐Spectrum Infrared Treatment of Ulcerative Colitis by Modulating T‐Cell Relocation

ENERGY &ENVIRONMENTAL MATERIALS, Volume 9, Issue 5, September 2026.
A novel graphene‐based broad‐spectrum infrared (BSIR) device is developed for the noninvasive treatment of ulcerative colitis (UC). BSIR irradiation effectively alleviates colonic inflammation and accelerates mucosal recovery by inducing the systemic relocation of T lymphocytes to the spleen.
Siyu Chen, Jiangtao Zhao, Bohan Jia, Zhigang Ren, Ranran Sun, Liwen Liu, Ding Zhang, Yanqiu Fu, Jia Yu, Shen Shen, Fujun Miao, Zaimei Huang, Ruixia Guo, Peng Zhang, Zujiang Yu, Guosheng Shao   +15 more
wiley   +1 more source