Results 161 to 170 of about 1,829 (202)

CXCL12: Role in neuroinflammation

The International Journal of Biochemistry & Cell Biology, 2012
CXCL12, also known as SDF-1 (stromal cell derived factor-1) is a small protein that belongs to the chemokine family, whose members have a crucial role in directing cell migration. CXCL12 has an essential role in neural and vascular development, hematopoiesis and in immunity. It acts through two receptors, CXCR4 and CXCR7.
Timotijević, Gordana S, Mostarica-Stojković, Marija B, Miljković, Đorđe   +2 more
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CXCL12 Signaling in the Tumor Microenvironment

2021
Tumor microenvironment (TME) is the local environment of tumor, composed of tumor cells and blood vessels, extracellular matrix (ECM), immune cells, and metabolic and signaling molecules. Chemokines and their receptors play a fundamental role in the crosstalk between tumor cells and TME, regulating tumor-related angiogenesis, specific leukocyte ...
Luigi, Portella, Anna Maria, Bello, Stefania, Scala   +2 more
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CXCL12 in control of neuroinflammation

Immunologic Research, 2012
Inflammation within the central nervous system (CNS) is strictly controlled and if possible prevented. Such a tight control is necessary due to high sensitivity of nervous tissue to mechanical and biochemical consequences of inflammation. Still, neuroinflammation is a typical feature of a chronic, inflammatory, demyelinating disease multiple sclerosis (
Momčilović, Miljana, Mostarica-Stojković, Marija B, Miljković, Đorđe   +2 more
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The CXCR4/CXCL12 axis in endometrial cancer

Clinical & Experimental Metastasis, 2009
Chemokines and their receptors seem to act as important regulators of the metastatic cascade. CXCL12 and its receptor CXCR4 were shown to be involved in human cancer progression. There is increasing evidences suggesting that the expression of CXCR4 in human cancers is correlated with poor patient prognosis and that CXCR4 neutralization can prevent ...
GELMINI, STEFANIA, MANGONI, MONICA, CASTIGLIONE, FRANCESCA, Beltrami C, Pieralli A, Andersson KL, FAMBRINI, MASSIMILIANO, TADDEI, GIAN LUIGI, SERIO, MARIO, ORLANDO, CLAUDIO   +9 more
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The role of CXCL12 in tumor microenvironment

Gene, 2018
The chemokine ligand C-X-C motif chemokine ligand 12 (CXCL12) is a kind of small molecules of cytokines that widely expressed in diversified tissues. Recent evidence suggests that CXCL12 plays an important role in the communication of tumor cells with their surrounding microenvironment.
Wenfang Meng, Shihang Xue, Ye Chen
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Tumors block pain with CXCL12

Science Signaling, 2017
The chemokine CXCL12 released from early stage pancreatic cancer recruits Schwann cells and suppresses pain signaling.
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CXCL12-γ expression is inhibited in neuroinflammation

Brain Research, 2013
CXCL12 plays a protective role in CNS autoimmunity. Expression of CXCL12-γ, which has distinct structural and functional properties than the other isoforms of CXCL12, was determined in spinal cords of rats immunized to develop experimental autoimmune encephalomyelitis (EAE).
Timotijević, Gordana S, Petković, Filip, Blaževski, Jana, Momčilović, Miljana, Mostarica-Stojković, Marija B, Miljković, Đorđe   +5 more
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Nitric oxide inhibits CXCL12 expression in neuroinflammation

Immunology & Cell Biology, 2013
Chemokine CXCL12 (C‐X‐C motif chemokine ligand 12) restricts immune cell invasion of the central nervous system (CNS) and limits neuroinflammation in experimental autoimmune encephalomyelitis (EAE), an animal model of inflammatory and demyelinating disease of the CNS, multiple sclerosis (MS). Nitric oxide (NO), by contrast, predominantly contributes to
Petković, Filip, Blaževski, Jana, Momčilović, Miljana, Mostarica-Stojković, Marija B, Miljković, Đorđe   +4 more
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CXCR7, CXCR4 and CXCL12: An eccentric trio?

Journal of Neuroimmunology, 2008
CXCR7, formerly called RDC1 is a recently deorphanized G-protein coupled receptor which binds with high affinity the inflammatory and homing chemokines CXCL11/ITAC and CXCL12/SDF-1. Despite its phylogenetic relation and ligand binding properties CXCR7 does not mediate typical chemokine receptor responses such as leukocyte trafficking.
Marcus, Thelen, Sylvia, Thelen
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CXCL12/CXCR4 signalling in neuronal cell migration

Current Opinion in Neurobiology, 2008
The chemokine CXCL12 (or SDF-1) and its receptor CXCR4 have originally been described as regulators of cell interactions in the immune system. However, over the past years it has become clear that this receptor/ligand pair is an important component of the machinery that controls cell migration in different regions of the developing nervous system. Here
Tiveron, M.C., Cremer, H.
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