Results 151 to 160 of about 1,829 (202)

Senolytic Treatment With Fisetin Reverses Age‐Related Endothelial Dysfunction Partially Mediated by SASP Factor CXCL12

Aging Cell, Volume 25, Issue 5, -Not available-.
Single‐cell transcriptomics identifies that oral, intermittent fisetin supplementation improves endothelial function by targeting senescent endothelial cell‐derived senescence‐associated secretory phenotype (SASP) factors and CXCL12 in old animals. The SASP and specifically CXCL12 were found to drive age‐related endothelial dysfunction by promoting ...
Sophia A. Mahoney, Krystyna Mazan‐Mamczarz, Dimitrios Tsitsipatis, Nicholas S. VanDongen, Charnae’ Henry‐Smith, Ada N. Okereke, Rachel Munk, Sanna Darvish, Kevin O. Murray, Supriyo De, Myriam Gorospe, Douglas R. Seals, Matthew J. Rossman, Allison B. Herman, Zachary S. Clayton   +14 more
wiley   +1 more source

CXCL12-CXCR4 axis in feline mammary carcinoma

Aging, 2017
openaire   +2 more sources

Decellularized Aged Bruch's Membrane Confers Unique Biochemical Cues to Retinal Pigment Epithelium for In Vitro Modeling of Age‐Related Macular Degeneration

Aging Cell, Volume 25, Issue 5, May 2026.
A Bruchs membrane (BrM) mimic based on aged decellularized BrM was developed and differentially expressed proteins in aged dECM‐BrM that may provide specific biochemical cues fundamental to model AMD in vitro were identified. RPE culture on aged dECM‐BrM developed certain AMD‐like features including reduced TEER and expression of drusen components ...
Blanca Molins, Mercedes Soledad Nabaes Jodar, Eliandre de Oliveira, Josep Maria Estanyol, Esther Peña, Jaione Bezunartea, María Hernández, Marc Figueras‐Roca, Alfredo Adan   +8 more
wiley   +1 more source

Defining the tumor microenvironment of non‐small cell lung cancer

Immunology &Cell Biology, Volume 104, Issue 5, Page 499-518, May‐June 2026.
The tumor microenvironment (TME) in non‐small cell lung cancer is highly heterogeneous, both at a patient level and tumor microenvironment resolution. Defining the tumor microenvironment from patient‐responders and non‐responders will aid in the development of targeted therapeutics specific for each individual patient.
Kidane Siele Embaye, Tony Blick, Vahid Yaghoubi Naei, Ken O'Byrne, Brett G. M. Hughes, Arutha Kulasinghe   +5 more
wiley   +1 more source

From Development to Aging: Dynamic Roles of the Thymic Medulla in T Cell Biology

Immunological Reviews, Volume 339, Issue 1, May 2026.
ABSTRACT The thymic medulla is essential for establishing central tolerance, orchestrating the development of a diverse yet self‐tolerant T cell repertoire, and preventing autoimmunity. This process is primarily mediated through interactions between developing thymocytes and antigen‐presenting cells, including thymic epithelial cells (TECs) and ...
Christina Michalaki, Minahil Sharjeel, Jennifer E. Cowan   +2 more
wiley   +1 more source

The Secretome Derived From Serum‐Free Media of SHED‐MSCs Can Modulate THP‐1‐Derived Macrophage Cells

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Although culturing cells in serum‐free or low‐serum media may lead to reduced cell proliferation, it is crucial to minimise the presence of foreign proteins and other impurities that could compromise the validity of experimental findings on immunomodulation.
Azadeh Mohammad‐Hasani, Saeed Mohammadi, Mohsen Saeidi, Ali Fallah, Ayyoob Khosravi   +4 more
wiley   +1 more source

From Adipose Tissue to Cardiac Repair: Extracellular Vesicles in Cardiovascular Regeneration

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Adipose‐derived extracellular vesicles (ADEVs) secreted by adipose tissue have gained increasing attention due to their regenerative and immunomodulatory properties in cardiovascular diseases. They carry proteins, lipids, and nucleic acids that mediate intercellular communication and influence cardiac pathophysiology. In atherosclerosis, ADEVs
Karolina Ignaczak, Pola Ochocka, Karol Sadowski, Weronika Ploch, Dominika Tomkiel, Mariusz Tomaniak, Wioletta Olejarz   +6 more
wiley   +1 more source

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Pathological roles of the homeostatic chemokine CXCL12

Cytokine and Growth Factor Reviews, 2018
CXCL12 is a CXC chemokine that traditionally has been classified as a homeostatic chemokine. It contributes to physiological processes such as embryogenesis, hematopoiesis and angiogenesis. In contrast to these homeostatic functions, increased expression of CXCL12 in general, or of a specific CXCL12 splicing variant has been demonstrated in various ...
Rik Janssens, Sofie Struyf, Paul Proost
exaly   +3 more sources

CXCL12 and CXCR4 in bone marrow physiology

Expert Review of Hematology, 2010
This article discusses the multiple roles of CXCL12 and its receptor, CXCR4, in bone marrow (BM) hematopoietic stem cell (HSC) development and regulation. CXCL12 interaction with CXCR4 results in effects as varied as cell migration, proliferation and survival or apoptosis.
Richard M Ransohoff
exaly   +3 more sources

CXCL12-CXCL4 heterodimerization prevents CXCL12-driven breast cancer cell migration

Cellular Signalling, 2020
Despite improvements in cancer early detection and treatment, metastatic breast cancer remains deadly. Current therapeutic approaches have very limited efficacy in patients with triple negative breast cancer. Among the many mechanisms associated that contribute to cancer progression, signaling through the CXCL12-CXCR4 is an essential step in cancer ...
Khanh T.P. Nguyen, Lawrence J. Druhan, Belinda R. Avalos, Li Zhai, Lubica Rauova, Irina V. Nesmelova, Didier Dréau   +6 more
openaire   +2 more sources