Results 61 to 70 of about 34,241 (258)

Intracellular Domains of CXCR3 That Mediate CXCL9, CXCL10, and CXCL11 Function [PDF]

Journal of Biological Chemistry, 2004
The chemokine receptor CXCR3 is a G protein-coupled receptor found predominantly on T cells that is activated by three ligands as follows: CXCL9 (Mig), CXCL10 (IP-10), and CXCL11 (I-TAC). Previously, we have found that of the three ligands, CXCL11 is the most potent inducer of CXCR3 internalization and is the physiologic inducer of CXCR3 ...
Richard A, Colvin, Gabriele S V, Campanella, Jieti, Sun, Andrew D, Luster   +3 more
openaire   +2 more sources

Citrobacter rodentium is sensitive to CXCL9-directed bacterial killing.

, 2015
(A) Dose response survival to increasing concentrations of CXCL9. Wild type C. rodentium was exposed to the various concentrations of CXCL9 for 2 h and survival was expressed as a percentage compared to buffer-only controls.
Lydia Xing (688325), Sarah A. Reid-Yu (155164), Brian R. Tuinema (688323), Cherrie N. Small (688324), Brian K. Coombes (155185)   +4 more
core   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Dose-response of CXCL9 and CCL28 on promastigotes.

, 2013
Reduction of mitochondrial activity in the MTT-assay, as a measure of cytotoxic activity of CXCL9 and CCL28 on the promastigotes after 4 hrs of incubation with the chemokines in concentrations from 25 to 0.16 µM, with CCL3 for comparison, all assayed ...
Matthias Mörgelin (109607), Paul Bates (134046), Mattias Collin (62685), Arne Egesten (365606), Oonagh Shannon (194608), Sara K. Söbirk (393666)   +5 more
core   +1 more source

Antimicrobial activity and regulation of CXCL9 and CXCL10 in oral keratinocytes [PDF]

, 2016
Chemokine (C-X-C motif) ligand (CXCL)9 and CXCL10 are dysregulated in oral inflammatory conditions, and it is not known if these chemokines target microorganisms that form oral biofilm.
Celentano, A, Porter, Stephen, Cirillo, N, Alison Marshall, MIGNOGNA, MICHELE DAVIDE, Antonio Celentano, Cirillo, Nicola, Michael McCullough, Mignogna, MD, Nicola Cirillo, Marshall, A, Marshall, Alison, Porter, S, McCullough, M, Stephen Porter, Celentano, Antonio, Mccullough, Michael, Michele D. Mignogna   +17 more
core   +1 more source

Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain

Advanced Science, EarlyView.
Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh, Hosni Cherif, Matthew Mannarino, Juiena Sagir, Magali Millecamps, Jean A. Ouellet, Laura S. Stone, Lisbet Haglund   +7 more
wiley   +1 more source

CXCL9 as a Prognostic Inflammatory Marker in Early-Stage Lung Adenocarcinoma Patients

Frontiers in Oncology, 2020
Background: This study was performed to evaluate the value of inflammatory biomarkers in predicting the prognosis of early-stage (stage IA-IIB) lung adenocarcinoma.Methods: Ten inflammatory biomarkers were tested with a Luminex bead-based assay in early ...
Yanwei Zhang, Beibei Sun, Minjuan Hu, Yuqing Lou, Jun Lu, Xueyan Zhang, Huimin Wang, Jialin Qian, Tianqing Chu, Baohui Han   +9 more
doaj   +1 more source

Radiotherapy Enhances the Oncolytic Efficacy of the Novel Oncolytic Herpesvirus VG161 and Amplifies Its Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
RT promotes VG161 replication in BC and its immunostimulatory transgenes expression, which is mediated by the upregulation of GADD34 and HVEM caused by RT. The combination therapy with VG161 and RT increases the abundances of tumor‐infiltrating lymphocytes and elicits potent systemic antitumor immunity, thereby effectively inhibiting local tumors and ...
Lijuan Lyu, Ming Yi, Ji Chen, Zeda Zhao, Ruocen Liao, Yingnan Wang, Shengtao Hu, Jun Ding, Ronghua Zhao, William Jia, Yinan Shen, Yongchang Wei, Kongming Wu, Zhijun Dai   +13 more
wiley   +1 more source

Delivery of CXCL9/10/11 plasmid DNAs promotes the tumor-infiltration of T cells and synergizes with PD1 antibody for treating lung cancer

Cancer Nanotechnology, 2022
Background Immune checkpoint blockade (ICB)-based cancer immunotherapy presents promising efficacy in cancer treatment. However, only a small portion of patients show responsiveness to the treatment, which is partially caused by limited tumor ...
Yuxia Ma, Yi Liu, Ying Zhi, Haibin Wang, Mei Yang, Jieting Niu, Li Zhao, Pengsheng Wang   +7 more
doaj   +1 more source

CXCL9 regulates acetaminophen‑induced liver injury via CXCR3

Experimental and Therapeutic Medicine, 2019
Drug-induced liver injury has become a serious public health problem. Although the mechanism of acetaminophen (APAP)-induced liver injury has been studied for decades it has not been fully elucidated. In-depth study into the mechanisms underlying APAP-induced liver injury may provide useful information for more effective prevention and treatment.
Song, Xi, Shen, Yuying, Lao, Yiqun, Tao, Zhen, Zeng, Juan, Wang, Jihui, Wu, Huiling   +6 more
openaire   +3 more sources