Results 221 to 230 of about 142,759 (329)

Identification of Crucial Drug Targets and Pathways to Reprogram Drug Resistance Through Epigenetic Modulation in Advanced Lung Cancer Using Integrated Bioinformatics Approach

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Resistance to chemotherapy, which is demonstrated in almost every patient with advanced‐stage lung cancer (ALC), underscores an urgent need to unravel the underlying molecular mechanisms and identify novel strategies to overcome drug resistance. In the present study, an attempt was made to identify epigenetic targets and modulators that can be
Okibur Rahman, Mossammat Rima Akter, Nur Alam   +2 more
wiley   +1 more source

The CXCL12/CXCR4 Axis in Sepsis-Induced Acute Lung Injury: Mechanisms and Therapeutic Potential. [PDF]

Curr Issues Mol Biol
Luo R, Fan Q, Chen Q, Nie Z, Dan L, Xie S.   +5 more
europepmc   +1 more source

Exogenous ubiquitin attenuates hypoxia/reoxygenation-induced cardiac myocyte apoptosis via the involvement of CXCR4 and modulation of mitochondrial homeostasis

, 2020
Suman Dalal, Christopher R. Daniels, Ying Li, Gary L. Wright, Mahipal Singh, Krishna Singh   +5 more
openalex   +2 more sources

Modulatory effects of trophoblast-secreted CXCL12 on the migration and invasion of human first-trimester decidual epithelial cells are mediated by CXCR4 rather than CXCR7 [PDF]

, 2018
Jia‐Yi Zheng, Haiping Wang, Wenhui Zhou   +2 more
openalex   +1 more source

Metabolic‐immune interactions in gastric cancer T cells: A single‐cell atlas for prognostic biomarker identification

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract Metabolic alterations and immune dysfunction within the gastric tumor microenvironment critically drive gastric cancer (GC) progression and therapeutic resistance. Although single‐cell RNA sequencing (scRNA‐seq) has unveiled cellular heterogeneity in GC, the metabolic landscapes of tumor cells and their interplay with immune components remain ...
Junjun Liu, Rui Zhao, Guodong Yao, Zhao Liu, Runze Shi, Jingshu Geng, Guanying Liang, Kexin Chen   +7 more
wiley   +1 more source

CXCR4 antagonism corrects neutrophil abnormalities and reduces pneumonia severity in a pharmacological mouse model of CXCR2 loss-of-function-mediated neutropenia. [PDF]

Front Immunol
Nguyen CH, Zmajkovicova K, Sekirnik A, Taplin S, Defontis M, Bledsoe JR, Taveras AG, Karlsson L, Johnson R.   +8 more
europepmc   +1 more source

Alternative Coreceptor Requirements for Efficient CCR5- and CXCR4-Mediated HIV-1 Entry into Macrophages

, 2011
Kieran Cashin, Michael Roche, Jasminka Sterjovski, Anne Ellett, Lachlan Gray, Anthony L. Cunningham, Paul A. Ramsland, Melissa J. Churchill, Paul R. Gorry   +8 more
openalex   +2 more sources

CXCR4 Gene Mutation [PDF]

, 2020
openaire   +1 more source

Protein design and RNA design: Perspectives

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract Advances in deep learning and generative modeling have transformed the landscape of protein and RNA design, enabling rapid and precise creation of novel biomolecules with tailored structures and functions. In protein design, generative deep learning frameworks now support backbone generation, sequence optimization, and joint sequence–structure
Xi Chen, Xu Dai, Peilong Lu
wiley   +1 more source

TR-FRET between engineered nanobodies reveals the existence of endogenous CXCR4 oligomers. [PDF]

Commun Biol
Heuninck J, Bobkov V, Grison CM, Fumagalli A, Lescuyer M, Otun O, Bechara C, Lamarque L, Trinquet E, Bachelerie F, Marin P, Mouillac B, Granier S, van der Woning B, de Haard H, Smit MJ, Heukers R, Durroux T.   +17 more
europepmc   +1 more source