Results 231 to 240 of about 157,119 (339)

Gene therapy via CRISPR/Cas9-mediated Cxcr4 disease allele inactivation reverses leukopenia in WHIM mice. [PDF]

J Clin Invest
Gao JL, Li Z, Calderon-Perez R, Pavek A, Kim L, McDermott DH, Murphy PM.   +6 more
europepmc   +1 more source

Identification of Crucial Drug Targets and Pathways to Reprogram Drug Resistance Through Epigenetic Modulation in Advanced Lung Cancer Using Integrated Bioinformatics Approach

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Resistance to chemotherapy, which is demonstrated in almost every patient with advanced‐stage lung cancer (ALC), underscores an urgent need to unravel the underlying molecular mechanisms and identify novel strategies to overcome drug resistance. In the present study, an attempt was made to identify epigenetic targets and modulators that can be
Okibur Rahman, Mossammat Rima Akter, Nur Alam   +2 more
wiley   +1 more source

Metabolic‐immune interactions in gastric cancer T cells: A single‐cell atlas for prognostic biomarker identification

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract Metabolic alterations and immune dysfunction within the gastric tumor microenvironment critically drive gastric cancer (GC) progression and therapeutic resistance. Although single‐cell RNA sequencing (scRNA‐seq) has unveiled cellular heterogeneity in GC, the metabolic landscapes of tumor cells and their interplay with immune components remain ...
Junjun Liu, Rui Zhao, Guodong Yao, Zhao Liu, Runze Shi, Jingshu Geng, Guanying Liang, Kexin Chen   +7 more
wiley   +1 more source

Based on single-cell and transcriptome analysis of inflammatory pathway biomarkers and their molecular mechanisms in chronic obstructive pulmonary disease. [PDF]

PLoS One
Zhou Y, Gong H, Hao Z, Wang L, Li L, Zou X.   +5 more
europepmc   +1 more source

Protein design and RNA design: Perspectives

Quantitative Biology, Volume 14, Issue 2, June 2026.
Abstract Advances in deep learning and generative modeling have transformed the landscape of protein and RNA design, enabling rapid and precise creation of novel biomolecules with tailored structures and functions. In protein design, generative deep learning frameworks now support backbone generation, sequence optimization, and joint sequence–structure
Xi Chen, Xu Dai, Peilong Lu
wiley   +1 more source

CXCR4 induces memory formation over exhaustion in CAR-T cells to achieve durable leukemia targeting. [PDF]

Nat Commun
Itoh-Nakadai A, Liang M, Shindo M, Bibi C, Tomizawa-Murasawa M, Fujiki S, Kaneko A, Kanamaru E, Hashimoto M, Kajita H, Ando Y, Kojima M, Moody J, Iwasaki M, Takagi S, Nakagawa R, Agrawal S, Amitani-Iijima H, Sato K, Sorimachi Y, Suzuki N, Fukami T, Hanada K, Morita S, Katsura K, Matsumoto T, Kobayashi M, Kato M, Negishi Y, Shirouzu M, Najima Y, Takubo K, Hon CC, Uchida N, Taniguchi S, Momozawa Y, Carninci P, Shultz LD, Saito Y, de Hoon M, Shin JW, Ishikawa F.   +41 more
europepmc   +1 more source

HIV-1 and SIV Infection are associated with early loss of lung interstitial CD4+ T cells and dissemination of pulmonary tuberculosis [PDF]

, 2019
et al,, Khader, Shabaana A
core   +1 more source

The Role of 68Ga-Pentixafor and 18F-Fluorodeoxyglucose (18F-FDG) PET/CT in a Case of Multiple Myeloma. [PDF]

Cureus
Kumar A, Chaudhuri T, Pradhan M, Singh P, Gupta B.   +4 more
europepmc   +1 more source

Atypical metastatic osteosarcoma pattern in a dog: Lymphatic, neurovascular and subcutaneous metastasis

Veterinary Record Case Reports, Volume 14, Issue 2, May 2026.
Abstract A 6‐year‐old, spayed, female labrador retriever was presented with left distal radial swelling. Imaging, cytology and biopsy identified an aggressive radial lesion with metastasis to the left axillary lymph node, and a diagnosis of presumptive osteosarcoma was made.
Veronica Perez‐Rodriguez, Laura Venner, Rowan Milner, Jishnu Rao Gutti, Elizabeth A. Maxwell   +4 more
wiley   +1 more source

Evaluating chronic bone and soft tissue infections with [⁶⁸Ga]Ga-Pentixafor PET/CT: a head-to-head comparison with scintigraphy. [PDF]

Eur J Nucl Med Mol Imaging
Denizmen Zorba D, Has Simsek D, Sanli Y, Karacam MI, Ergin ON, Cagatay AA, Buyukkaya F, Kuyumcu S.   +7 more
europepmc   +1 more source