Results 291 to 300 of about 157,119 (339)

Frequent Detection of HIV-1 Variants With Mixed Coreceptor Usage Among People Who Inject Drugs Infected With CRF01_AE: Possible Association With Coreceptor Switch. [PDF]

Open Forum Infect Dis
Maeda Y, Chikata T, Kuwata T, Terasawa H, Van Tran G, Matsushita S, Sawa T, Hasebe F, Takiguchi M.   +8 more
europepmc   +1 more source

Nanoparticle Immunoadjuvant Complexes Augment Germinal Center Responses to Vaccination

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Scaffolding IL‐21 on the surface of a self‐assembling nanoparticle immunogen drives improved germinal center and humoral immune responses. These nanoparticle immunoadjuvant complexes (NICs) functionally modulate the germinal center driving improved somatic hypermutation and antibody maturation, suggesting this platform has potential utility as a ...
Nicholas J. Tursi, Colby J. Agostino, Jinwei Huang, Toshitha Kannan, Niklas Laenger, Jennifer Londregan, Katlyn Lederer, Michaela Helble, Nicole Bedanova, Cory Livingston, Ebony N. Gary, Madison McCanna, Marta Tarquis Medina, Rumi Habib, Ignacio Rodriguez Relaño, Ivan Maillard, Ami Patel, David Allman, Andrew Kossenkov, Amelia Escolano, Daniel W. Kulp, David. B. Weiner   +21 more
wiley   +1 more source

CXCR4 antagonism corrects neutrophil abnormalities and reduces pneumonia severity in a pharmacological mouse model of CXCR2 loss-of-function-mediated neutropenia. [PDF]

Front Immunol
Nguyen CH, Zmajkovicova K, Sekirnik A, Taplin S, Defontis M, Bledsoe JR, Taveras AG, Karlsson L, Johnson R.   +8 more
europepmc   +1 more source

Senescent Synovial Intimal Fibroblasts Aggravate Osteoarthritis by Regulating Macrophage Polarization and Chondrocyte Phenotype Through ANGPTL4‐α5β1 Axis

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Senescent synovial intimal fibroblasts (SIF) are identified as key drivers of osteoarthritis. They promote M1 macrophage polarization and cartilage degeneration via the ANGPTL4–α5β1 axis, regulated by transcription factors EGR1 and ATF3. Pharmacological inhibition of this pathway alleviates disease, revealing SIF senescence as a promising therapeutic ...
Muhai Deng, Yunsheng Jiang, Zhiyu Chen, Kaiquan Chen, Na Cao, Yang Huang, Zhengxue Quan, Cheng Chen   +7 more
wiley   +1 more source

TR-FRET between engineered nanobodies reveals the existence of endogenous CXCR4 oligomers. [PDF]

Commun Biol
Heuninck J, Bobkov V, Grison CM, Fumagalli A, Lescuyer M, Otun O, Bechara C, Lamarque L, Trinquet E, Bachelerie F, Marin P, Mouillac B, Granier S, van der Woning B, de Haard H, Smit MJ, Heukers R, Durroux T.   +17 more
europepmc   +1 more source

Resilient Calvarial Bone Marrow Supports Retinal Repair in Type 2 Diabetes

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Skull bone (calvarium) marrow in diabetic mice stay structurally intact and keeps making blood cells, unlike the bone marrow of the leg bones. The skull marrow is exposed to cerebrospinal fluid (CSF), which contains protective molecules called oxysterols.
Bright Asare‐Bediako, Sergio Li Calzi, Julia G. Behnsen, Ram Prasad, Magdalena Blaszkiewicz, Yvonne Adu‐Rutledge, Robert F. Rosencrans, Jason L. Floyd, Ashley Rennhack, Denise Stanford, Anna Lin, Todd A. Lydic, Carl M. Sheridan, Michael E. Boulton, Kristy L. Townsend, Julia V. Busik, Maria B. Grant   +16 more
wiley   +1 more source

Erratum: [Corrigendum] Targeted silencing of CXCR4 inhibits epithelial-mesenchymal transition in oral squamous cell carcinoma. [PDF]

Oncol Lett
Duan Y, Zhang S, Wang L, Zhou X, He Q, Liu S, Yue K, Wang X.   +7 more
europepmc   +1 more source

TGFβ-activated PDHB promotes mitochondrial pyruvate metabolism and contributes to human endoderm differentiation via ATP-dependent BRG1. [PDF]

Nat Commun
Meng L, Lv J, Yi Y, Lan X, Yan C, Zhu L, Yang J, Jiang W.   +7 more
europepmc   +1 more source

CXCR4-targeted therapy in lung cancer: plerixafor as a promising antimetastatic agent. [PDF]

Front Pharmacol
Ramalingam PS, Afzal M, Babu MA, Rekha MM, Sahoo S, Pandey SN, Goyal K, Hussain MS, Gupta G, Balakrishnan P, Arumugam S.   +10 more
europepmc   +1 more source

CCR5 Utilization of Transmitted and Early Founder HIV-1 Envelopes and the Sensitivity to Small CCR5 Inhibitors [PDF]

, 2008
Hu, Q, Huang, X, Shattock, RJ
core