Molecular bases of catalysis and ADP-ribose preference of human Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase and conversion by mutagenesis to a preferential cyclic ADP-ribose phosphohydrolase. [PDF]
PLoS ONE, 2015 Among metallo-dependent phosphatases, ADP-ribose/CDP-alcohol diphosphatases form a protein family (ADPRibase-Mn-like) mainly restricted, in eukaryotes, to vertebrates and plants, with preferential expression, at least in rodents, in immune cells. Rat and
Alicia Cabezas +8 more
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Does Cyclic ADP-Ribose (cADPR) Activate the Non-selective Cation Channel TRPM2? [PDF]
Frontiers in Immunology, 2020 TRPM2 is a non-selective, Ca2+-permeable cation channel widely expressed in immune cells. It is firmly established that the channel can be activated by intracellular adenosine 5′-diphosphoribose (ADPR).
Ralf Fliegert +2 more
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Inhibition of CD38/Cyclic ADP-ribose Pathway Protects Rats against Ropivacaine-induced Convulsion [PDF]
Chinese Medical Journal, 2017 Background: The CD38/cyclic ADP-ribose (cADPR) pathway plays a role in various central nervous system diseases and in morphine tolerance, but its role in local anesthetic intoxication is unknown.
Yu Zou +3 more
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Cyclic ADP-ribose and heat regulate oxytocin release via CD38 and TRPM2 in the hypothalamus during social or psychological stress in mice [PDF]
Frontiers in Neuroscience, 2016 Hypothalamic oxytocin (OT) is released into the brain by cyclic ADP-ribose (cADPR) with or without depolarizing stimulation. Previously, we showed that the intracellular free calcium concentration ([Ca2+]i) that seems to trigger OT release can be ...
Jing Zhong +18 more
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Molecular characterization of a novel intracellular ADP-ribosyl cyclase.
PLoS ONE, 2007 BackgroundADP-ribosyl cyclases are remarkable enzymes capable of catalyzing multiple reactions including the synthesis of the novel and potent intracellular calcium mobilizing messengers, cyclic ADP-ribose and NAADP.
Dev Churamani +9 more
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Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling. [PDF]
Science, 2022 Cyclic ADP ribose (cADPR) isomers are signaling molecules produced by bacterial and plant Toll/interleukin-1 receptor (TIR) domains via NAD+ hydrolysis.
Manik MK +28 more
europepmc +3 more sources
A Cell-Permeant Mimetic of NMN Activates SARM1 to Produce Cyclic ADP-Ribose and Induce Non-apoptotic Cell Death [PDF]
iScience, 2019 Summary: SARM1, an NAD-utilizing enzyme, regulates axonal degeneration. We show that CZ-48, a cell-permeant mimetic of NMN, activated SARM1 in vitro and in cellulo to cyclize NAD and produce a Ca2+ messenger, cADPR, with similar efficiency as NMN ...
Zhi Ying Zhao +13 more
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Cyclic ADP Ribose Hydrolase (CD38) Inhibitors. [PDF]
ACS Med Chem Lett, 2022 Blass BE.
europepmc +4 more sources
Cyclic ADP-Ribose and Calcium Signaling in Eggs
Neurosignals, 1996 Cyclic ADP-ribose is a cyclic nucleotide with Ca2+ signaling functions. It was first discovered in sea urchin eggs and has since been shown to be active in a variety of cells. Another Ca2+ release mechanism recently described in the eggs is mediated by nicotinic acid dinucleotide phosphate, a derivative of NADP+. This article summarizes current results
Lee, HC
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Crystal structures and snapshots along Tpt1-catalyzed phosphate transfer from nucleic acid to NAD+ [PDF]
Nature CommunicationsTpt1/TRPT1/KptA family proteins are evolutionarily conserved in all three domains of life. In fungi and plants, Tpt1 transfers 2’-PO4 2- from tRNA splice junction to NAD+, which is the final step of tRNA maturation and is critical for the function of ...
Chulei Cao +17 more
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