Results 11 to 20 of about 518,869 (283)
Molecular characterization of a novel intracellular ADP-ribosyl cyclase. [PDF]
PLoS ONE, 2007 BackgroundADP-ribosyl cyclases are remarkable enzymes capable of catalyzing multiple reactions including the synthesis of the novel and potent intracellular calcium mobilizing messengers, cyclic ADP-ribose and NAADP.
Dev Churamani +9 more
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Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling. [PDF]
Science, 2022 Cyclic ADP ribose (cADPR) isomers are signaling molecules produced by bacterial and plant Toll/interleukin-1 receptor (TIR) domains via NAD+ hydrolysis.
Manik MK +28 more
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Cyclic ADP-Ribose and Calcium Signaling in Eggs
Neurosignals, 1996 Cyclic ADP-ribose is a cyclic nucleotide with Ca2+ signaling functions. It was first discovered in sea urchin eggs and has since been shown to be active in a variety of cells. Another Ca2+ release mechanism recently described in the eggs is mediated by nicotinic acid dinucleotide phosphate, a derivative of NADP+. This article summarizes current results
Lee, HC
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Specific cyclic ADP-ribose phosphohydrolase obtained by mutagenic engineering of Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase. [PDF]
Sci Rep, 2018 Cyclic ADP-ribose (cADPR) is a messenger for Ca2+ mobilization. Its turnover is believed to occur by glycohydrolysis to ADP-ribose. However, ADP-ribose/CDP-alcohol diphosphatase (ADPRibase-Mn) acts as cADPR phosphohydrolase with much lower efficiency ...
Ribeiro JM +7 more
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Molecular Brain, 2021 Fear conditioning and retrieval are suitable models to investigate the biological basis of various mental disorders. Hippocampus and amygdala neurons consolidate conditioned stimulus (CS)-dependent fear memory.
Yoonjeong Jeon +3 more
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Frontiers in Physiology, 2020 In addition to its central role in mediating oxidation reduction in fuel metabolism and bioenergetics, nicotinamide adenine dinucleotide (NAD+) has emerged as a vital co-substrate for a number of proteins involved in diverse cellular processes, including
Weiyi Xu, Le Li, Le Li, Lilei Zhang
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Apprehending the NAD+–ADPr-Dependent Systems in the Virus World
Viruses, 2022 NAD+ and ADP-ribose (ADPr)-containing molecules are at the interface of virus–host conflicts across life encompassing RNA processing, restriction, lysogeny/dormancy and functional hijacking.
Lakshminarayan M. Iyer +3 more
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Snake venom NAD glycohydrolases: primary structures, genomic location, and gene structure [PDF]
PeerJ, 2019 NAD glycohydrolase (EC 3.2.2.5) (NADase) sequences have been identified in 10 elapid and crotalid venom gland transcriptomes, eight of which are complete.
Ivan Koludarov, Steven D. Aird
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Identification of a common non-apoptotic cell death mechanism in hereditary retinal degeneration. [PDF]
PLoS ONE, 2014 Cell death in neurodegenerative diseases is often thought to be governed by apoptosis; however, an increasing body of evidence suggests the involvement of alternative cell death mechanisms in neuronal degeneration.
Blanca Arango-Gonzalez +16 more
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Roles of Nicotinamide Adenine Dinucleotide (NAD+) in Biological Systems
Challenges, 2018 NAD+ has emerged as a crucial element in both bioenergetic and signaling pathways since it acts as a key regulator of cellular and organism homeostasis. NAD+ is a coenzyme in redox reactions, a donor of adenosine diphosphate-ribose (ADPr) moieties in ADP-
Palmiro Poltronieri, Nataša Čerekovic
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