Apprehending the NAD+–ADPr-Dependent Systems in the Virus World
Viruses, 2022 NAD+ and ADP-ribose (ADPr)-containing molecules are at the interface of virus–host conflicts across life encompassing RNA processing, restriction, lysogeny/dormancy and functional hijacking.
Lakshminarayan M. Iyer +3 more
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Snake venom NAD glycohydrolases: primary structures, genomic location, and gene structure [PDF]
PeerJ, 2019 NAD glycohydrolase (EC 3.2.2.5) (NADase) sequences have been identified in 10 elapid and crotalid venom gland transcriptomes, eight of which are complete.
Ivan Koludarov, Steven D. Aird
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Identification of a common non-apoptotic cell death mechanism in hereditary retinal degeneration. [PDF]
PLoS ONE, 2014 Cell death in neurodegenerative diseases is often thought to be governed by apoptosis; however, an increasing body of evidence suggests the involvement of alternative cell death mechanisms in neuronal degeneration.
Blanca Arango-Gonzalez +16 more
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Roles of Nicotinamide Adenine Dinucleotide (NAD+) in Biological Systems
Challenges, 2018 NAD+ has emerged as a crucial element in both bioenergetic and signaling pathways since it acts as a key regulator of cellular and organism homeostasis. NAD+ is a coenzyme in redox reactions, a donor of adenosine diphosphate-ribose (ADPr) moieties in ADP-
Palmiro Poltronieri, Nataša Čerekovic
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Paracrine ADP Ribosyl Cyclase-Mediated Regulation of Biological Processes
Cells, 2022 ADP-ribosyl cyclases (ADPRCs) catalyze the synthesis of the Ca2+-active second messengers Cyclic ADP-ribose (cADPR) and ADP-ribose (ADPR) from NAD+ as well as nicotinic acid adenine dinucleotide phosphate (NAADP+) from NADP+. The best characterized ADPRC
Cecilia Astigiano +7 more
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CD38/cADPR Signaling Pathway in Airway Disease: Regulatory Mechanisms
Mediators of Inflammation, 2018 Asthma is an inflammatory disease in which proinflammatory cytokines have a role in inducing abnormalities of airway smooth muscle function and in the development of airway hyperresponsiveness.
Deepak A. Deshpande +6 more
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Enhanced sensitivity to cholera toxin in female ADP-ribosylarginine hydrolase (ARH1)-deficient mice.
PLoS ONE, 2018 Cholera toxin, an 84-kDa multimeric protein and a major virulence factor of Vibrio cholerae, uses the ADP-ribosyltransferase activity of its A subunit to intoxicate host cells.
Kizuku Watanabe +5 more
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Cyclic ADP-Ribose and Hydrogen Peroxide Synergize with ADP-Ribose in the Activation of TRPM2 Channels [PDF]
Molecular Cell, 2005 The melastatin-related transient receptor potential channel TRPM2 is a plasma membrane Ca2+-permeable cation channel that is activated by intracellular adenosine diphosphoribose (ADPR) binding to the channel's enzymatic Nudix domain. Channel activity is also seen with nicotinamide dinucleotide (NAD+) and hydrogen peroxide (H2O2), but their mechanisms ...
Kolisek, Martin +3 more
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Beilstein Journal of Organic Chemistry, 2015 Cyclic N1-pentylinosine monophosphate (cpIMP), a novel simplified inosine derivative of cyclic ADP-ribose (cADPR) in which the N1-pentyl chain and the monophosphate group replace the northern ribose and the pyrophosphate moieties, respectively, was ...
Ahmed Mahal +9 more
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CD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5'-Diphosphate Ribose Template. [PDF]
PLoS ONE, 2013 Few inhibitors exist for CD38, a multifunctional enzyme catalyzing the formation and metabolism of the Ca(2+)-mobilizing second messenger cyclic adenosine 5'-diphosphoribose (cADPR).
Christelle Moreau +9 more
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