Results 41 to 50 of about 15,316 (155)
Insights into the mechanism of bovine CD38/NAD+glycohydrolase from the X-ray structures of its Michaelis complex and covalently-trapped intermediates. [PDF]
PLoS ONE, 2012 Bovine CD38/NAD(+)glycohydrolase (bCD38) catalyses the hydrolysis of NAD(+) into nicotinamide and ADP-ribose and the formation of cyclic ADP-ribose (cADPR).
Pascal F Egea +7 more
doaj +1 more source
RIOX1-demethylated cGAS regulates ionizing radiation-elicited DNA repair
Bone Research, 2022 Exposure to radiation causes DNA damage; hence, continuous surveillance and timely DNA repair are important for genome stability. Epigenetic modifications alter the chromatin architecture, thereby affecting the efficiency of DNA repair.
Yanxuan Xiao +11 more
doaj +1 more source
Nanobody-Based Biologics for Modulating Purinergic Signaling in Inflammation and Immunity
Frontiers in Pharmacology, 2018 Adenosine triphosphate (ATP) and nicotinamide adenine dinucleotide (NAD+) are released as danger signals from cells during infection and sterile inflammation.
Stephan Menzel +3 more
doaj +1 more source
PLoS ONE, 2021 Pancreatic islet β-cell dysfunction is characterized by defective glucose-stimulated insulin secretion (GSIS) and is a predominant component of the pathophysiology of diabetes.
Sophie Hallakou-Bozec +4 more
doaj +1 more source
Vasodilation by the Calcium-mobilizing Messenger Cyclic ADP-ribose [PDF]
Journal of Biological Chemistry, 2003 In artery smooth muscle, adenylyl cyclase-coupled receptors such as beta-adrenoceptors evoke Ca(2+) signals, which open Ca(2+)-activated potassium (BK(Ca)) channels in the plasma membrane. Thus, blood pressure may be lowered, in part, through vasodilation due to membrane hyperpolarization.
Boittin, F +4 more
openaire +2 more sources
Modulation of store-operated Ca2+ entry by cyclic-ADP-ribose
Brazilian Journal of Medical and Biological Research, 2006 Store-operated Ca2+ entry plays an important role in Ca2+ homeostasis in cells but the mechanisms of control of these channels are not completely understood. We describe an investigation of the role of the CD38-cyclic-ADP-ribose (cADPR)-ryanodine-channel
Thompson M., White T., Chini E.N.
doaj
Design, Synthesis and SAR Studies of NAD Analogues as Potent Inhibitors towards CD38 NADase
Molecules, 2014 Nicotinamide adenine dinucleotide (NAD), one of the most important coenzymes in the cells, is a substrate of the signaling enzyme CD38, by which NAD is converted to a second messenger, cyclic ADP-ribose, which releases calcium from intracellular calcium ...
Shengjun Wang +8 more
doaj +1 more source
Cellular Physiology and Biochemistry, 2013 Background/Aims: Despite extensive studies, the intracellular regulatory mechanism of renin production and release is still poorly understood. The present study was designed to test whether CD38-ADP-ribosylcyclase signaling pathway contributes to the ...
Jing Xiong +6 more
doaj +1 more source
PLoS ONE, 2017 Thyroid hormones are well-established as a key regulator of many cellular metabolic pathways developed in various pathogeneses. Here, we dedicated the current work to investigate the role of thyroid hormone analogue (L-thyroxine, L-TH) in regulating the ...
Tarek El-Hamoly +3 more
doaj +1 more source
Genetic Ablation of CD38 Protects against Western Diet-Induced Exercise Intolerance and Metabolic Inflexibility. [PDF]
PLoS ONE, 2015 Nicotinamide adenine dinucleotide (NAD+) is a key cofactor required for essential metabolic oxidation-reduction reactions. It also regulates various cellular activities, including gene expression, signaling, DNA repair and calcium homeostasis ...
Shian-Huey Chiang +16 more
doaj +1 more source