Results 41 to 50 of about 29,382 (269)

Disrupted ADP-ribose metabolism with nuclear Poly (ADP-ribose) accumulation leads to different cell death pathways in presence of hydrogen peroxide in procyclic Trypanosoma brucei [PDF]

, 2016
TbPARG in Trypanosoma brucei. A) TbPARG localization in untreated (control) and in procyclic cultures exposed to 500 μM H2O2 for 10 min. IFI was carried out as reported in our previous work [33].
Harikanth Venkannagari, Lari Lehtiö, Mariana Schlesinger, Mirtha M. Flawiá, Mohit Narwal, Salomé C. Vilchez Larrea, Silvia H. Fernández Villamil, Teemu Haikarainen   +7 more
core   +6 more sources

Characterization of Danio rerio Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase, the structural prototype of the ADPRibase-Mn-like protein family.

PLoS ONE, 2012
The ADPRibase-Mn-like protein family, that belongs to the metallo-dependent phosphatase superfamily, has different functional and structural prototypes.
Joaquim Rui Rodrigues, Ascensión Fernández, José Canales, Alicia Cabezas, João Meireles Ribeiro, María Jesús Costas, José Carlos Cameselle   +6 more
doaj   +1 more source

Acetyl Phosphate as a Primordial Energy Currency at the Origin of Life [PDF]

, 2018
Metabolism is primed through the formation of thioesters via acetyl CoA and the phosphorylation of substrates by ATP. Prebiotic equivalents such as methyl thioacetate and acetyl phosphate have been proposed to catalyse analogous reactions at the origin ...
Camprubi, E, Herschy, B, Lane, N, Pinna, S, Whicher, A   +4 more
core   +1 more source

Solid-Phase Synthesis of a New Diphosphate 5-Aminoimidazole-4-carboxamide Riboside (AICAR) Derivative and Studies toward Cyclic AICAR Diphosphate Ribose

Molecules, 2011
The solid-phase synthesis of the first example of a new diphosphate AICAR derivative is reported. The new substance is characterized by the presence of a 5'-phosphate group while a second phosphate moiety is installed on a 5-hydroxypentyl chain attached ...
Gennaro Piccialli, Vincenzo Piccialli, Luciano Mayol, Michela Varra, Jussara Amato, Nicola Borbone, Giorgia Oliviero, Stefano D’Errico   +7 more
doaj   +1 more source

TRPM2 channel-mediated ROS-sensitive Ca2+ signaling mechanisms in immune cells [PDF]

, 2015
Transient receptor potential melastatin 2 (TRPM2) proteins form Ca2+-permeable cationic channels that are potently activated by reactive oxygen species (ROS).
Alim, Angus, Bartlett, Bedard, Buanne, Burnstock, Cassel, Dheen, Di, Dostert, Du, Duewell, Feske, Gelderblom, Gloire, Halle, Ham, Hanisch, Hara, Haraguchi, Hiroi, Hogan, Holmström, Jiang, Jiang, Jiang, Jiang, Kashio, Kettenmann, Knowles, Knowles, Li, Liao, Martinon, Miyake, Motterlini, Nathan, Nilius, Perraud, Prasad, Qian, Sano, Steinman, Sumazo-Toledo, Sumazo-Toledo, Summers, Sumoza-Toledo, Tschopp, Venkatachalam, Voloshyna, Wehage, Wehrhahn, Yamamoto, Yamamoto, Ye, Zhang, Zhang, Zhong, Zou   +58 more
core   +3 more sources

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18:Enzymes [PDF]

, 2017
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and ...
,, Alexander, Stephen Ph, Davies, Jamie A, Fabbro, Doriano, Faccenda, Elena, Harding, Simon D, Kelly, Eamonn, Marrion, Neil V, Pawson, Adam J, Peters, John A, Sharman, Joanna L, Southan, Christopher   +11 more
core   +15 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Molecular characterization of a novel intracellular ADP-ribosyl cyclase.

PLoS ONE, 2007
BackgroundADP-ribosyl cyclases are remarkable enzymes capable of catalyzing multiple reactions including the synthesis of the novel and potent intracellular calcium mobilizing messengers, cyclic ADP-ribose and NAADP.
Dev Churamani, Michael J Boulware, Timothy J Geach, Andrew C R Martin, Gary W Moy, Yi-Hsien Su, Victor D Vacquier, Jonathan S Marchant, Leslie Dale, Sandip Patel   +9 more
doaj   +1 more source

‘Click cyclic ADP-ribose’: a neutral second messenger mimic [PDF]

Chem. Commun., 2014
Neutral synthetic analogues of the second messenger cADPR with a 1,2,3-triazole pyrophosphate bioisostere retain the ability to activate Ca2+release and to inhibit hydrolysis of cADPR by CD38.
Swarbrick, Joanna M., Graeff, Richard, Garnham, Clive, Thomas, Mark P., Galione, Antony, Potter, Barry V. L.   +5 more
openaire   +3 more sources

Phosphodiesterase inhibition induces retinal degeneration, oxidative stress and inflammation in cone-enriched cultures of porcine retina. [PDF]

, 2013
nherited retinal degenerations affecting both rod and cone photoreceptors constitute one of the causes 74 of incurable blindness in the developed world. Cyclic guanosine monophosphate (cGMP) is crucial in the 75 phototransduction and, mutations in genes ...
Aller Mañas, Elena, García Tárraga, Patricia, García Verdugo, José Manuel, Gómez Pinedo, Ulises, Jaijo, Teresa, Martínez Fernández de la Cámara, Cristina, Millán Salvador, José María, Rodrigo, Regina, Sequedo, María Dolores   +8 more
core   +2 more sources