Expanding the Substrate Specificity of Macro Domains toward 3″-Isomer of O‑Acetyl-ADP-ribose
, 2021 O-Acetyl-ADP-ribose (OAADPR) is a signaling molecule identified from the conserved sirtuin reaction in Saccharomyces cerevisiae, involved in the important cellular functions of gene silencing, redox regulation, and aging.
Yi-Chih Chiu +5 more
core +1 more source
Paracrine ADP Ribosyl Cyclase-Mediated Regulation of Biological Processes
Cells, 2022 ADP-ribosyl cyclases (ADPRCs) catalyze the synthesis of the Ca2+-active second messengers Cyclic ADP-ribose (cADPR) and ADP-ribose (ADPR) from NAD+ as well as nicotinic acid adenine dinucleotide phosphate (NAADP+) from NADP+. The best characterized ADPRC
Cecilia Astigiano +7 more
doaj +1 more source
CD38/cADPR Signaling Pathway in Airway Disease: Regulatory Mechanisms
Mediators of Inflammation, 2018 Asthma is an inflammatory disease in which proinflammatory cytokines have a role in inducing abnormalities of airway smooth muscle function and in the development of airway hyperresponsiveness.
Deepak A. Deshpande +6 more
doaj +1 more source
Hydrolysis of the phosphoanhydride linkage of cyclic ADP-ribose by the Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase [PDF]
, 2009 Cyclic ADP-ribose (cADPR) metabolism in mammals is catalyzed by NAD glycohydrolases (NADases) that, besides forming ADP-ribose, form and hydrolyze the N1-glycosidic linkage of cADPR. Thus far, no cADPR phosphohydrolase was known. We tested rat ADP-ribose/
Cameselle, JC +7 more
core +2 more sources
Enhanced sensitivity to cholera toxin in female ADP-ribosylarginine hydrolase (ARH1)-deficient mice.
PLoS ONE, 2018 Cholera toxin, an 84-kDa multimeric protein and a major virulence factor of Vibrio cholerae, uses the ADP-ribosyltransferase activity of its A subunit to intoxicate host cells.
Kizuku Watanabe +5 more
doaj +1 more source
Cyclic ADP-ribose and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) as Messengers for Calcium Mobilization [PDF]
Journal of Biological Chemistry, 2012 Cheung Lee
exaly +2 more sources
Beilstein Journal of Organic Chemistry, 2015 Cyclic N1-pentylinosine monophosphate (cpIMP), a novel simplified inosine derivative of cyclic ADP-ribose (cADPR) in which the N1-pentyl chain and the monophosphate group replace the northern ribose and the pyrophosphate moieties, respectively, was ...
Ahmed Mahal +9 more
doaj +1 more source
CD38 Structure-Based Inhibitor Design Using the N1-Cyclic Inosine 5'-Diphosphate Ribose Template. [PDF]
PLoS ONE, 2013 Few inhibitors exist for CD38, a multifunctional enzyme catalyzing the formation and metabolism of the Ca(2+)-mobilizing second messenger cyclic adenosine 5'-diphosphoribose (cADPR).
Christelle Moreau +9 more
doaj +1 more source
Nanomaterials, 2021 Cyclic adenosine monophosphate (cAMP) is an important research target because it activates protein kinases, and its signaling pathway regulates the passage of ions and molecules inside a cell.
Yuki Komoto +2 more
doaj +1 more source
A novel mechanism of imeglimin‐mediated insulin secretion via the cADPR‐TRP channel pathway
Journal of Diabetes Investigation, 2022 Aims/Introduction Imeglimin is a novel oral hypoglycemic agent that improves blood glucose levels through multiple mechanisms of action including the enhancement of glucose‐stimulated insulin secretion (GSIS), however, the details of this mechanism have ...
Shunsuke Funazaki +7 more
doaj +1 more source