Paracrine ADP Ribosyl Cyclase-Mediated Regulation of Biological Processes
Cells, 2022 ADP-ribosyl cyclases (ADPRCs) catalyze the synthesis of the Ca2+-active second messengers Cyclic ADP-ribose (cADPR) and ADP-ribose (ADPR) from NAD+ as well as nicotinic acid adenine dinucleotide phosphate (NAADP+) from NADP+. The best characterized ADPRC
Cecilia Astigiano +7 more
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Synthesis and calcium mobilization activity of cADPR analogues which integrate nucleobase, northern and southern ribose modifications [PDF]
, 2012 Novel cADPR mimics, which integrate nucleobase, northern and southern ribose modifications were synthesized. The key steps of the synthesis were a Cu(I)-catalyzed Hüisgen [3+2] cycloaddition and a microwave-assisted intramolecular pyrophosphorylation ...
Jin, H +6 more
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The human NAD metabolome: Functions, metabolism and compartmentalization [PDF]
, 2015 The metabolism of NAD has emerged as a key regulator of cellular and organismal homeostasis. Being a major component of both bioenergetic and signaling pathways, the molecule is ideally suited to regulate metabolism and major cellular events.
Kulikova, Veronika +2 more
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CD38/cADPR Signaling Pathway in Airway Disease: Regulatory Mechanisms
Mediators of Inflammation, 2018 Asthma is an inflammatory disease in which proinflammatory cytokines have a role in inducing abnormalities of airway smooth muscle function and in the development of airway hyperresponsiveness.
Deepak A. Deshpande +6 more
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7-Deaza-8-bromo-cyclic ADP-ribose, the First Membrane-permeant, Hydrolysis-resistant Cyclic ADP-ribose Antagonist [PDF]
Journal of Biological Chemistry, 1997 Cyclic ADP-ribose (cADPR) is a putative second messenger that has been demonstrated to mobilize Ca2+ in many cell types. Its postulated role as the endogenous regulator of ryanodine-sensitive Ca2+ release channels has been greatly supported by the advent and use of specific cADPR receptor antagonists such as 8-NH2-cADPR (Walseth, T. F., and Lee, H. C. (
Sethi, Jaswinder K. +4 more
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Nanomaterials, 2021 Cyclic adenosine monophosphate (cAMP) is an important research target because it activates protein kinases, and its signaling pathway regulates the passage of ions and molecules inside a cell.
Yuki Komoto +2 more
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Mechanisms altering airway smooth muscle cell Ca(2+) homeostasis in two asthma models [PDF]
, 2008 Background: Asthma is characterized by airway remodeling, altered mucus production and airway smooth muscle cell (ASMC) contraction causing extensive airway narrowing. In particular, alterations of ASMC contractility seem to be of crucial importance. The
Bergner, Albrecht +6 more
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Enhanced sensitivity to cholera toxin in female ADP-ribosylarginine hydrolase (ARH1)-deficient mice.
PLoS ONE, 2018 Cholera toxin, an 84-kDa multimeric protein and a major virulence factor of Vibrio cholerae, uses the ADP-ribosyltransferase activity of its A subunit to intoxicate host cells.
Kizuku Watanabe +5 more
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Signaling pathways for transduction of the initial message of the glycocode into cellular responses [PDF]
, 1998 The sugar units of glycan structures store information and establish an alphabet of life. The language of the oligosaccharide coding units is deciphered by receptors such as lectins and the decoded message can be transduced by multiple signaling pathways.
Gabius, Hans-Joachim, Villalobo, A.
core +2 more sources
Beilstein Journal of Organic Chemistry, 2015 Cyclic N1-pentylinosine monophosphate (cpIMP), a novel simplified inosine derivative of cyclic ADP-ribose (cADPR) in which the N1-pentyl chain and the monophosphate group replace the northern ribose and the pyrophosphate moieties, respectively, was ...
Ahmed Mahal +9 more
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