Results 21 to 30 of about 17,158 (246)
Modulation of store-operated Ca2+ entry by cyclic-ADP-ribose
Brazilian Journal of Medical and Biological Research, 2006 Store-operated Ca2+ entry plays an important role in Ca2+ homeostasis in cells but the mechanisms of control of these channels are not completely understood. We describe an investigation of the role of the CD38-cyclic-ADP-ribose (cADPR)-ryanodine-channel
Thompson M., White T., Chini E.N.
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Journal of Biological Chemistry, 1995 Cyclic ADP-ribose (cADPR) is a recently discovered cyclic nucleotide with Ca2+ mobilizing activity. Caged cADPR was synthesized by reacting cADPR with 2-nitrophenethyldiazoethane.
Robert Aarhus, Kyle Gee, Hon Cheung Lee
openaire +2 more sources
Specific cyclic ADP-ribose phosphohydrolase obtained by mutagenic engineering of Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase. [PDF]
Sci Rep, 2018 Cyclic ADP-ribose (cADPR) is a messenger for Ca2+ mobilization. Its turnover is believed to occur by glycohydrolysis to ADP-ribose. However, ADP-ribose/CDP-alcohol diphosphatase (ADPRibase-Mn) acts as cADPR phosphohydrolase with much lower efficiency ...
Ribeiro JM +7 more
europepmc +2 more sources
Cytosolic interaction of type III human CD38 with CIB1 modulates cellular cyclic ADP-ribose levels [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2017 Yong Juan Zhao +2 more
exaly +2 more sources
Maintenance of NAD+ Homeostasis in Skeletal Muscle during Aging and Exercise
Cells, 2022 Nicotinamide adenine dinucleotide (NAD) is a versatile chemical compound serving as a coenzyme in metabolic pathways and as a substrate to support the enzymatic functions of sirtuins (SIRTs), poly (ADP-ribose) polymerase-1 (PARP-1), and cyclic ADP ribose
Li Li Ji, Dongwook Yeo
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Nicotinamide Adenine Dinucleotide (NAD) Metabolism as a Relevant Target in Cancer
Cells, 2022 NAD+ is an important metabolite in cell homeostasis that acts as an essential cofactor in oxidation–reduction (redox) reactions in various energy production processes, such as the Krebs cycle, fatty acid oxidation, glycolysis and serine biosynthesis ...
Lola E. Navas, Amancio Carnero
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Emerging Concepts on the Role of ADP-Ribosylation
Challenges, 2020 NAD+ has emerged as a crucial element in both bioenergetic and signaling pathways, since it acts as a key regulator of cellular and organism homeostasis.
Palmiro Poltronieri
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Molecular Brain, 2021 Fear conditioning and retrieval are suitable models to investigate the biological basis of various mental disorders. Hippocampus and amygdala neurons consolidate conditioned stimulus (CS)-dependent fear memory.
Yoonjeong Jeon +3 more
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Hydrolysis of the phosphoanhydride linkage of cyclic ADP-ribose by the Mn2+-dependent ADP-ribose/CDP-alcohol pyrophosphatase [PDF]
, 2009 Cyclic ADP-ribose (cADPR) metabolism in mammals is catalyzed by NAD glycohydrolases (NADases) that, besides forming ADP-ribose, form and hydrolyze the N1-glycosidic linkage of cADPR. Thus far, no cADPR phosphohydrolase was known. We tested rat ADP-ribose/
Cameselle, JC +7 more
core +2 more sources
Frontiers in Physiology, 2020 In addition to its central role in mediating oxidation reduction in fuel metabolism and bioenergetics, nicotinamide adenine dinucleotide (NAD+) has emerged as a vital co-substrate for a number of proteins involved in diverse cellular processes, including
Weiyi Xu, Le Li, Le Li, Lilei Zhang
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