Results 51 to 60 of about 15,316 (155)

Nitric oxide in plants: a brief discussion on this multifunctional molecule Óxido nítrico em plantas: breve abordagem sobre essa molécula multifuncional

Scientia Agricola, 2010
Several studies were carried out in order to improve the knowledge about the occurrence and activity of nitric oxide (NO) in plants. Thus, this review discusses some aspects related to NO in plants such as chemical properties, synthesis pathways ...
Leonardo Cesar Ferreira, Ana Catarina Cataneo   +1 more
doaj   +1 more source

Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling. [PDF]

Science, 2022
Manik MK, Shi Y, Li S, Zaydman MA, Damaraju N, Eastman S, Smith TG, Gu W, Masic V, Mosaiab T, Weagley JS, Hancock SJ, Vasquez E, Hartley-Tassell L, Kargios N, Maruta N, Lim BYJ, Burdett H, Landsberg MJ, Schembri MA, Prokes I, Song L, Grant M, DiAntonio A, Nanson JD, Guo M, Milbrandt J, Ve T, Kobe B.   +28 more
europepmc   +1 more source

Interactions between intracellular Ca2+ stores: Ca2+ released from the NAADP pool potentiates cADPR-induced Ca2+ release

Brazilian Journal of Medical and Biological Research, 2002
Cells possess multiple intracellular Ca2+-releasing systems. Sea urchin egg homogenates are a well-established model to study intracellular Ca2+ release. In the present study the mechanism of interaction between three intracellular Ca2+ pools, namely the
E.N. Chini
doaj   +1 more source

CD38-Cyclic ADP-Ribose Signal System in Physiology, Biochemistry, and Pathophysiology. [PDF]

Int J Mol Sci, 2022
Takasawa S.
europepmc   +1 more source

Downregulation of the Cd38-Cyclic ADP-Ribose Signaling in Cardiomyocytes by Intermittent Hypoxia via Pten Upregulation. [PDF]

Int J Mol Sci, 2022
Takasawa S, Makino M, Uchiyama T, Yamauchi A, Sakuramoto-Tsuchida S, Itaya-Hironaka A, Takeda Y, Asai K, Shobatake R, Ota H.   +9 more
europepmc   +1 more source

Synthesis and use of cell-permeant cyclic ADP-ribose

Biochemical and Biophysical Research Communications, 2012
Cyclic ADP-ribose (cADPR) is a second messenger that acts on ryanodine receptors to mobilize Ca(2+). cADPR has a net negative charge at physiological pH making it not passively membrane permeant thereby requiring it to be injected, electroporated or loaded via liposomes.
Rosen, D, Bloor-Young, D, Squires, J, Parkesh, R, Waters, G, Vasudevan, SR, Lewis, A, Churchill, G   +7 more
openaire   +2 more sources

Methyltransferase-Like 3 Inhibition-Activated cGAS/STING Axis Enhances Immunotherapy and Poly(ADP-Ribose) Polymerase Inhibitor Sensitivity in Lung Adenocarcinoma

Research
The cyclic GMP-AMP synthase (cGAS)/stimulator of interferon genes (STING)-mediated type I interferon response plays a crucial role in antitumor immunity, yet the regulatory factors involved in this innate immune response remain incompletely understood ...
Jiawang Zhou, Jiaxin He, Yunqing Lu, Cheng Yi, Xing Chang, Lijun Tao, Ke Zhong, Haisheng Zhang, Hongxin Niu, Xiansong Wang, Zhuojia Chen, Hongsheng Wang   +11 more
doaj   +1 more source

Synthesis and biological evaluation of novel photo-clickable adenosine and cyclic ADP-ribose analogs: 8-N₃-2'-O-propargyladenosine and 8-N₃-2'-O-propargyl-cADPR. [PDF]

Bioorg Med Chem, 2022
Andy D, Gunaratne GS, Marchant JS, Walseth TF, Slama JT.   +4 more
europepmc   +1 more source

Deletion of CD38 enhances CD19 chimeric antigen receptor T cell function

Molecular Therapy: Oncology
Cell surface molecules transiently upregulated on activated T cells can play a counter-regulatory role by inhibiting T cell function. Deletion or blockade of such immune checkpoint receptors has been investigated to improve the function of engineered ...
Kimberly Veliz, Feng Shen, Olga Shestova, Maksim Shestov, Alexander Shestov, Sara Sleiman, Tyler Hansen, Roddy S. O’Connor, Saar Gill   +8 more
doaj   +1 more source

Okamoto model for necrosis and its expansions, CD38-cyclic ADP-ribose signal system for intracellular Ca²⁺ mobilization and Reg (Regenerating gene protein)-Reg receptor system for cell regeneration. [PDF]

Proc Jpn Acad Ser B Phys Biol Sci, 2021
Okamoto H, Takasawa S.
europepmc   +1 more source