Results 1 to 10 of about 127,246 (291)
Cyclic AMP induces reversible EPAC1 condensates that regulate histone transcription [PDF]
Nature Communications, 2023 The second messenger cyclic AMP regulates many nuclear processes including transcription, pre-mRNA splicing and mitosis. While most functions are attributed to protein kinase A, accumulating evidence suggests that not all nuclear cyclic AMP-dependent ...
Liliana Felicia Iannucci +15 more
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Special Issue on “New Advances in Cyclic AMP Signalling”—An Editorial Overview [PDF]
Cells, 2020 The cyclic nucleotides 3′,5′-adenosine monophosphate (cyclic AMP) signalling system underlies the control of many biological events and disease processes in man.
Stephen John Yarwood
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Reproduction and Fertility, 2021 In previous studies, we had shown the synergistic effect of 10−5 M forskolin (FSK) on the detection threshold of the cyclic AMP response to luteinizing hormones (LH) and chorionic gonadotropins (CG) from various species in the mouse Leydig tumor cell ...
Danièle Klett, Yves Combarnous
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Nucleotides as Bacterial Second Messengers
Molecules, 2023 In addition to comprising monomers of nucleic acids, nucleotides have signaling functions and act as second messengers in both prokaryotic and eukaryotic cells. The most common example is cyclic AMP (cAMP).
Mario E. Cancino-Diaz +3 more
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Stresses, 2023 The reasons initiating insulin resistance are not identified. Various metabolic derailments have been characterized. These are the outcome and not the initiation of insulin resistance.
Heinrich K. Wasner
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Non-Enzymatic Oligomerization of 3', 5' Cyclic AMP. [PDF]
PLoS ONE, 2016 Recent studies illustrate that short oligonucleotide sequences can be easily produced from nucleotide precursors in a template-free non-enzymatic way under dehydrating conditions, i.e. using essentially dry materials. Here we report that 3',5' cyclic AMP
Giovanna Costanzo +8 more
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Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium
eLife, 2020 Compartmentalization of cellular signaling forms the molecular basis of cellular behavior. The primary cilium constitutes a subcellular compartment that orchestrates signal transduction independent from the cell body.
Jan N Hansen +10 more
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Role of CRTC2 in Metabolic Homeostasis: Key Regulator of Whole-Body Energy Metabolism? [PDF]
Diabetes & Metabolism Journal, 2020 Cyclic adenosine monophosphate (cAMP) signaling is critical for regulating metabolic homeostasis in mammals. In particular, transcriptional regulation by cAMP response element-binding protein (CREB) and its coactivator, CREB-regulated transcription ...
Hye-Sook Han +2 more
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Towards Parsimonious Generative Modeling of RNA Families [PDF]
Nucleic Acids Research, gkae289 (2024), 2023 Generative probabilistic models emerge as a new paradigm in data-driven, evolution-informed design of biomolecular sequences. This paper introduces a novel approach, called Edge Activation Direct Coupling Analysis (eaDCA), tailored to the characteristics of RNA sequences, with a strong emphasis on simplicity, efficiency, and interpretability.
arxiv +1 more source
Molecular Metabolism, 2017 Objective: Upon activation, G protein coupled receptors (GPCRs) associate with heterotrimeric G proteins at the plasma membrane to initiate second messenger signaling. Subsequently, the activated receptor experiences desensitization, internalization, and
Shravan Babu Girada +6 more
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