Results 1 to 10 of about 1,017,209 (339)
Nanobody-directed targeting of optogenetic tools to study signaling in the primary cilium
eLife, 2020 Compartmentalization of cellular signaling forms the molecular basis of cellular behavior. The primary cilium constitutes a subcellular compartment that orchestrates signal transduction independent from the cell body.
Jan N Hansen +10 more
doaj +1 more source
Adrenomedullin increases cAMP accumulation and BDNF expression in rat DRG and spinal motor neurons [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): Adrenomedullin (AM) has high expression in the spinal cord. In this study, we investigated the expression of AM and its receptor components, including calcitonin receptor-like receptor (CLR) and receptor activity modifying proteins (RAMPs ...
Mohsen Sisakht +4 more
doaj +1 more source
Cyclic AMP signalling in pancreatic islets [PDF]
, 2010 Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet β-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in ...
Furman, Brian +2 more
core +1 more source
Relationship between the tissue level of cyclic AMP and the fat cell size of human adipose tissue.
Journal of Lipid Research, 1978 The relationship between mean fat cell size, maximal tissue cyclic AMP concentration, and glycerol release was investigated in human subcutaneous adipose tissue incubated in vitro with or without isoprenaline or noradrenaline added at maximal effective ...
P Arner, J Ostman
doaj +1 more source
Journal of Neuroinflammation, 2016 BackgroundMicroglia and macrophages play a central role in neuroinflammation. Pro-inflammatory cytokines trigger their conversion to a classically activated (M1) phenotype, sustaining inflammation and producing a cytotoxic environment.
M. Ghosh, Yong Xu, D. Pearse
semanticscholar +1 more source
Copper Regulates Cyclic AMP-Dependent Lipolysis
Nature Chemical Biology, 2016 Cell signaling relies extensively on dynamic pools of redox-inactive metal ions such as sodium, potassium, calcium, and zinc, but their redox-active transition metal counterparts such as copper and iron have been studied primarily as static enzyme ...
Lakshmi Krishnamoorthy +15 more
semanticscholar +1 more source
Molecular Metabolism, 2017 Objective: Upon activation, G protein coupled receptors (GPCRs) associate with heterotrimeric G proteins at the plasma membrane to initiate second messenger signaling. Subsequently, the activated receptor experiences desensitization, internalization, and
Shravan Babu Girada +6 more
doaj +1 more source
Non-Enzymatic Oligomerization of 3', 5' Cyclic AMP. [PDF]
PLoS ONE, 2016 Recent studies illustrate that short oligonucleotide sequences can be easily produced from nucleotide precursors in a template-free non-enzymatic way under dehydrating conditions, i.e. using essentially dry materials. Here we report that 3',5' cyclic AMP
Giovanna Costanzo +8 more
doaj +1 more source
Cyclic AMP metabolism and adenylate cyclase concentration in patients with advanced hepatic cirrhosis [PDF]
, 1978 Glucagon was tested for its effect on plasma adenosine 3′,5′-cyclic monophosphate (cyclic AMP), insulin, and glucose in healthy subjects and in patients with advanced cirrhosis of the liver. In the normal subjects, intravenous infusion of glucagon caused
Antonio Francavilla +61 more
core +1 more source
Nature Communications, 2016 Biguanides such as metformin have previously been shown to antagonize hepatic glucagon-stimulated cyclic AMP (cAMP) signalling independently of AMP-activated protein kinase (AMPK) via direct inhibition of adenylate cyclase by AMP.
M. Johanns +16 more
semanticscholar +1 more source