Results 11 to 20 of about 114,883 (257)
Role of CRTC2 in Metabolic Homeostasis: Key Regulator of Whole-Body Energy Metabolism? [PDF]
Diabetes & Metabolism Journal, 2020 Cyclic adenosine monophosphate (cAMP) signaling is critical for regulating metabolic homeostasis in mammals. In particular, transcriptional regulation by cAMP response element-binding protein (CREB) and its coactivator, CREB-regulated transcription ...
Hye-Sook Han +2 more
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Relationship between the tissue level of cyclic AMP and the fat cell size of human adipose tissue.
Journal of Lipid Research, 1978 The relationship between mean fat cell size, maximal tissue cyclic AMP concentration, and glycerol release was investigated in human subcutaneous adipose tissue incubated in vitro with or without isoprenaline or noradrenaline added at maximal effective ...
P Arner, J Ostman
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Non-Enzymatic Oligomerization of 3', 5' Cyclic AMP. [PDF]
PLoS ONE, 2016 Recent studies illustrate that short oligonucleotide sequences can be easily produced from nucleotide precursors in a template-free non-enzymatic way under dehydrating conditions, i.e. using essentially dry materials. Here we report that 3',5' cyclic AMP
Giovanna Costanzo +8 more
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Short PDE4 Isoforms as Drug Targets in Disease
Frontiers in Bioscience-Landmark, 2023 The second messenger, cyclic adenosine monophosphate (cAMP), is a master regulator of signal transduction that maintains cell homeostasis. A fine balance between cAMP synthesis by adenylyl cyclase and degradation by phosphodiesterases (PDEs) underpins ...
Elka Kyurkchieva, George S. Baillie
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American Journal of Respiratory Cell and Molecular Biology, 2008 Abstract Cyclic adenosine monophosphate (cAMP) was the original “second messenger” to be discovered. Its formation is promoted by adenylyl cyclase activation after ligation of G protein–coupled receptors by ligands including hormones, autocoids, prostaglandins, and pharmacologic agents.
Carlos H. Serezani +3 more
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Molecular Metabolism, 2017 Objective: Upon activation, G protein coupled receptors (GPCRs) associate with heterotrimeric G proteins at the plasma membrane to initiate second messenger signaling. Subsequently, the activated receptor experiences desensitization, internalization, and
Shravan Babu Girada +6 more
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Cells, 2020 The cell cycle is controlled by microtubule-associated serine/threonine kinase-like (MASTL), which phosphorylates the cAMP-regulated phosphoproteins 19 (ARPP19) at S62 and 19e/α-endosulfine (ENSA) at S67and converts them into protein phosphatase 2A (
Elena J. Kumm +6 more
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RAS and beyond: the many faces of the neurofibromatosis type 1 protein
Disease Models & Mechanisms, 2022 Neurofibromatosis type 1 is a rare neurogenetic syndrome, characterized by pigmentary abnormalities, learning and social deficits, and a predisposition for benign and malignant tumor formation caused by germline mutations in the NF1 gene.
Corina Anastasaki +2 more
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Cyclic AMP metabolism in adipose tissue of exercise-trained rats.
Journal of Lipid Research, 1978 Cyclic AMP metabolism in epididymal adipose tissue of exercise-trained rats was examined to determine if training induced changes in cyclic AMP production or inactivation.
E W Askew +3 more
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Cyclic AMP Accumulation in Migraine Induction
Pediatric Neurology Briefs, 2015 Investigators from Danish Headache Centre, Glostrup Hospital, and the University of Copenhagen investigated whether intracellular cyclic AMP accumulation induced migraine attacks among 14 migraine patients without aura.
Ana B Chelse, Leon G Epstein
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