Results 11 to 20 of about 30,015 (162)

Resveratrol inhibits LPS-induced MAPKs activation via activation of the phosphatidylinositol 3-kinase pathway in murine RAW 264.7 macrophage cells. [PDF]

PLoS ONE, 2012
BACKGROUND: Resveratrol is a natural polyphenolic compound that has cardioprotective, anticancer and anti-inflammatory properties. We investigated the capacity of resveratrol to protect RAW 264.7 cells from inflammatory insults and explored mechanisms ...
Yi Zong, Lin Sun, Bin Liu, Yi-Shu Deng, Dong Zhan, Yuan-Li Chen, Ying He, Jing Liu, Zong-Ji Zhang, Jun Sun, Di Lu   +10 more
doaj   +1 more source

Cyclic AMP Response Element-Binding Protein in the Vessel Wall [PDF]

Circulation, 2003
Atherosclerosis and postangioplasty restenosis are leading causes of death in the Western world. Recent advances in our understanding of vascular biology would suggest that targeting specific signals in the post–balloon injury vessel or in persons prone to development of atherosclerosis could decrease lesion formation and in the long term decrease ...
Jane E.B. Reusch, Dwight J. Klemm
openaire   +1 more source

Regulation of Cox-2 by Cyclic AMP Response Element Binding Protein in Prostate Cancer: Potential Role for Nexrutine

Neoplasia: An International Journal for Oncology Research, 2007
We recently showed that NexrutineR, a Phellodendron amurense bark extract, suppresses proliferation of prostate cancer cell lines and tumor development in the transgenic adenocarcinoma of mouse prostate (TRAMP) model.
Rita Ghosh, Gretchen E. Garcia, Katherine Crosby, Hiroyasu Inoue, Ian M. Thompson, Dean A. Troyer, Addanki P. Kumar   +6 more
doaj   +1 more source

TetR hybrid transcription factors report cell signaling and are inhibited by doxycycline

BioTechniques, 2005
We developed a bigenic reporter system composed of a hybrid transcription factor that combines the regulatory and activation domains of either Elk-1 or cyclic AMP-responsive element binding protein (CREB) with the DNA binding, dimerization, and ...
Michael B. Keeley, Johanna Busch, Rajesh Singh, Ted Abel   +3 more
doaj   +1 more source

A Novel Small-Molecule Inhibitor Targeting CREB-CBP Complex Possesses Anti-Cancer Effects along with Cell Cycle Regulation, Autophagy Suppression and Endoplasmic Reticulum Stress. [PDF]

PLoS ONE, 2015
Lung adenocarcinoma, the most common subtype of lung cancer, is the leading cause of cancer death worldwide. Despite attempts for the treatment of lung cancer which have been accumulating, promising new therapies are still needed.
Jong Woo Lee, Hee Sun Park, Sin-Aye Park, Seung-Hee Ryu, Wuyi Meng, Juliane M Jürgensmeier, Jonathan M Kurie, Waun Ki Hong, Julie L Boyer, Roy S Herbst, Ja Seok Koo   +10 more
doaj   +1 more source

Expression cloning of a zinc-finger cyclic AMP-response-element-binding protein [PDF]

Biochemical Journal, 1995
In response to specific extracellular signals, intracellular cyclic AMP levels increase, leading to a variety of responses including the alteration of transcription of many eukaryotic genes. This transcriptional effect is frequently mediated through the cyclic AMP-response element (CRE) motif T(T/G)ACGTCA. Using an expression screening approach we have
R M, O'Brien, N, Halmi, P E, Stromstedt, R L, Printz, D K, Granner   +4 more
openaire   +2 more sources

CREB Regulates AChE-R-Induced Proliferation of Human Glioblastoma Cells

Neoplasia: An International Journal for Oncology Research, 2004
The cyclic adenosine monophosphate (AMP) response element-binding protein, CREB, often modulates stress responses. Here, we report that CREB suppresses the glioblastoma proliferative effect of the stress-induced acetylcholinesterase variant, AChE-R.
Chava Perry, Ella H. Sklan, Hermona Soreq   +2 more
doaj   +1 more source

The Role of the CREB Protein Family Members and the Related Transcription Factors in Radioresistance Mechanisms

Life, 2021
In the framework of space flight, the risk of radiation carcinogenesis is considered a “red” risk due to the high likelihood of occurrence as well as the high potential impact on the quality of life in terms of disease-free survival after space missions.
Gianmarco Stati, Francesca Passaretta, Florelle Gindraux, Lucia Centurione, Roberta Di Pietro   +4 more
doaj   +1 more source

Airway epithelial cGAS inhibits LPS-induced acute lung injury through CREB signaling

Cell Death and Disease, 2023
Increased levels of cytosolic DNA in lung tissues play an important role in acute lung injury. However, the detailed mechanisms involved remain elusive.
Zhangchu Jin, Zhehua Shao, Shiyi Yang, Anyi Guo, Yinling Han, Yinfang Wu, Yun Zhao, Yanping Wu, Jiaxin Shen, Min Zhang, Xueqin Zhan, Wenqi Diao, Songmin Ying, Chao Zhang, Wen Li, Huahao Shen, Zhihua Chen, Fugui Yan   +17 more
doaj   +1 more source

Dual Mechanisms for Balancing Th17 and Treg Cell Fate by CREB

EBioMedicine, 2017
Th17 cells, which express the cytokine IL-17A, and master regulator RORγt, are important in the inflammatory response to fungal and bacterial pathogens, but also have a pathogenic role in many inflammatory disorders. In contrast, regulatory T cells (Treg)
Antony Symons, Wenjun Ouyang
doaj   +1 more source