Expression cloning of a zinc-finger cyclic AMP-response-element-binding protein [PDF]
Biochemical Journal, 1995 In response to specific extracellular signals, intracellular cyclic AMP levels increase, leading to a variety of responses including the alteration of transcription of many eukaryotic genes. This transcriptional effect is frequently mediated through the cyclic AMP-response element (CRE) motif T(T/G)ACGTCA. Using an expression screening approach we have
Richard M. O’Brien +4 more
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Regulation of cyclic AMP response element‐binding protein during neuroglial interactions [PDF]
Journal of Neurochemistry, 2015 AbstractCommunications between neurons and glial cells play an important role in regulating homeostasis in the central nervous system. cAMP response element‐binding protein (CREB), a transcription factor, is down‐regulated by neurotoxins, which are known to be released by activated glial cells.
Limei Qin +2 more
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DNA Replication Stress-induced Phosphorylation of Cyclic AMP Response Element-binding Protein Mediated by ATM [PDF]
Journal of Biological Chemistry, 2005 The DNA damage-response regulators ATM (ataxia-telangiectasia-mutated) and ATR (ATM-Rad3-related) are structurally and functionally related protein kinases that exhibit nearly identical substrate specificities in vitro. Current paradigms hold that the relative contributions of ATM and ATR to nuclear substrate phosphorylation are dictated by the type of
Gerald E. Dodson, Randal S. Tibbetts
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Minocycline upregulates cyclic AMP response element binding protein and brain-derived neurotrophic factor in the hippocampus of cerebral ischemia rats and improves behavioral deficits. [PDF]
Neuropsychiatr Dis Treat, 2015 Zhao Y, Xiao M, He W, Cai Z.
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Role of cyclic AMP response element-binding protein in cyclic AMP inhibition of NF-kappaB-mediated transcription. [PDF]
The Journal of Immunology, 1997 Abstract The NF-kappaB family of transcription factors regulates the inducible expression of a variety of genes. Recently, we showed that elevation of intracellular cyclic AMP inhibits NF-kappaB-mediated transcription in human monocytes and endothelial cells without preventing nuclear translocation of NF-kappaB complexes.
Graham C. Parry, Nigel Mackman
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Amitriptyline inhibits the MAPK/ERK and CREB pathways and proinflammatory cytokines through A3AR activation in rat neuropathic pain models [PDF]
Korean Journal of Anesthesiology, 2019 Background The pain-relief properties of tricyclic antidepressants can be attributed to several actions. Recent observations suggest that adenosine is involved in the antinociceptive effect of amitriptyline.
Yumi Kim +8 more
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Conserved and distinct modes of CREB/ATF transcription factor regulation by PP2A/B56gamma and genotoxic stress. [PDF]
PLoS ONE, 2010 Activating transcription factor 1 (ATF1) and the closely related proteins CREB (cyclic AMP resonse element binding protein) and CREM (cyclic AMP response element modulator) constitute a subfamily of bZIP transcription factors that play critical roles in ...
Naval P Shanware +5 more
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Experimental Hematology & Oncology, 2022 Background The protein kinase A (PKA)/cAMP response element-binding protein (CREB) has been suggested to be related to the inhibition of the proliferation of non-small cell lung cancer (NSCLC) cells.
Jae Heun Chung +14 more
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Role of cyclic AMP response element binding protein in human leukemias [PDF]
Cancer, 2005 AbstractAcute myeloid leukemia (AML) in adults has a 20% 5‐year disease‐free survival despite treatment with aggressive cytotoxic chemotherapy. Previous work from our laboratory demonstrated that the majority of patients with acute lymphoid and myeloid leukemia overexpress CREB in the bone marrow.
Deepa Shankar +2 more
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JCI Insight, 2021 Obesity, a major health care issue, is characterized by metabolic abnormalities in multiple tissues, including the skeletal muscle. Although dysregulation of skeletal muscle metabolism can strongly influence the homeostasis of systemic energy, the ...
Bo Xu +9 more
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