Results 31 to 40 of about 32,383 (302)
Down-regulation of the histone methyltransferase EZH2 contributes to the epigenetic programming of decidualizing human endometrial stromal cells [PDF]
, 2011 Differentiation of human endometrial stromal cells (HESC) into decidual cells represents a highly coordinated process essential for embryo implantation. We show that decidualizing HESC down-regulate the histone methyltransferase enhancer of Zeste homolog
Poutanen, Matti +14 more
core +1 more source
Dual Mechanisms for Balancing Th17 and Treg Cell Fate by CREB
EBioMedicine, 2017 Th17 cells, which express the cytokine IL-17A, and master regulator RORγt, are important in the inflammatory response to fungal and bacterial pathogens, but also have a pathogenic role in many inflammatory disorders. In contrast, regulatory T cells (Treg)
Antony Symons, Wenjun Ouyang
doaj +1 more source
Ending Restenosis: Inhibition of Vascular Smooth Muscle Cell Proliferation by cAMP
Cells, 2019 Increased vascular smooth muscle cell (VSMC) proliferation contributes towards restenosis after angioplasty, vein graft intimal thickening and atherogenesis.
Sarah A. Smith +2 more
doaj +1 more source
Cyclic AMP signalling in pancreatic islets
, 2010 Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet β-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in ...
Nigel J. Pyne +7 more
core +1 more source
Dementia and Geriatric Cognitive Disorders Extra, 2013 Objective: To study the relationship of the expression of phosphorylated cyclic AMP response element-binding protein (pCREB) and early growth response protein 1 (Egr1) in the hippocampus of aged mice with retrieval of consolidated spatial memory in a ...
GuoXia Zhou +3 more
doaj +1 more source
The amino terminus of Tax is required for interaction with the cyclic AMP response element binding protein [PDF]
Journal of Virology, 1995 Tax of human T-cell leukemia virus type 1 was analyzed for interaction with the cyclic AMP response element binding protein (CREB) in vitro with and without Tax response element DNA. Mutations in the carboxy terminus of Tax (L296G and L320G) did not affect binding to CREB and led to supershifts.
I, Goren +3 more
openaire +2 more sources
From Drosophila development to adult: clues to Notch function in long-term memory
Frontiers in Cellular Neuroscience, 2013 Notch is a cell surface receptor that is well known to mediate inter-cellular communication during animal development. Data in the field indicate that it is also involved in the formation of long-term memory (LTM) in the fully developed adults and in ...
Jiabin eZhang +2 more
doaj +1 more source
Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells [PDF]
, 2014 The insulin/IGF-1 (insulin-like growth factor 1)-activated protein kinase Akt (also known as protein kinase B) phosphorylates Ser487 in the ‘ST loop’ (serine/threonine-rich loop) within the C-terminal domain of AMPK-a1 (AMP-activated protein kinase-a1 ...
Leslie, Nicholas R. +6 more
core +1 more source
Basic and Clinical Neuroscience, 2021 Introduction: The neuroprotective impact of curcumin and the role of CREB (Cyclic AMP Response Element Binding protein)-BDNF (Brain-Derived Neurotrophic Factor) signaling pathway was evaluated in Methamphetamine (METH)-induced neurodegeneration in rats ...
Mina Gholami +6 more
doaj
Global conformational selection and local induced fit for the recognition between intrinsic disordered p53 and CBP. [PDF]
PLoS ONE, 2013 The transactivation domain (TAD) of tumor suppressor p53 can bind with the nuclear coactivator binding domain (NCBD) of cyclic-AMP response element binding protein (CBP) and activate transcription.
Qingfen Yu +3 more
doaj +1 more source