Results 31 to 40 of about 64,980 (302)

Dual Mechanisms for Balancing Th17 and Treg Cell Fate by CREB

EBioMedicine, 2017
Th17 cells, which express the cytokine IL-17A, and master regulator RORγt, are important in the inflammatory response to fungal and bacterial pathogens, but also have a pathogenic role in many inflammatory disorders. In contrast, regulatory T cells (Treg)
Antony Symons, Wenjun Ouyang
doaj   +1 more source

Porcine oocyte maturation in vitro : role of cAMP and oocyte-secreted factors: a practical approach [PDF]

, 2016
Polyspermy or the penetration of more than one sperm cell remains a problem during porcine in vitro fertilization (IVF). After in vitro culture of porcine zygotes, only a low percentage of blastocysts develop and their quality is inferior to that of in ...
Appeltant, Ruth, Kikuchi, Kazuhiro, Maes, Dominiek, Somfai, Tamás, Van Soom, Ann   +4 more
core   +2 more sources

Ending Restenosis: Inhibition of Vascular Smooth Muscle Cell Proliferation by cAMP

Cells, 2019
Increased vascular smooth muscle cell (VSMC) proliferation contributes towards restenosis after angioplasty, vein graft intimal thickening and atherogenesis.
Sarah A. Smith, Andrew C. Newby, Mark Bond   +2 more
doaj   +1 more source

STING-dependent recognition of cyclic di-AMP mediates type I interferon responses during Chlamydia trachomatis infection. [PDF]

, 2013
UnlabelledSTING (stimulator of interferon [IFN] genes) initiates type I IFN responses in mammalian cells through the detection of microbial nucleic acids. The membrane-bound obligate intracellular bacterium Chlamydia trachomatis induces a STING-dependent
Barker, Jeffrey R, Burdette, Dara L, Carpenter, Victoria K, Koestler, Benjamin J, Valdivia, Raphael H, Vance, Russell E, Waters, Christopher M   +6 more
core   +2 more sources

Retrieval of Consolidated Spatial Memory in the Water Maze Is Correlated with Expression of pCREB and Egr1 in the Hippocampus of Aged Mice

Dementia and Geriatric Cognitive Disorders Extra, 2013
Objective: To study the relationship of the expression of phosphorylated cyclic AMP response element-binding protein (pCREB) and early growth response protein 1 (Egr1) in the hippocampus of aged mice with retrieval of consolidated spatial memory in a ...
GuoXia Zhou, WanXia Xiong, XiaoGuang Zhang, ShengJin Ge   +3 more
doaj   +1 more source

Nuclear expression of PG-21, SRC-1, and pCREB in regions of the lumbosacral spinal cord involved in pelvic innervation in young adult and aged rats [PDF]

, 2012
In rats, ageing results in dysfunctional patterns of micturition and diminished sexual reflexes that may reflect degenerative changes within spinal circuitry.
Amandusson, Anderson, Balazs, Berkley, Blanchet, Blanco, Blok, Breedlove, Breedlove, Burke, Chambers, Chambers, Collins, Dail, Davidson, De Cesare, Dering, Dering, Eika, Ernfors, Fargo, Ferrini, Finkbeiner, Frankel, Fraser, Ghanadian, Giuliano, Goldstein, Goldstein, Gonzalez, Gray, Gréco, Hancock, Hodges, Holmes, Hsu, Johnson, Jordan, Jordan, Jordan, Kepper, Kurz, Labombarda, Leo, Leslie, Lubischer, Marson, Marson, Marson, Marson, Marson, Matsumoto, Matsumoto, Matsumoto, Matsumoto, Matsumoto, Matsumoto, Mattson, Mayr, McKenna, McKenna, McManus, Meisel, Monks, Monks, Montminy, Nadelhaft, Nadelhaft, Nadelhaft, Nicolopoulos-Stournaras, Nordeen, O'Bryant, Osborne, Papka, Papka, Papka, Papka, Papka, Purinton, Ranson, Ranson, Ranson, Ranson, Ranson, Ranson, Reichardt, Santer, Schrøder, Sengelaub, Shibata, Smith, Smith, Tan, Tang, Tobin, Ulfhake, VanderHorst, Vera, Watkins, Watson, Williams, Wu, Wu, Yaici, Yamamoto, Yan, Yang, Yang, Yaïci   +108 more
core   +1 more source

From Drosophila development to adult: clues to Notch function in long-term memory

Frontiers in Cellular Neuroscience, 2013
Notch is a cell surface receptor that is well known to mediate inter-cellular communication during animal development. Data in the field indicate that it is also involved in the formation of long-term memory (LTM) in the fully developed adults and in ...
Jiabin eZhang, Jerry eYin, Cedric S Wesley   +2 more
doaj   +1 more source

Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels [PDF]

, 2007
Disrupted-in-schizophrenia 1 (DISC1) is a genetic susceptibility factor for schizophrenia and related severe psychiatric conditions. DISC1 is a multifunctional scaffold protein that is able to interact with several proteins, including the independently ...
Bolger, G.B., Collins, D.M., Hill, E.V., Houslay, M.D., Klussmann, E., Mackie, S., Millar, J.K., Murdoch, H., Porteous, D.J.   +8 more
core   +1 more source

Pharmacological and Molecular Evidence of Neuroprotective Curcumin Effects Against Biochemical and Behavioral Sequels Caused by Methamphetamine: Possible Function of CREB-BDNF Signaling Pathway

Basic and Clinical Neuroscience, 2021
Introduction: The neuroprotective impact of curcumin and the role of CREB (Cyclic AMP Response Element Binding protein)-BDNF (Brain-Derived Neurotrophic Factor) signaling pathway was evaluated in Methamphetamine (METH)-induced neurodegeneration in rats ...
Mina Gholami, Farzad Hozuri, Setayesh Abdolkarimi, Mahsa Mahmoudi, Majid Motaghinejad, Sepideh Safari, Samira Sadr   +6 more
doaj  

Global conformational selection and local induced fit for the recognition between intrinsic disordered p53 and CBP. [PDF]

PLoS ONE, 2013
The transactivation domain (TAD) of tumor suppressor p53 can bind with the nuclear coactivator binding domain (NCBD) of cyclic-AMP response element binding protein (CBP) and activate transcription.
Qingfen Yu, Wei Ye, Wei Wang, Hai-Feng Chen   +3 more
doaj   +1 more source