Results 11 to 20 of about 12,173,403 (296)
Neuropsychiatric Disease and Treatment, 2015 Yu Zhao,1 Ming Xiao,2 Wenbo He,3 Zhiyou Cai3 1Department of Neurology, the Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, People’s Republic of China; 2Department of Anatomy, Nanjing Medical ...
Zhao Y, Xiao M, He W, Cai Z
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Cyclic AMP signalling in pancreatic islets [PDF]
, 2010 Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet β-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in ...
Pyne, Nigel J. +2 more
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Cyclic AMP Response Element-Binding Protein in the Vessel Wall [PDF]
Circulation, 2003 Atherosclerosis and postangioplasty restenosis are leading causes of death in the Western world. Recent advances in our understanding of vascular biology would suggest that targeting specific signals in the post–balloon injury vessel or in persons prone to development of atherosclerosis could decrease lesion formation and in the long term decrease ...
Jane E.B. Reusch, Dwight J. Klemm
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Cell Reports, 2023 Summary: Remyelination after white matter injury (WMI) often fails in diseases such as multiple sclerosis because of improper recruitment and repopulation of oligodendrocyte precursor cells (OPCs) in lesions.
Kimberly K. Hoi +7 more
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Role of cyclic AMP in the control of cell-specific gene expression [PDF]
, 1993 Genes have to be expressed in specific cell types at appropriate times of development dependent on external signals. cAMP signaling occurs in all cells, thus raising the question of how this signal transduction pattern is integrated into mechanisms ...
Boshart, Michael +3 more
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Resveratrol inhibits LPS-induced MAPKs activation via activation of the phosphatidylinositol 3-kinase pathway in murine RAW 264.7 macrophage cells. [PDF]
PLoS ONE, 2012 BACKGROUND: Resveratrol is a natural polyphenolic compound that has cardioprotective, anticancer and anti-inflammatory properties. We investigated the capacity of resveratrol to protect RAW 264.7 cells from inflammatory insults and explored mechanisms ...
Yi Zong +10 more
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Neoplasia: An International Journal for Oncology Research, 2007 We recently showed that NexrutineR, a Phellodendron amurense bark extract, suppresses proliferation of prostate cancer cell lines and tumor development in the transgenic adenocarcinoma of mouse prostate (TRAMP) model.
Rita Ghosh +6 more
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Expression cloning of a zinc-finger cyclic AMP-response-element-binding protein [PDF]
Biochemical Journal, 1995 In response to specific extracellular signals, intracellular cyclic AMP levels increase, leading to a variety of responses including the alteration of transcription of many eukaryotic genes. This transcriptional effect is frequently mediated through the cyclic AMP-response element (CRE) motif T(T/G)ACGTCA. Using an expression screening approach we have
R M, O'Brien +4 more
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TetR hybrid transcription factors report cell signaling and are inhibited by doxycycline
BioTechniques, 2005 We developed a bigenic reporter system composed of a hybrid transcription factor that combines the regulatory and activation domains of either Elk-1 or cyclic AMP-responsive element binding protein (CREB) with the DNA binding, dimerization, and ...
Michael B. Keeley +3 more
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A Novel Small-Molecule Inhibitor Targeting CREB-CBP Complex Possesses Anti-Cancer Effects along with Cell Cycle Regulation, Autophagy Suppression and Endoplasmic Reticulum Stress. [PDF]
PLoS ONE, 2015 Lung adenocarcinoma, the most common subtype of lung cancer, is the leading cause of cancer death worldwide. Despite attempts for the treatment of lung cancer which have been accumulating, promising new therapies are still needed.
Jong Woo Lee +10 more
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