Results 11 to 20 of about 64,980 (302)

PI3Kγ (Phosphoinositide 3-Kinase γ) Regulates Vascular Smooth Muscle Cell Phenotypic Modulation and Neointimal Formation Through CREB (Cyclic AMP-Response Element Binding Protein)/YAP (Yes-Associated Protein) Signaling. [PDF]

Arterioscler Thromb Vasc Biol, 2019
Yu Q, Li W, Jin R, Yu S, Xie D, Zheng X, Zhong W, Cheng X, Hu S, Li M, Zheng Q, Li G, Song Z.   +12 more
europepmc   +2 more sources

Primary cilia control oligodendrocyte precursor cell proliferation in white matter injury via Hedgehog-independent CREB signaling

Cell Reports, 2023
Summary: Remyelination after white matter injury (WMI) often fails in diseases such as multiple sclerosis because of improper recruitment and repopulation of oligodendrocyte precursor cells (OPCs) in lesions.
Kimberly K. Hoi, Wenlong Xia, Ming Ming Wei, Maria Jose Ulloa Navas, Jose-Manuel Garcia Verdugo, Maxence V. Nachury, Jeremy F. Reiter, Stephen P.J. Fancy   +7 more
doaj   +1 more source

Galectin-12 in Cellular Differentiation, Apoptosis and Polarization. [PDF]

, 2018
Galectin-12 is a member of a family of mammalian lectins characterized by their affinity for β-galactosides and consensus amino acid sequences. The protein structure consists of a single polypeptide chain containing two carbohydrate-recognition domains ...
Liu, Fu-Tong, Wan, Lei, Yang, Ri-Yao
core   +2 more sources

Resveratrol inhibits LPS-induced MAPKs activation via activation of the phosphatidylinositol 3-kinase pathway in murine RAW 264.7 macrophage cells. [PDF]

PLoS ONE, 2012
BACKGROUND: Resveratrol is a natural polyphenolic compound that has cardioprotective, anticancer and anti-inflammatory properties. We investigated the capacity of resveratrol to protect RAW 264.7 cells from inflammatory insults and explored mechanisms ...
Yi Zong, Lin Sun, Bin Liu, Yi-Shu Deng, Dong Zhan, Yuan-Li Chen, Ying He, Jing Liu, Zong-Ji Zhang, Jun Sun, Di Lu   +10 more
doaj   +1 more source

Bacillus anthracis edema factor substrate specificity: evidence for new modes of action [PDF]

, 2012
Since the isolation of Bacillus anthracis exotoxins in the 1960s, the detrimental activity of edema factor (EF) was considered as adenylyl cyclase activity only.
Agrawal, Altaweel, Basler, Bauche, Bell, Benson, Beste, Bock, Bond, Boyd, Bradley, Brown, Burhenne, Carbonetti, Carbonetti, Carson-Walter, Casteel, Christensen, Christensen, Confer, Copsel, Crawford, Crowe, Cunningham, Dalkas, Defer, Deuquet, Ding, Drum, Duesbery, Feld, Firoved, Friedlander, Fu, Fukuhara, Gaion, Gille, Gordon, Göttle, Hammerschmidt, He, Helfman, Hong, Ivarsson, Jernigan, Johnson, Katayama, Katayama, Kaupp, Kintzer, Klimpel, Laine, Larabee, Larabee, Leppla, Liu, Martin Göttle, McDonough, Milne, Mogridge, Mogridge, Newton, Newton, Newton, Newton, Newton, Oncu, O´Brien, Park, Petosa, Pezard, Postea, Puhar, Roland Seifert, Santelli, Scobie, Scobie, Scorpio, Shapiro, Shen, Shirshev, Soelaiman, Stefan Dove, Sun, Tamayo, Taylor, Taylor, Tesmer, Thomas, Tournier, Vitale, Vitale, Vojtova, Yeager, Zong   +94 more
core   +2 more sources

Cyclic AMP Response Element-Binding Protein in the Vessel Wall [PDF]

Circulation, 2003
Atherosclerosis and postangioplasty restenosis are leading causes of death in the Western world. Recent advances in our understanding of vascular biology would suggest that targeting specific signals in the post–balloon injury vessel or in persons prone to development of atherosclerosis could decrease lesion formation and in the long term decrease ...
Jane E.B. Reusch, Dwight J. Klemm
openaire   +1 more source

Cyclic AMP response element binding protein CREB and modulator protein CREM are products of distinct genes

Nucleic Acids Research, 1992
T E, Meyer, J F, Habener
openaire   +5 more sources

Regulation of Cox-2 by Cyclic AMP Response Element Binding Protein in Prostate Cancer: Potential Role for Nexrutine

Neoplasia: An International Journal for Oncology Research, 2007
We recently showed that NexrutineR, a Phellodendron amurense bark extract, suppresses proliferation of prostate cancer cell lines and tumor development in the transgenic adenocarcinoma of mouse prostate (TRAMP) model.
Rita Ghosh, Gretchen E. Garcia, Katherine Crosby, Hiroyasu Inoue, Ian M. Thompson, Dean A. Troyer, Addanki P. Kumar   +6 more
doaj   +1 more source

Expression cloning of a zinc-finger cyclic AMP-response-element-binding protein [PDF]

Biochemical Journal, 1995
In response to specific extracellular signals, intracellular cyclic AMP levels increase, leading to a variety of responses including the alteration of transcription of many eukaryotic genes. This transcriptional effect is frequently mediated through the cyclic AMP-response element (CRE) motif T(T/G)ACGTCA. Using an expression screening approach we have
R M, O'Brien, N, Halmi, P E, Stromstedt, R L, Printz, D K, Granner   +4 more
openaire   +2 more sources

TetR hybrid transcription factors report cell signaling and are inhibited by doxycycline

BioTechniques, 2005
We developed a bigenic reporter system composed of a hybrid transcription factor that combines the regulatory and activation domains of either Elk-1 or cyclic AMP-responsive element binding protein (CREB) with the DNA binding, dimerization, and ...
Michael B. Keeley, Johanna Busch, Rajesh Singh, Ted Abel   +3 more
doaj   +1 more source