Results 21 to 30 of about 32,383 (302)

TetR hybrid transcription factors report cell signaling and are inhibited by doxycycline

BioTechniques, 2005
We developed a bigenic reporter system composed of a hybrid transcription factor that combines the regulatory and activation domains of either Elk-1 or cyclic AMP-responsive element binding protein (CREB) with the DNA binding, dimerization, and ...
Michael B. Keeley, Johanna Busch, Rajesh Singh, Ted Abel   +3 more
doaj   +1 more source

A Novel Small-Molecule Inhibitor Targeting CREB-CBP Complex Possesses Anti-Cancer Effects along with Cell Cycle Regulation, Autophagy Suppression and Endoplasmic Reticulum Stress. [PDF]

PLoS ONE, 2015
Lung adenocarcinoma, the most common subtype of lung cancer, is the leading cause of cancer death worldwide. Despite attempts for the treatment of lung cancer which have been accumulating, promising new therapies are still needed.
Jong Woo Lee, Hee Sun Park, Sin-Aye Park, Seung-Hee Ryu, Wuyi Meng, Juliane M Jürgensmeier, Jonathan M Kurie, Waun Ki Hong, Julie L Boyer, Roy S Herbst, Ja Seok Koo   +10 more
doaj   +1 more source

The cGMP-dependent protein kinase II Is an inhibitory modulator of the hyperpolarization-activated HCN2 channel [PDF]

, 2011
Opening of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels is facilitated by direct binding of cyclic nucleotides to a cyclic nucleotide-binding domain (CNBD) in the C-terminus. Here, we show for the first time that in the HCN2 channel
Biel Martin, Biel, Martin, Hammelmann, Verena, Hofmann, Franz, Michalakis, Stylianos, Xiangang Zong, Hammelmann Verena, Zong Xiangang, Stylianos Michalakis, Martin Biel, Franz Hofmann, Michalakis Stylianos, Hofmann Franz, Zong, Xiangang, Verena Hammelmann   +14 more
core   +1 more source

The Role of the CREB Protein Family Members and the Related Transcription Factors in Radioresistance Mechanisms

Life, 2021
In the framework of space flight, the risk of radiation carcinogenesis is considered a “red” risk due to the high likelihood of occurrence as well as the high potential impact on the quality of life in terms of disease-free survival after space missions.
Gianmarco Stati, Francesca Passaretta, Florelle Gindraux, Lucia Centurione, Roberta Di Pietro   +4 more
doaj   +1 more source

Crossroads between drug and energy metabolism : role of constitutive androstane receptor and AMP-activated kinase [PDF]

, 2010
Phenobarbital (PB) is a prototype inducer of genes encoding drug metabolizing enzymes including the cytochromes P450 (CYPs). Additionally, phenobarbital was found to repress genes that encode enzymes involved in gluconeogenesis such as ...
Harach, Taoufiq
core   +1 more source

G9a inhibits CREB-triggered expression of mu opioid receptor in primary sensory neurons following peripheral nerve injury

Molecular Pain, 2016
Neuropathic pain, a distressing and debilitating disorder, is still poorly managed in clinic. Opioids, like morphine, remain the mainstay of prescribed medications in the treatment of this disorder, but their analgesic effects are highly unsatisfactory ...
Lingli Liang MD, PhD, Jian-Yuan Zhao PhD, Xiyao Gu PhD, Shaogen Wu MD, PhD, Kai Mo MD, PhD, Ming Xiong MD, PhD, Brianna Marie Lutz BS, Alex Bekker MD, PhD, Yuan-Xiang Tao MD, PhD   +8 more
doaj   +1 more source

CREB Regulates AChE-R-Induced Proliferation of Human Glioblastoma Cells

Neoplasia: An International Journal for Oncology Research, 2004
The cyclic adenosine monophosphate (AMP) response element-binding protein, CREB, often modulates stress responses. Here, we report that CREB suppresses the glioblastoma proliferative effect of the stress-induced acetylcholinesterase variant, AChE-R.
Chava Perry, Ella H. Sklan, Hermona Soreq   +2 more
doaj   +1 more source

Cyclic AMP increases COX-2 expression via mitogen-activated kinase in human myometrial cells [PDF]

, 2011
Cyclic AMP (cAMP) is the archetypal smooth muscle relaxant, mediating the effects of many hormones and drugs. However, recently PGI2, acting via cAMP/PKA, was found to increase contraction-associated protein expression in myometrial cells and to promote ...
Mandeep Kandola, Mark R. Johnson, Kandola, Mandeep, Zhiqing Liang, Johnson, Mark R., Chen, Li, Lei, Kaiyu, Sooranna, Suren R, Phillip R. Bennett, Dimitri Grammatopoulos, Grammatopoulos, Dimitris, Bennett, Phillip, Johnson, Mark R, Suren R. Sooranna, Chen, Li I., Li Chen, Kaiyu Lei, Sooranna, Suren R., Grammatopoulos, Dimitri, Liang, Zhiqing, Bennett, Phillip R   +20 more
core   +1 more source

Airway epithelial cGAS inhibits LPS-induced acute lung injury through CREB signaling

Cell Death and Disease, 2023
Increased levels of cytosolic DNA in lung tissues play an important role in acute lung injury. However, the detailed mechanisms involved remain elusive.
Zhangchu Jin, Zhehua Shao, Shiyi Yang, Anyi Guo, Yinling Han, Yinfang Wu, Yun Zhao, Yanping Wu, Jiaxin Shen, Min Zhang, Xueqin Zhan, Wenqi Diao, Songmin Ying, Chao Zhang, Wen Li, Huahao Shen, Zhihua Chen, Fugui Yan   +17 more
doaj   +1 more source

Analysis of cyclic di-GMP signaling components in "caulobacter crescentus" behavior and cell cycle control [PDF]

, 2013
Cell cycle progression and polar morphogenesis in Caulobacter crescentus are coordinated by the interplay of multiple proteins in time and space. One major regulatory factor is the second messenger cyclic di-GMP (c-di-GMP) therefore especially the ...
Friedrich, Elvira
core   +1 more source