Results 41 to 50 of about 32,383 (302)

Fic-mediated adenylylation : catalysis and regulation [PDF]

, 2014
Adenylylation, also referred to as adenylation or AMPylation, is the process by which adenosine-5‘-monophosphate (AMP) is covalently attached to a protein, a nucleic acid, or a small molecule.
Goepfert, Arnaud
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

The Circular RNA Circ_0043947 Promoted Gastric Cancer Progression by Sponging miR-384 to Regulate CREB1 Expression

Gut and Liver
Background/Aims: The occurrence and development of circular RNAs in gastric cancer (GC) has attracted increasing attention. This study focused on investigating the biological role and molecular mechanism of circ_0043947 in GC.
Chongxin Zhang, Fan Zhang, Yukun Li, Pengfei Yang, Yang Liu, Wenxiao Yang   +5 more
doaj   +1 more source

Genetic alteration of anxiety and stress-like behavior in mice lacking CaMKIV

Molecular Pain, 2005
Calcium-calmodulin-dependent protein kinase IV (CaMKIV) phosphorylates the major transcription factor cyclic AMP-response element binding protein (CREB), which plays a role in emotional behavior.
Kaang Bong-Kiun, Lee Yong-Seok, Ko Shanelle W, Shum Fanny WF, Zhuo Min   +4 more
doaj   +1 more source

Dysregulation in the Unfolded Protein Response in the FGR Rat Pancreas

International Journal of Endocrinology, 2020
Accumulating evidence suggests that fetal growth restriction (FGR) leads to the development of diabetes mellitus in adults. The aim of this study was to investigate the effect of protein malnutrition in utero on the pancreatic unfolded protein response ...
Xiaomei Liu, Yanyan Guo, Jun Wang, Liangliang Zhu, Linlin Gao   +4 more
doaj   +1 more source

Epigenetically modulated miR-1224 suppresses the proliferation of HCC through CREB-mediated activation of YAP signaling pathway

Molecular Therapy: Nucleic Acids, 2021
Mounting evidence has demonstrated that microRNA-1224 (miR-1224) is commonly downregulated and serves as a tumor suppressor in multiple malignancies.
Shikun Yang, Wei Jiang, Wenjie Yang, Chao Yang, Xinchen Yang, Keyan Chen, Yuanchang Hu, Gefenqiang Shen, Ling Lu, Feng Cheng, Feng Zhang, Jianhua Rao, Xuehao Wang   +12 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Cyclic AMP response element binding protein (CREB) regulation by asbestos

The FASEB Journal, 2007
Inhalation of asbestos fibers has been associated with the development of lung cancers and mesotheliomas. Little is known about the crucial cellular mechanisms that initiate and drive the processes of carcinogenesis. Because CREs (Ca 2+ /cAMP response elements) are found in the promoters of ...
Arti Shukla, Trisha F Barrett, Christy A Barlow, Karen M Lounsbury, Brooke T Mossman   +4 more
openaire   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source