Results 51 to 60 of about 32,383 (302)

7-Pyrrolidinethoxy-4′-Methoxyisoflavone Prevents Amyloid β–Induced Injury by Regulating Histamine H3 Receptor-Mediated cAMP/CREB and AKT/GSK3β Pathways

Frontiers in Neuroscience, 2019
In studies on the treatment of Alzheimer’s disease (AD), in which cognition is enhanced even modestly or selectively, it has been considered that the histamine H3 receptor (H3R) may be a potential target. In this study, we aimed at evaluating the ability
Linlin Wang, Linlin Wang, Jiansong Fang, Hailun Jiang, Qian Wang, Situ Xue, Zhuorong Li, Rui Liu   +7 more
doaj   +1 more source

The Rapid and Long-Lasting Antidepressant Effects of Iridoid Fraction in Gardenia Jasminoides J.Ellis Are Dependent on Activating PKA-CREB Signaling Pathway

Frontiers in Pharmacology, 2022
Lag periods of therapeutic efficacy cause poor compliance of patients, which has made solutions for rapid antidepressants the most urgent need in the depression study field at present.
Li Ren, Hailou Zhang, Weiwei Tao, Yin Chen, Zhilu Zou, XiaoYan Guo, Qinqin Shen, Quansheng Feng, Jingqing Hu   +8 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

The 'scavenger' m(7)GpppX pyrophosphatase activity of Dcs1 modulates nutrient-induced responses in yeast [PDF]

, 2004
Dcs1, the m(7)GpppX pyrophosphatase of Saccharomyces cerevisiae, has been reported to 'scavenge' capped 51 end fragments generated by 3'-->5' mRNA degradation.
Miyan, J, Tollervey, D, McCarthy, J E G, McCarthy, John E G, Carroll, K, Carroll, Kathleen; id_orcid, Malys, N, Tollervey, David, Mccarthy, John, Malys, Naglis, Miyan, Jaleel; id_orcid   +10 more
core   +1 more source

Molecular Determinants of the Spacing Effect

Neural Plasticity, 2012
Long-term memory formation is sensitive to the pattern of training sessions. Training distributed over time (spaced training) is superior at generating long-term memories than training presented with little or no rest interval (massed training).
Faisal Naqib, Wayne S. Sossin, Carole A. Farah   +2 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Exogenous NAD⁺ Stimulates MUC2 Expression in LS 174T Goblet Cells via the PLC-Delta/PTGES/PKC-Delta/ERK/CREB Signaling Pathway

Biomolecules, 2020
Background: MUC2, a major component of the mucus layer in the intestine, is associated with antimicrobial activity and gut immune system function. Currently, mucin is mainly known for its critical function in defense against toxic molecules and pathogens.
Seongho Ma, Jiah Yeom, Young-Hee Lim
doaj   +1 more source

Systematical analysis reveals a strong cancer relevance of CREB1-regulated genes

Cancer Cell International, 2021
The transcription factor cyclic-AMP response element-binding protein 1 (CREB1) responds to cAMP level and controls the expression of target genes, which regulates nutrition partitioning.
Tianyu Zheng, Jinrong Huang, Xi Xiang, Siyuan Li, Jiaying Yu, Kunli Qu, Zhe Xu, Peng Han, Zhanying Dong, Yang Liu, Fengping Xu, Huanming Yang, Marja Jäättelä, Yonglun Luo, Bin Liu   +14 more
doaj   +1 more source

Growth Suppression of Lung Cancer Cells by Targeting Cyclic AMP Response Element-Binding Protein [PDF]

Cancer Research, 2008
Abstract Genes regulated by cyclic AMP–response element-binding protein (CREB) have been reported to suppress apoptosis, induce cell proliferation, and mediate inflammation and tumor metastasis. However, it is not clear whether CREB is critically involved in lung carcinogenesis. We found that non–small cell lung cancer (NSCLC) cell lines
Sita, Aggarwal, Seung-Wook, Kim, Seung-Hee, Ryu, Wen-Cheng, Chung, Ja Seok, Koo   +4 more
openaire   +2 more sources