Results 21 to 30 of about 30,015 (162)

Ending Restenosis: Inhibition of Vascular Smooth Muscle Cell Proliferation by cAMP

Cells, 2019
Increased vascular smooth muscle cell (VSMC) proliferation contributes towards restenosis after angioplasty, vein graft intimal thickening and atherogenesis.
Sarah A. Smith, Andrew C. Newby, Mark Bond   +2 more
doaj   +1 more source

Retrieval of Consolidated Spatial Memory in the Water Maze Is Correlated with Expression of pCREB and Egr1 in the Hippocampus of Aged Mice

Dementia and Geriatric Cognitive Disorders Extra, 2013
Objective: To study the relationship of the expression of phosphorylated cyclic AMP response element-binding protein (pCREB) and early growth response protein 1 (Egr1) in the hippocampus of aged mice with retrieval of consolidated spatial memory in a ...
GuoXia Zhou, WanXia Xiong, XiaoGuang Zhang, ShengJin Ge   +3 more
doaj   +1 more source

From Drosophila development to adult: clues to Notch function in long-term memory

Frontiers in Cellular Neuroscience, 2013
Notch is a cell surface receptor that is well known to mediate inter-cellular communication during animal development. Data in the field indicate that it is also involved in the formation of long-term memory (LTM) in the fully developed adults and in ...
Jiabin eZhang, Jerry eYin, Cedric S Wesley   +2 more
doaj   +1 more source

Pharmacological and Molecular Evidence of Neuroprotective Curcumin Effects Against Biochemical and Behavioral Sequels Caused by Methamphetamine: Possible Function of CREB-BDNF Signaling Pathway

Basic and Clinical Neuroscience, 2021
Introduction: The neuroprotective impact of curcumin and the role of CREB (Cyclic AMP Response Element Binding protein)-BDNF (Brain-Derived Neurotrophic Factor) signaling pathway was evaluated in Methamphetamine (METH)-induced neurodegeneration in rats ...
Mina Gholami, Farzad Hozuri, Setayesh Abdolkarimi, Mahsa Mahmoudi, Majid Motaghinejad, Sepideh Safari, Samira Sadr   +6 more
doaj  

Global conformational selection and local induced fit for the recognition between intrinsic disordered p53 and CBP. [PDF]

PLoS ONE, 2013
The transactivation domain (TAD) of tumor suppressor p53 can bind with the nuclear coactivator binding domain (NCBD) of cyclic-AMP response element binding protein (CBP) and activate transcription.
Qingfen Yu, Wei Ye, Wei Wang, Hai-Feng Chen   +3 more
doaj   +1 more source

The transcription factor cyclic AMP–responsive element–binding protein H regulates triglyceride metabolism [PDF]

Nature Medicine, 2011
Here we report that the transcription factor cyclic AMP-responsive element-binding protein H (CREB-H, encoded by CREB3L3) is required for the maintenance of normal plasma triglyceride concentrations. CREB-H-deficient mice showed hypertriglyceridemia secondary to inefficient triglyceride clearance catalyzed by lipoprotein lipase (Lpl), partly due to ...
Jung Hoon, Lee, Petros, Giannikopoulos, Stephen A, Duncan, Jian, Wang, Christopher T, Johansen, Jonathan D, Brown, Jorge, Plutzky, Robert A, Hegele, Laurie H, Glimcher, Ann-Hwee, Lee   +9 more
openaire   +2 more sources

The Circular RNA Circ_0043947 Promoted Gastric Cancer Progression by Sponging miR-384 to Regulate CREB1 Expression

Gut and Liver
Background/Aims: The occurrence and development of circular RNAs in gastric cancer (GC) has attracted increasing attention. This study focused on investigating the biological role and molecular mechanism of circ_0043947 in GC.
Chongxin Zhang, Fan Zhang, Yukun Li, Pengfei Yang, Yang Liu, Wenxiao Yang   +5 more
doaj   +1 more source

Genetic alteration of anxiety and stress-like behavior in mice lacking CaMKIV

Molecular Pain, 2005
Calcium-calmodulin-dependent protein kinase IV (CaMKIV) phosphorylates the major transcription factor cyclic AMP-response element binding protein (CREB), which plays a role in emotional behavior.
Kaang Bong-Kiun, Lee Yong-Seok, Ko Shanelle W, Shum Fanny WF, Zhuo Min   +4 more
doaj   +1 more source

Dysregulation in the Unfolded Protein Response in the FGR Rat Pancreas

International Journal of Endocrinology, 2020
Accumulating evidence suggests that fetal growth restriction (FGR) leads to the development of diabetes mellitus in adults. The aim of this study was to investigate the effect of protein malnutrition in utero on the pancreatic unfolded protein response ...
Xiaomei Liu, Yanyan Guo, Jun Wang, Liangliang Zhu, Linlin Gao   +4 more
doaj   +1 more source

Epigenetically modulated miR-1224 suppresses the proliferation of HCC through CREB-mediated activation of YAP signaling pathway

Molecular Therapy: Nucleic Acids, 2021
Mounting evidence has demonstrated that microRNA-1224 (miR-1224) is commonly downregulated and serves as a tumor suppressor in multiple malignancies.
Shikun Yang, Wei Jiang, Wenjie Yang, Chao Yang, Xinchen Yang, Keyan Chen, Yuanchang Hu, Gefenqiang Shen, Ling Lu, Feng Cheng, Feng Zhang, Jianhua Rao, Xuehao Wang   +12 more
doaj   +1 more source