Bacillus anthracis edema factor substrate specificity: evidence for new modes of action [PDF]
, 2012 Since the isolation of Bacillus anthracis exotoxins in the 1960s, the detrimental activity of edema factor (EF) was considered as adenylyl cyclase activity only.
Agrawal +94 more
core +2 more sources
The ever unfolding story of cAMP signaling in trypanosomatids: vive la difference! [PDF]
, 2015 Kinetoplastids are unicellular, eukaryotic, flagellated protozoans containing the eponymous kinetoplast. Within this order, the family of trypanosomatids are responsible for some of the most serious human diseases, including Chagas disease (Trypanosoma ...
De Koning, Harry P. +2 more
core +1 more source
MSK1 regulates transcriptional induction of Arc/Arg3.1 in response to neurotrophins [PDF]
, 2017 The immediate early gene activity-regulated cytoskeletal protein (Arc)/Arg3.1 and the neurotrophin brain-derived neurotrophic factor (BDNF) play important roles in synaptic plasticity and learning and memory in the mammalian brain.
Arthur, John +8 more
core +3 more sources
12-h clock regulation of genetic information flow by XBP1s [PDF]
, 2020 © The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Pan, Y., Ballance, H., Meng, H., Gonzalez, N., Kim, S., Abdurehman, L., York, B., Chen, X., Schnytzer,
Abdurehman, Leymaan +14 more
core +1 more source
Growth Suppression of Lung Cancer Cells by Targeting Cyclic AMP Response Element-Binding Protein [PDF]
Cancer Research, 2008 Abstract Genes regulated by cyclic AMP–response element-binding protein (CREB) have been reported to suppress apoptosis, induce cell proliferation, and mediate inflammation and tumor metastasis. However, it is not clear whether CREB is critically involved in lung carcinogenesis. We found that non–small cell lung cancer (NSCLC) cell lines
Sita Aggarwal +4 more
openaire +3 more sources
Interleukin 2 transcription factors as molecular targets of cAMP inhibition: delayed inhibition kinetics and combinatorial transcription roles [PDF]
, 1994 Elevation of cAMP can cause gene-specific inhibition of interleukin 2 (IL-2) expression. To investigate the mechanism of this effect, we have combined electrophoretic mobility shift assays and in vivo genomic footprinting to assess both the availability ...
Chen, Dan, Rothenberg, Ellen V.
core +2 more sources
Impact of transient down-regulation of DREAM in human embryonic stem cell pluripotency: The role of DREAM in the maintenance of hESCs [PDF]
, 2016 Little is knownabout the functions of downstreamregulatory element antagonist modulator (DREAM) inembryonic stem cells (ESCs). However, DREAM interacts with cAMP response element-binding protein (CREB) in a Ca2+-dependent manner, preventing CREB ...
Aguilera, Yolanda +6 more
core +1 more source
Porcine oocyte maturation in vitro : role of cAMP and oocyte-secreted factors: a practical approach [PDF]
, 2016 Polyspermy or the penetration of more than one sperm cell remains a problem during porcine in vitro fertilization (IVF). After in vitro culture of porcine zygotes, only a low percentage of blastocysts develop and their quality is inferior to that of in ...
Appeltant, Ruth +4 more
core +2 more sources
STING-dependent recognition of cyclic di-AMP mediates type I interferon responses during Chlamydia trachomatis infection. [PDF]
, 2013 UnlabelledSTING (stimulator of interferon [IFN] genes) initiates type I IFN responses in mammalian cells through the detection of microbial nucleic acids. The membrane-bound obligate intracellular bacterium Chlamydia trachomatis induces a STING-dependent
Barker, Jeffrey R +6 more
core +2 more sources
Delineation of RAID1, the RACK1 interaction domain located within the unique N-terminal region of the cAMP-specific phosphodiesterase, PDE4D5 [PDF]
, 2002 Background The cyclic AMP specific phosphodiesterase, PDE4D5 interacts with the β-propeller protein RACK1 to form a signaling scaffold complex in cells.
Bolger, G.B. +5 more
core +3 more sources