Results 21 to 30 of about 29,900 (296)

The first two decades of CREB-memory research: data for philosophy of neuroscience

AIMS Neuroscience, 2021
I recount some landmark discoveries that initially confirmed the cyclic AMP response element-binding (CREB) protein-memory consolidation and allocation linkages. This work constitutes one of the successes of the field of Molecular and Cellular Cognition (
John Bickle
doaj   +1 more source

Primary cilia control oligodendrocyte precursor cell proliferation in white matter injury via Hedgehog-independent CREB signaling

Cell Reports, 2023
Summary: Remyelination after white matter injury (WMI) often fails in diseases such as multiple sclerosis because of improper recruitment and repopulation of oligodendrocyte precursor cells (OPCs) in lesions.
Kimberly K. Hoi, Wenlong Xia, Ming Ming Wei, Maria Jose Ulloa Navas, Jose-Manuel Garcia Verdugo, Maxence V. Nachury, Jeremy F. Reiter, Stephen P.J. Fancy   +7 more
doaj   +1 more source

Resveratrol inhibits LPS-induced MAPKs activation via activation of the phosphatidylinositol 3-kinase pathway in murine RAW 264.7 macrophage cells. [PDF]

PLoS ONE, 2012
BACKGROUND: Resveratrol is a natural polyphenolic compound that has cardioprotective, anticancer and anti-inflammatory properties. We investigated the capacity of resveratrol to protect RAW 264.7 cells from inflammatory insults and explored mechanisms ...
Yi Zong, Lin Sun, Bin Liu, Yi-Shu Deng, Dong Zhan, Yuan-Li Chen, Ying He, Jing Liu, Zong-Ji Zhang, Jun Sun, Di Lu   +10 more
doaj   +1 more source

Cyclic AMP Response Element-Binding Protein in the Vessel Wall [PDF]

Circulation, 2003
Atherosclerosis and postangioplasty restenosis are leading causes of death in the Western world. Recent advances in our understanding of vascular biology would suggest that targeting specific signals in the post–balloon injury vessel or in persons prone to development of atherosclerosis could decrease lesion formation and in the long term decrease ...
Jane E.B. Reusch, Dwight J. Klemm
openaire   +1 more source

Regulation of Cox-2 by Cyclic AMP Response Element Binding Protein in Prostate Cancer: Potential Role for Nexrutine

Neoplasia: An International Journal for Oncology Research, 2007
We recently showed that NexrutineR, a Phellodendron amurense bark extract, suppresses proliferation of prostate cancer cell lines and tumor development in the transgenic adenocarcinoma of mouse prostate (TRAMP) model.
Rita Ghosh, Gretchen E. Garcia, Katherine Crosby, Hiroyasu Inoue, Ian M. Thompson, Dean A. Troyer, Addanki P. Kumar   +6 more
doaj   +1 more source

TetR hybrid transcription factors report cell signaling and are inhibited by doxycycline

BioTechniques, 2005
We developed a bigenic reporter system composed of a hybrid transcription factor that combines the regulatory and activation domains of either Elk-1 or cyclic AMP-responsive element binding protein (CREB) with the DNA binding, dimerization, and ...
Michael B. Keeley, Johanna Busch, Rajesh Singh, Ted Abel   +3 more
doaj   +1 more source

Cyclic-AMP response element binding protein (CREB) in the neutrophils of depressed patients. [PDF]

Psychiatry Res, 2011
Cyclic-AMP response element binding (CREB) protein regulates the expression of many genes involved in the pathophysiology of depression. Increased CREB levels were found in the brain of antidepressant-treated rats and decreased protein and mRNA expression of CREB was reported in the postmortem brain of depressed suicide victims.
Ren X, Dwivedi Y, Mondal AC, Pandey GN.
europepmc   +4 more sources

CREB Regulates AChE-R-Induced Proliferation of Human Glioblastoma Cells

Neoplasia: An International Journal for Oncology Research, 2004
The cyclic adenosine monophosphate (AMP) response element-binding protein, CREB, often modulates stress responses. Here, we report that CREB suppresses the glioblastoma proliferative effect of the stress-induced acetylcholinesterase variant, AChE-R.
Chava Perry, Ella H. Sklan, Hermona Soreq   +2 more
doaj   +1 more source

A Novel Small-Molecule Inhibitor Targeting CREB-CBP Complex Possesses Anti-Cancer Effects along with Cell Cycle Regulation, Autophagy Suppression and Endoplasmic Reticulum Stress. [PDF]

PLoS ONE, 2015
Lung adenocarcinoma, the most common subtype of lung cancer, is the leading cause of cancer death worldwide. Despite attempts for the treatment of lung cancer which have been accumulating, promising new therapies are still needed.
Jong Woo Lee, Hee Sun Park, Sin-Aye Park, Seung-Hee Ryu, Wuyi Meng, Juliane M Jürgensmeier, Jonathan M Kurie, Waun Ki Hong, Julie L Boyer, Roy S Herbst, Ja Seok Koo   +10 more
doaj   +1 more source

The Role of the CREB Protein Family Members and the Related Transcription Factors in Radioresistance Mechanisms

Life, 2021
In the framework of space flight, the risk of radiation carcinogenesis is considered a “red” risk due to the high likelihood of occurrence as well as the high potential impact on the quality of life in terms of disease-free survival after space missions.
Gianmarco Stati, Francesca Passaretta, Florelle Gindraux, Lucia Centurione, Roberta Di Pietro   +4 more
doaj   +1 more source