Results 51 to 60 of about 29,900 (296)

The Rapid and Long-Lasting Antidepressant Effects of Iridoid Fraction in Gardenia Jasminoides J.Ellis Are Dependent on Activating PKA-CREB Signaling Pathway

Frontiers in Pharmacology, 2022
Lag periods of therapeutic efficacy cause poor compliance of patients, which has made solutions for rapid antidepressants the most urgent need in the depression study field at present.
Li Ren, Hailou Zhang, Weiwei Tao, Yin Chen, Zhilu Zou, XiaoYan Guo, Qinqin Shen, Quansheng Feng, Jingqing Hu   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Molecular Determinants of the Spacing Effect

Neural Plasticity, 2012
Long-term memory formation is sensitive to the pattern of training sessions. Training distributed over time (spaced training) is superior at generating long-term memories than training presented with little or no rest interval (massed training).
Faisal Naqib, Wayne S. Sossin, Carole A. Farah   +2 more
doaj   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Growth Suppression of Lung Cancer Cells by Targeting Cyclic AMP Response Element-Binding Protein [PDF]

Cancer Research, 2008
Abstract Genes regulated by cyclic AMP–response element-binding protein (CREB) have been reported to suppress apoptosis, induce cell proliferation, and mediate inflammation and tumor metastasis. However, it is not clear whether CREB is critically involved in lung carcinogenesis. We found that non–small cell lung cancer (NSCLC) cell lines
Sita, Aggarwal, Seung-Wook, Kim, Seung-Hee, Ryu, Wen-Cheng, Chung, Ja Seok, Koo   +4 more
openaire   +2 more sources

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Sleep is enhanced in aged male mice that overexpress calcium/calmodulin-dependent protein kinase IV

Frontiers in Neuroscience
The dysregulation of sleep–wake patterns that occurs during aging is well documented and coincides with changes in intracellular signaling pathways that regulate sleep, such as the calcium/calmodulin-dependent protein kinase (CaMKII)/cyclic-AMP response ...
Sierra P. Feeney, Erin Threlfall, James M. Bilboa, Christopher C. Angelakos, Mathieu E. Wimmer, Satoshi Kida, Ted Abel, Ted Abel, Ted Abel, Jennifer C. Tudor, Jennifer C. Tudor   +10 more
doaj   +1 more source

Exogenous NAD⁺ Stimulates MUC2 Expression in LS 174T Goblet Cells via the PLC-Delta/PTGES/PKC-Delta/ERK/CREB Signaling Pathway

Biomolecules, 2020
Background: MUC2, a major component of the mucus layer in the intestine, is associated with antimicrobial activity and gut immune system function. Currently, mucin is mainly known for its critical function in defense against toxic molecules and pathogens.
Seongho Ma, Jiah Yeom, Young-Hee Lim
doaj   +1 more source

Systematical analysis reveals a strong cancer relevance of CREB1-regulated genes

Cancer Cell International, 2021
The transcription factor cyclic-AMP response element-binding protein 1 (CREB1) responds to cAMP level and controls the expression of target genes, which regulates nutrition partitioning.
Tianyu Zheng, Jinrong Huang, Xi Xiang, Siyuan Li, Jiaying Yu, Kunli Qu, Zhe Xu, Peng Han, Zhanying Dong, Yang Liu, Fengping Xu, Huanming Yang, Marja Jäättelä, Yonglun Luo, Bin Liu   +14 more
doaj   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source