A Prostacyclin Analog Prevents Radiocontrast Nephropathy via Phosphorylation of Cyclic AMP Response Element Binding Protein [PDF]
The American Journal of Pathology, 2005 We reported previously that radiocontrast medium induces caspase-dependent apoptosis and that cAMP analogs inhibit cell injury in cultured renal tubular cells. In the present study, cellular mechanisms underlying the protective effects of cAMP were determined.
Takahisa, Yano +8 more
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DNA Replication Stress-induced Phosphorylation of Cyclic AMP Response Element-binding Protein Mediated by ATM [PDF]
Journal of Biological Chemistry, 2006 The DNA damage-response regulators ATM (ataxia-telangiectasia-mutated) and ATR (ATM-Rad3-related) are structurally and functionally related protein kinases that exhibit nearly identical substrate specificities in vitro. Current paradigms hold that the relative contributions of ATM and ATR to nuclear substrate phosphorylation are dictated by the type of
Gerald E, Dodson, Randal S, Tibbetts
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Atractylenolide Ⅰ mitigates the inflammatory response in a rat model of dextransulfate sodium-induced chronic colitis [PDF]
Jichu yixue yu linchuangObjective To investigate the effect of Atractylenolide Ⅰ(AtraⅠ) on chronic colitis rats by regulation of cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA)/ cAMP response binding protein (CREB) pathway.
MOU Zhongyan, LIU Zhimin, ZHU Shuguang
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FEBS Letters, 2005 To maintain homeostasis, cells often respond to stressful extra‐cellular stimuli by new gene expression. Serum/glucocorticoid‐induced kinase (SGK) is an immediate early gene whose expression is induced by a variety of extra‐cellular stimuli. Here, we examine the possibility that SGK can directly phosphorylate the transcription factor cyclic AMP ...
David, Samuel, Kalb, Robert G.
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环境与职业医学BackgroundCyclic AMP response element binding protein (CREB) and miR-132-3p have been proved to be related to many neurodegenerative diseases. Our research group previously has demostrated that the neurotoxicity of aluminum is relevant to abnormal ...
Wenjie XIAO +3 more
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Application of Degradation of Cyclic-AMP Response Element Binding Protein for the Potential Treatment of Cancer. [PDF]
ACS Med Chem Lett, 2022 Kargbo RB.
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Cell Transplantation, 2018 The human placenta is an important source of stem cells that can be easily collected without ethical concerns since it is usually discarded after childbirth.
Lucia Centurione +8 more
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Cyclic AMP response element-binding protein is required in excitatory neurons in the forebrain to sustain wakefulness. [PDF]
Sleep, 2021 Wimmer ME, Cui R, Blackwell JM, Abel T.
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Roles of constitutive and signal-dependent protein phosphatase 2A docking motifs in burst attenuation of the cyclic AMP response element-binding protein. [PDF]
J Biol Chem, 2021 Kim SH +4 more
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Upregulation of P21-Activated Kinase 1 (PAK1)/CREB Axis in Squamous Non-Small Cell Lung Carcinoma
Cellular Physiology and Biochemistry, 2018 Background/Aims: p21-activated Ser/Thr kinase 1 (PAK1) is essential for the genesis and development of many cancers. The purpose of this study was to investigate the role of the PAK1–cyclic AMP response element-binding (CREB) axis in non-small cell lung ...
Jae Heun Chung +13 more
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