Results 281 to 290 of about 1,721,329 (334)

Discovery of Cyclic Peptide Inhibitors Targeted on TNFα-TNFR1 from Computational Design and Bioactivity Verification. [PDF]

Molecules
Zhang J, Zhao H, Zhou Q, Yang X, Qi H, Zhao Y, Yang L.   +6 more
europepmc   +1 more source

<i>In vitro</i> potentiation of tetracyclines in <i>Pseudomonas aeruginosa</i> by RW01, a new cyclic peptide. [PDF]

Antimicrob Agents Chemother
Roson-Calero N, Gomis Font MA, Ruiz-Soriano A, Just-Baringo X, Pachón-Ibáñez ME, Salvador JP, Marco MP, Giralt E, Oliver A, Ballesté-Delpierre C, Vila J.   +10 more
europepmc   +1 more source

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Identification of Covalent Cyclic Peptide Inhibitors in mRNA Display.

Journal of the American Chemical Society, 2023
Peptides have historically been underutilized for covalent inhibitor discovery, despite their unique abilities to interact with protein surfaces and interfaces.
Sabrina E Iskandar, Lilly F. Chiou, T. Leisner, Devan J. Shell, Jacqueline L. Norris-Drouin, C. Vaziri, K. Pearce, A. Bowers   +7 more
semanticscholar   +1 more source

Cyclic peptides

International Journal of Peptide and Protein Research, 1986
In order to investigate the role of the L‐2‐hydroxy‐3‐methylbutanoic acid residue at position 2 of AM‐toxin I (cyclic tetradepsipeptide) on necrotic activity for apple leaves, two analogs, [L‐lactic acid2] AM‐toxin I and [L‐2‐hydroxy‐4‐methylpentanoic acid2] AM‐toxin I, were synthesized by the conventional method for peptide synthesis.
HISAKAZU MIHARA, KOICHI IKESUE, SANNAMU LEE, HARUHIKO AOYAGI, TETSUO KATO, TAMIO UENO, NOBUO IZUMIYA   +6 more
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Cyclic Peptide Screening Methods for Preclinical Drug Discovery.

Journal of Medicinal Chemistry, 2022
Cyclic peptides are among the most diverse architectures for current drug discovery efforts. Their size, stability, and ease of synthesis provide attractive scaffolds to engage and modulate some of the most challenging targets, including protein-protein ...
Xinting Li, Timothy W. Craven, Paul M. Levine   +2 more
semanticscholar   +1 more source

Cyclic Peptide Design

Methods in Molecular Biology, 2019
Gilles Goetz
openaire   +2 more sources

Cyclic peptides.

International Journal of Peptide and Protein Research, 1985
cyclo(‐l‐Pro‐l‐Val‐l‐Pro‐l‐Val‐) (1L) and cyclo(‐l‐Pro‐d‐Val‐l‐Pro‐d‐Val‐) (1D) were synthesized by the conventional method for peptide synthesis. Conformations of 1L and 1D in solution were studied. Compound 1L has a cis‐trans‐cis‐trans backbone conformation with C2 symmetry in CDCl3.
TOSHIHISA UEDA, ISAO SADA, TETSUO KATO, NOBUO IZUMIYA   +3 more
openaire   +1 more source

CYCLIC PEPTIDES

International Journal of Peptide and Protein Research, 1980
Å number of cyclo (Δaminoacyl‐L‐aminoacyl) (Δaminoacyl =ΔAba, ΔVal, ΔLeu, ΔApp, ΔPhe and ΔTrp; L‐aminoacyl=L‐Ala, L‐Val, L‐Leu and L‐Lys (e‐Ac)) were synthesized by the condensation of cyclo (N‐acetyl‐Gly‐N‐acetyl‐L‐aminoacyl) with corresponding aldehyde or acetone and subsequent treatment with hydrazine. Each cyclo (Δaminoacyl‐L‐aminoacyl) except ones
TATSUHIKO KANMERA, SANNAMU LEE, HARUHIKO AOYAGI, NOBUO IZUMIYA   +3 more
openaire   +1 more source

Highly Potent, Selective, Biostable, and Cell-Permeable Cyclic d-Peptide for Dual-Targeting Therapy of Lung Cancer.

Journal of the American Chemical Society, 2022
The application of peptide drugs in cancer therapy is impeded by their poor biostability and weak cell permeability. Therefore, it is imperative to find biostable and cell-permeable peptide drugs for cancer treatment.
Yunjiang Zhou, Yunting Zou, Mei Yang, Shuang Mei, Xiaohao Liu, Huiyun Han, Chang-Dong Zhang, Miao-Miao Niu   +7 more
semanticscholar   +1 more source