Results 81 to 90 of about 864,219 (292)
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Peptide Coacervates Promote Cytosolic Delivery of STING Agonists for Cancer Immunotherapy
VaccinesBackground/Objectives: Cyclic dinucleotide stimulator of interferon genes (STING) agonists have emerged as potential agents in cancer immunotherapy, but their clinical applications are limited by relatively poor pharmacokinetic properties.
Wenlv Zheng +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Cyclic Peptides as Chemical Probes [PDF]
Cyclic peptides are an exciting class of compounds that are currently under-exploited as chemical probes. Recent advances in peptide chemistry, screening and sequencing technologies have enabled efficient generation and screening of natural-product like ...
Roper G, Kawamura A, Serrano L
core +2 more sources
Nature CommunicationsCyclic peptides exhibit remarkable stability, membrane permeability, and binding affinity, positioning them as promising therapeutics. However, their synthesis, particularly on-resin head-to-tail cyclization, remains challenging, with cyclization site ...
Yourong Pan +5 more
doaj +1 more source
Cyclic Peptides as Novel Therapeutic Microbicides: Engineering of Human Defensin Mimetics
Molecules, 2017 Cyclic peptides are receiving significant attention thanks to their antimicrobial activity and high serum stability, which is useful to develop and design novel antimicrobial agents.
Annarita Falanga +6 more
doaj +1 more source
Cyanobacterial Cyclic Peptides Containing cis-Pro Conformation [PDF]
More than 3,000 natural products have been identified from cyanobacteria. These natural products often displayed antiparasitic, anti-inflammatory, antimicrobial, and anticancer activities.
Haedar, Jabal Rahmat +3 more
core +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Synthesis of halogenated cyclic RGD-peptides
, 2022 Nachtigall B, Sewald N. Synthesis of halogenated cyclic RGD-peptides. In: Journal of Peptide Science. Vol 28.
Nachtigall, Beate +1 more
core
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source